The part where the plane crash survivor goes home to beat his wife is slightly different between the DVD and the TV version. On TV, the wife is only slapped four times and looks clean-cut. On DVD, the wife looks roughed up and is slapped eight times.
The scene of Quagmire taking a job as Joe's home nurse was cut on the TV version because the FOX censors didn't like the poop jokes and Joe asking Quagmire if he'll help him commit suicide.
The still of Peter getting out of Paris Hilton's car with no underwear on (similar to Britney Spears) has his penis mercifully blurred out on the TV version (the DVD version doesn't have it blurred at all).
After Quagmire nails the flight attendant, he says on the DVD version: "Please exercise caution when standing up, as the contents of your vagina may have shifted during coitus." The TV version replaces "vagina" with "panties" (except the [adult swim] version)
The cutaway of Peter hosting The Lawrence Welk Show and shouting, "Holy shit, we're a-fucking smokin' now!" was cut for TV (while it would be easy to just bleep out "fuck" and "shit," as it's been done before, the reason the scene was cut was because of time reasons).
Hugh Hefner's pep talk to Quagmire: Hefner's line, "You know, I have a 13-inch penis" was changed on TV to "You know, I have a 13-inch member."
Call-Back: Brian tries to stop Stewie from drinking a cup of Peter's spit, but relents after remembering Stewie's No-Holds-Barred Beatdown on him from "Patriot Games".
Engineered Heroics: Peter's plan to get help Quagmire get his pilot's licence back involved drugging the flight creww of a plane, then having Quagmire step up to the controls and landing safely.
Imagine Spot: When Peter sees fuel being pumped into the plane, he has one of these where he believes that filling his pickup truck with plane fuel can make it fly.
Peter: Oh, no! Both the pilots are unconscious, and we're in a nosedive. If only there was someone on board who could save us. (No one responds) Peter: I said if only there was someone on board who could save us. Joe: Uh, Peter, I don't see Quagmire.
The fake commercial bumper at the end of the second act parodies the title sequence for Will & Grace.
The Hugh Hefner pep talk ends with "Notre Dame Victory March", which was also used during a similar scene in Airplane!. Music from that film is also used in the climax when Quagmire helps the plane land.
Then ending credits have Quagmire leaping and running through a hilly meadow of wildflowers a la Laura Ingalls.