The "victory" Median ending Revya contracts the Scarlet Iago and dies. As he/she dies, Gig is keeps telling him/her not to die, even saying that he could never replace Revya. He actually expresses concern over Revya as a person rather than just the fact that he's also going to die, which makes both of them dying and the souls ending up in Drazil's hands all the worse.
Shauna's death. If you didn't feel for her, your heart is made of stone.
Tear Jerker: Gestahl's last words to Reyva before his Heroic Sacrifice. Both the words, and the way he says them.
Gestahl: If I can grant my power to my child...then I have no regrets. I look forward to the new world you will create...the world you will lead. Hehe...hahaha!