* ActorAllusion: See the {{Crossover}} entry below.
** In the noted Crossover above, Michael mentions his old therapist was like a father to him and wonders how the new guy can just fill that spot. Enter [[Series/FamilyTies Michael Gross]].
** Meredith Baxter played Mike's mother.
** Fox's wife Tracy Pollan appeared in one episode as an old girlfriend, and then in a third season episode along with most of the other ex-girlfriends seen on the show at that point.
** For both Fox and Christopher Lloyd when the latter guest starred in "Film/BackToTheFuture IV: Judgment Day."
--->'''Mike:''' It's like stepping back in time.
--->'''Owen:''' The past is prologue, Michael. Men like us have to look ''[[ShoutOut to the future]]''!
--->'''Mike:''' ''({{Beat}})'' [[LampshadeHanging What the hell are you talking about?]]
** In "All the Mayor's Men," Mike quotes Johnny B. Goode - his signature song from ''Film/BackToTheFuture'' - as a Bible passage.
** In "The Great Debate," the Mayor goads a political opponent with clucking. When Mike is asked what the Mayor is up to, he responds knowingly that he's "doing the chicken." Marty [=McFly=] could be goaded into anything if he was called a chicken.
** When going to a hockey game, Stuart wears a jersey that Alan Ruck wore in ''Film/FerrisBuellersDayOff''.
** This carried over to Charlie Sheen, his father MartinSheen played his father on the show, and his then-girlfriend Denise Richards played one of his girlfriends on the show.
* TheDanza: Michael J. Fox as Michael Flaherty and Charlie Sheen as Charlie Crawford.
* HeyItsThatGuy: The Mayor is a real '''[[TheRockyHorrorPictureShow ASSHOLE!!]]'''
* TheOtherDarrin: Carter's pet Rags suddenly turns into a way more shaggy breed in a later season episode.
* WhatCouldHaveBeen: According to an [[http://www.avclub.com/articles/jon-cryer-on-charlie-sheens-work-ethic-and-correct,97494/3/ interview]] with Jon Cryer, at an ABC upfront presentation, he was asked if Charlie Sheen would be a good match to replace Michael J. Fox (this was right after Sheen's first period of sobering up). Cryer later learned that he himself was on the list of potential Fox replacements and had essentially talked himself out of a job. Of course, Cryer and Sheen would later [[TwoAndAHalfMen collaborate on a success of their own]].