Quagmire's personality changes when he adopts a pet cat, which irks Peter. Meanwhile, after Brian gets arrested for having a bag of weed in his car (during Peter's botched attempt at ditching Quagmire's dead cat in the woods), he starts a campaign to have marijuana legalized.
"Episode 420" contains examples of (YMMV goes here):
- Arson, Murder, and Jaywalking: Brian says that with pot legalized, crime is down, productivity is up (which, according to DVD commentary, they couldn't say as the censors did not want marijuana to be glamorized), and ratings for Doctor Who are through the roof.
- Jerkass: Peter, who not only kills Quagmire's cat, but calmly takes Quagmire's reward money, admits he killed the cat, and closes the door on him.
- Selective Enforcement: The cops don't mind Peter with a bloody trashbag or a note saying "This is where we'll hide the body", but go nuts when they catch Brian with a small amount of pot.
- Shoot the Shaggy Dog
- Stoners Are Funny: As if the title's name wasn't enough.
- Take That: Carter and Peter make an anti-cannabis video showing Adolf Hitler as a pot smoker, but are then sued by Fox News for using their copyrighted image of Hitler.
- At one point Peter is too stoned to properly setup his own cutaway, and thus it ends up simply being a Long List of celebrities he hates. Chris Martin gets mentioned four times. Other celebrities mentioned on the list include: Carlos Mencia, Amy Winehouse, Paul Tsongas, Andy Samberg, Justin Timberlake, Eve Plumb, David Arquette, that forehead guy on The Office (Rainn Wilson), and Kate Beckinsale. According to DVD commentary, the celebrities on that list were picked at random and the writers have nothing against them, though some of the celebrities on that list are considered annoying and/or overrated enough for viewers in real life to hate them.
- To The Tune Of: "A Bag O' Weed" is sung to the tune of "Me Ol' Bamboo" from Chitty Chitty Bang Bang.