Please don't list this on a work's page as a trope. Examples can go on the work's YMMV tab.
Tear Jerker: Breath of Fire IV
Nina's sister/Cray's betrothed, Princess Elina. Thanks to many nasty experiments, she's been turned into a god-like monster. It's not perfect though, and she's in extreme pain. You start a quest to find the only weapon that can injure gods, and Cray has to mercy kill her. Combined with the Mad Scientist pulling a Karma Houdini and you've got tears and anger. It's even worse when you realize this (probably) is a prequel, where the Mad Scientist perfected his work, and Big Bad IS a god-like monster.
It causes quite the Player Punch for people who have sisters in real life that they love dearly. Nina's narration of "I knew that I would never see my sister again" nearly broke this Troper.
There is also Fou-Lu's companions, who all die in one shape or another to help him escape from The Empire. The boar who bludgeons itself against a rock blocking a secret passage was pretty moving. But the farm girl who tended to Fou-Lu when he collapsed in her village and blocked the door and stalled for time when soldiers investigated her home to give Fou-Lu time to escape was really bad. Then they captured and sacrificed her to powerup a nuke they droppped on him. Aww man.
Ershin's last stand against the forces of the Empire. Yes, my tin-can friend...that was an appropriate time to laugh.
And the massacre of the Chek inhabitants, especially in the manga adaptation.
As above, finding out what happened to Elina and her fate.
Ershin's last stand against the forces of the Empire, which is Up to Eleven. Yes, my tin-can friend...that was an appropriate time to laugh.
The massacre of the Chek inhabitants was bad enough in the game, but in the manga adaption, some of the apprentices have warmed up to Ryu a lot and he grows fond of them. Their deaths trigger Ryu's Heroic BSOD and his breakdown before, during and afterwards is just tragic.