Executive Meddling: Necessary example. Sazae used to end every episode by throwing a bean in the air and catching it in her mouth and swallowing it. When a child choked to death imitating her, this was changed; she now ends every episode by challenging the viewer to jan-ken-pon (rock/paper/scissors).
Hey, It's That Voice!: In the first three months of the show's broadcast, Katsuo was voiced by Nobuyo Ōyama, best known as the voice of Doraemon.
Keep Circulating the Tapes: Despite its long run, not one episode has ever been officially released on home video. This was due to a request creator Machiko Hasegawa made before she died. In fact, episodes broadcast before VCR's became the norm are extremely difficult to find because they've never been shown again since their original broadcast. This is partly the reason why the 40th anniversary special from 2009 was such a big event: they pulled out some old episodes from the 1970s and broadcast them again for the first time in decades.
Last of its Kind: This show has become famous among animation-buffs for being the very last traditionally-animated (hand-drawn on acetate cels and shot on film) cartoon in the world. Literally every other piece of "commercial" animation on the planet, if it's not already an All-CGI Cartoon, is at least composited and coloured digitallynote For reference, the last traditionally-animated anime film was Princess Mononoke; the last American TV cartoon to switch to digital production was Ed, Edd n Eddy in 2004; Happiness Is A Warm Blanket Charlie Brown was drawn by hand, uniquely for a 2011 film.
It's also the only still-running Japanese animated program that predates Anime as a distinct style, and is thus, not one.
The Other Darrin: Despite its long run this trope is averted with Sazae, Tara, Namihei, and Fune, whose voices are still performed by the same actors after more than 40 yearsnote One 2009 episode had someone else perform Fune, only because the voice actress was sick that day. However, there have been changes with voice actors for Katsuo (3 actors), Masuo (2), and Wakame (3).