- Creator Killer: The critical and financial failure of this film killed its animation studio.
- One-Book Author: The only directorial credit of Vanguard founder and producer John H. Williams.
- The Other Darrin:
- In the first film, Ham was voiced by Andy Samberg. In this one, Tom Kenny took over.
- Both Kilowatt and Zartog had their well-known actors (Kristin Chenoweth and Jeff Daniels) replaced with Laura Bailey and John DiMaggio.
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