The Manga's rendition of that scene, and then the ending...this troper was on the verge of tears, and they were NOT manly. Arc's farewell just cut into the heart, and poor Shiki's reaction very much mirrored his own.
Fringe Tearjerker but the Epilogue states that eventually Shiki's glasses will no longer be able to seal off his Mystic Eyes of Death Perception coupled with the strain that his power takes on his mind and body makes that only a few years to live at best. Shiki's okay with it, accepting that death comes to all things but its still pretty tragic, not to mention how his death would affect the heroines. As the first person to have a relationship with, Arcueid would take Shiki's loss pretty badly. Ciel lost her family and everyone she knew at her own hands no less and then loses her lover unable to do anything about it. Akiha, Hisui and Kohaku see Shiki die, revive, leave for eight years and return only to die a few years later.