Talking to Herself: Averted in NOLF 1, despite Kit Harris voicing both Cate Archer and Inge Wagner: they never actually talk to each other. Played straight in NOLF 2, where Jen Taylor voices both Cate Archer and Isako, who talk to each other several times in-between their fights.
The Other Darrin: Cate Archer's voice actress was switched between the first and second games; in the second game, she's voiced by the very well known Jen Taylor.
What Could Have Been - the entire reason the main character is female is that MGM/UA warned they would sue with the James Bond-like male secret agent Monolith had initially planned. The game was to be a straight spy thriller set in the 60's, with no humor involved.