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Anime and Manga
- Nick Szalinski from Honey, I Shrunk the Kids
- Who is almost a carbon copy of his father, Wayne.
- Georgette in Amélie
- Daniel Jackson from the original Stargate movie. His allergies act up while traveling. Daniel's allergies play as a plot point sometimes in the spinoff series.
- Cameron from Ferris Bueller's Day Off
- There's one in National Lampoon's Van Wilder: Party Liaison; He just goes by the name of "Sick Boy" most of the time.
- Matt Farrell in Live Free or Die Hard. He spends most of the movie complaining about his asthma and blood sugar levels to John McClane but later becomes a Badass Bookworm.
- Woody Allen in practically everything he's been in.
- Joel Glicker from Addams Family Values.
- Among the four geeky leads in Fanboys, Windows is this.
Live Action TV
- Felix from The Odd Couple, especially the TV series which Flanderized his allergies.
- All of the Dorfmans from iCarly, also Jeremy. Freddie's mom treats him as though he is; this has gotten more and more ridiculous as his actor has gotten bigger and her character has gotten Flanderized.
- Lisa Zemo, who started off with braces, Nerd Glasses, and a perpetually stuffy nose. Subverted, however, because a season or two later she comes back looking less nerdy and on a new allergy medication. One episode has her temporarily revert to this, as she had allergies again and had to wear hypoallergenic clothing and glasses. This time without the curly hair and braces, though.
- The Big Bang Theory:
- Howard Wolowitz. He is asthmatic, allergic to peanuts, almonds, and walnuts, prone to canker sores and pink eye, succumbs to seasickness, has an incredibly high genetic risk of heart illness, and has transient idiopathic arrhythmia.
- Leonard Hofstadter, on top of having Nerd Glasses (which he is Blind Without 'Em) and asthma, is also lactose intolerant and has a deviated septum.
- Sheldon Cooper is usually healthy due to his highly regimented lifestyle, but succumbs very easily to illness (and becomes even more insufferable than usual when he does). Any deviation from his dietary routine results in serious intestinal distress.
- In one episode, Penny lampshades this trope when she asks Amy if there was any part of her body that was working properly.
- Cyrus from Andi Mack complains of low blood sugar, needs an inhaler in order to participate in physical activity, and becomes nauseous to the point of vomiting from motion sickness... riding a merry-go-round.
- The eponymous character in The Nerd is like this.
- William Barfée in The 25th Annual Putnam County Spelling Bee. Among other things, it's mentioned that a severe allergic reaction forced him out of the previous year's bee. He also has a "rare mucus membrane disorder" that produces chronic nasal congestion, and is sensitive about his personal space (among many other problems of socialization).
- The eponymous character in the several versions old Yiddish play The Two Kuni-Lemls is like this—limps, thick glasses, easily confused. Has a long speech about his health problems, including "I get indigestion when I walk." (The first version was a satire of Hasidism. He's an "ancestor" of the Jerry Lewis character.)
- Bentley from Sly Cooper, at least until he takes a level in badass in the sequels.
- Adorkable Communication Specialist Samantha Traynor from Mass Effect 3: "I'm allergic to dust. And cats. And public speaking. And I take a proton pump inhibitor for my stomach. And an inhaler for asthma." She also takes what Shepard informs her is a placebo for headaches.
- Lester Crest, the geeky Mission Control from Grand Theft Auto V. Justified since he actually has a wasting disease, and needs a cane to walk short distances.
- Carl from The Adventures of Jimmy Neutron
- Macie from As Told by Ginger
- Melman from Madagascar
- In Ruby Gloom Misery's cousin Malady (an occasional guest character) will always treat the phrase "How are you?" as a cue for an epic description of her ailments, usually finishing with something like "...it's a scrape. I'll be fine."
- Kyle Brovlofski's cousin Kyle in South Park
- Chuckie and his dad from Rugrats and All Grown Up!.
- Tino's cousin in The Weekenders is a subversion: when they were younger his health problems were so demanding that he slept with a humidifier and dehumidifier on for each nostril, and Tino dreads hanging out with him because of it. Once he finally lets his cousin get a word in edgewise, though, it turns out that he's now both healthy and cool.
- Dr. Mendel Craven from Godzilla: The Series. He's got allergies to everything.
- Milhouse from The Simpsons
- Arnold from The Magic School Bus, though his claims of illness/allergies could be a desperate attempt to avoid being taken on the (frequently bizarre and sometimes very dangerous) field trips that Ms. Frizzle seems to be so fond of.
- Filburt from Rocko's Modern Life who becomes physically ill even from the most mundane of tasks. "I'm nauseous. I'm nauseous. I'm nauseous. I'm nauseous..."
- In a creepy example, Cousin Arnie from Hey Arnold!. He's pale and has postnasal drip/sinus problems, and he's also a creepy sociopath with some kind of Ambiguous Disorder.
- Also, Brainy.
- Harold of Total Drama Island.
- Gordy Rinehart from Angela Anaconda.
- Subverted by Gretchen from Recess. She has the nasal voice, but otherwise doesn't have any known illnesses.
- Spongebob Squarepants is occasionally implied to be this. He's certainly pretty geeky to begin with (wears a button-down shirt tucked into his pants and a tie, has dorky interests, etc.) When he gets too worked-up about something, he'll start wheezing loudly. Mr Krabs also implied in one episode that Spongebob takes allergy medication. In the first Christmas episode, he's so shocked to see Santa Claus that he basically has an extremely happy, excited asthma attack and then faints.