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Anime and Manga
- In Haruhi Suzumiya, Kyon is the only non-superpowered member of the S.O.S. Brigade and many of the events they get caught up in tend to be over his head. As such, he often has to rely on Yuki's Techno Babble explanations, or Koizumi whenever he can't understand Yuki, to get a handle on things. Mikuru also chips in, as much as regulation will allow, since most of what she knows is "classified".
- Zenkichi from Medaka Box. While the people around him are certainly quirky, their abilities can't really be denied. Akune and Kikaijima are both scholarship students and specials, Medaka herself is talented at everything as an abnormal. Not to mention the Class 13, who are all incredibly talented in one area (though at a price). He is able to keep up with them with his abnormal amount of determination.
- In the Syfy show Eureka, Sheriff Carter often has to deal with the weirdness caused by the geniuses living in the town. The sheriff himself is a former U.S marshal.
- In Knight Rider, Michael Knight is friends with an educated British man, a Wrench Wench and an artificially intelligent car.
- This also occurs in the 2008 Knight Rider series, where the main character is surrounded by an AI expert, a woman who can speak six languages, a computer whiz and a Deadpan Snarker Ford Mustang.
- Sherlock: John, definitely. Wife's an assassin, best friend's a detective, and....well, yeah. He doubles as an Only Sane Man due to the fact that Sherlock's weirdness gets him into trouble and the like.
- The whole concept behind Head of the Class.
- Penny in The Big Bang Theory qualifies, being the only non-science geek in the group. That's pretty much the entire basis for her character, really.
- Also Howard, to a lesser extent. Sure, he has an MSc in Engineering, but that's still poor compared to Sheldon, Leonard, Raj, Amy, and Bernadette (ie. the entire remaining main cast) who all have PhD's in their fields.
- James Vega from Mass Effect 3. James is a self-admitted grunt on a team of scientific experts, technical geniuses, proven leaders and tacticians, and galactic saviors in general. James is also the only member of the team with no experience fighting Reapers.
- Makoto Naegi of Dangan Ronpa. An average Joe by his own admission, sheer luck gets him into Hope's Peak, where everybody else is the "Ultimate" in their chosen field.
- In Girl Genius, Moloch von Zinzer is surrounded by incredibly intelligent "sparks" who can dream up wonders of science before breakfast. However, when an experiment goes horribly awry, he's the only one to think of pulling the plug instead of panicking and shouting, "Nothing can stop it now!!!"
- In the first regular episode of The Simpsons, "Bart the Genius", Bart is mistaken for a genius after he cheats on a test and is enrolled in a school for prodigies.
- Go to any Mensa event in real life.
- Visiting the campus of a university or college can feel this way.
- Attending graduate school, at least in the sciences.