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- The Xavier Institute, full stop. In case you thought “Hope you survive the experience” was hyperbole, the school has a pretty low survival rate. Special bonus points go to the class of New X-Men: Academy X, who began dying or being depowered en masse and randomly, without finishing the ongoing and set up storylines. Most school alums have died or gone through something extremely traumatic in their days at school at least once.
- The absurdly dangerous Jackson High in Gotham which Tim Drake infiltrates during the highly Anvilicious Batman story The Seduction of the Gun. Evidently well over 95% of the students there carry guns, every student Tim talks to there has been shot, and even though the school has metal detectors at the doors they're only turned on for a brief period on Wednesday mornings. For some reason. Tim's there for about two days and witnesses two murders.
- In the 1976 Exploitation Film Massacre at Central High, the student body is tormented by a trio of bullies. After new student David refuses to fall in line and intervenes in their Attempted Rape of two female students, they cripple him by kicking the jack from under the car he's working on, crushing his leg. This sends David on a Roaring Rampage of Revenge in which he kills the bullies in increasingly sadistic and gruesome ways. His revenge, however, does not stop once the bullies are dead and he begins to murder fellow bullying victims. Despite the absurdly high number of students that die under suspicious circumstances, the school is never shut down. No adults are even seen on screen until the final scene where the police show up to arrest the wrong suspects following David's Karmic Death.
- Buffy the Vampire Slayer: At Sunnydale High, student death is an accepted fact of life. It's not uncommon for any gathering place for teenagers to be over run by murderous bad guys. The principal insists it's thugs hopped up on PCP. During graduation, this trend is lampshaded with Buffy's senior class celebrating having the lowest mortality rate in Sunnydale High history.
- In Class (2016), Coal Hill Academy (which has a decades-long previous history in the Doctor Who franchise) has an unusually high death rate. The school and its students and staff are routinely attacked because of its Weirdness Magnet status which attracts Big Bads from across space and time. The first episode, "For Tonight We Might Die", focused on the disappearance and death of Kevin Williams. Another student commented on his disappearance saying:
"Everyone knows students at this school disappear. They all just pretend it isn't happening."
- In a slightly older version of the trope, Scream Queens (2015) features the ladies of Kappa Kappa Tau who are being systematically and grotesquely murdered by the serial killer, The Red Devil. While these deaths are concerning to the general student body and the police investigate, the weekly multiple murders aren't seen as sufficient reason to shutter the sorority (which has threatened litigation if day-to-day function is hampered in any way) or to suspend classes at the university for student safety. Nearly the entire sorority is murdered or accused of murder over the course of the first season, but it is treated like a bothersome in-house issue.
- Smallville: During Clark's teenaged years at Smallville High, one student a week would be revealed as a kryptofreak. They would usually kill one or two other students before Clark was able to figure out what was going on and stop them. In the first few episodes, the student body would be shown mourning the victims, but by season 2, dead classmates didn't even register as a blip on their collective radar.
- In the Supernatural episode "After School Special", no one seems particularly alarmed that the students suddenly start maiming and killing each other, with the assaults being treated like aggressive bullying. Authorities are not called in and Sam and Dean only show up because Sam reads about the attacks and remembers having attended the school as a kid. Since the cops were never called, Sam and Dean have to infiltrate as a custodian and a substitute gym teacher.
- Todd and the Book of Pure Evil: The town of Crowley Heights was founded by Satanist seeking a place to worship the Dark Lord in peace. As a result, Crowley High is a Weirdness Magnet as would be expected in a town founded by a satanic cult. The students routinely die brutally and ironically as part of the backlash of a wish they made using the book. Everyone knows the risk of casting a wish, but seem to think they will be the exception. The adults know what's happening but are either useless or evil.
- Dangan Ronpa. A group of students are invited by mysterious letter to attend Hope's Peak Academy. Once there, the invited group is forced to participate in a "death game" orchestrated by an animatronic bear. In order to win, the designated murderer must get away with murdering another student. All the other participants are working to uncover the true murderer. Death is the punishment for failure. If the murderer escapes detection, they will be the lone survivor. If the group unmasks the murderer, they will be released and the murderer executed. Despite the rules indicating that there has been at least one survivor per group, word has not spread to shut the school down and warn people against accepting the invites.
- Yandere Simulator: The method the player character uses to win the affections of their love interest, Senpai can create this type of school. The objective is to eliminate ten romantic rivals. Methods can be as benign as matchmaking your rival with another boy, more devious such as framing them for cheating on a test and getting them expelled, or completely vicious such as driving them to suicide or murdering them outright. If students start disappearing and bodies turn up as clear evidence of a murderous serial killer, the school's "atmosphere" level drops, making students apprehensive, frightened, and extremely vigilant. While the more paranoid atmosphere increases the game difficulty, multiple student deaths does not result in an automatic game over.
- Shut Up Cartoons series Oishi High School Battle, has Oishi Kawaii, a demon slayer from outerspace attending an Earth high school. However all of the demonic threats she fights have followed her over. As a result, student and staff deaths are pretty much a daily occurence, to the point where the school principal gets annoyed rather than horrified when notified of casualties.
- In Detentionaire, A. Nigma High appears to be an ordinary school at first glance, but as the series progresses it's anything but normal. For one the school is run by a cyborg principal who's a former army general and Drill Sergeant Nasty, constantly hunting bad students. There are psycho cleaners in hazmat suits, that are actually robotic drones that work for him. Then there's the unveiling of the conspiracy involving the school, where a select few shady individuals plan to take control on a global scale. Needless to say life endangerment is to be expected at this high school.
- In a younger version of the trope, The Simpsons Halloween Special Treehouse Of Horror V features "Nightmare Cafeteria", where the staff of Springfield Elementary decides to get rid of trouble makers by sending them to detention, where they are then killed and turned into next week's cafeteria menu. When Bart and Lisa tell their mother, Marge, what's happening, she refuses to help.
Bart and Lisa: Mom! Mom! You've gotta help! They're cooking kids in the school cafeteria.
Marge: Listen, kids. You're eight and ten years old now. I can't fight all your battle for you.
Bart and Lisa: But Mom...
Marge: No buts. You march right back to that school, look them straight in the eye and say "Please, don't eat me."
- Strange Hill High is a Weirdness Magnet and all sorts of monster and baddies have shown up to harass and terrorize the students. The main cast find themselves having to constantly foil the Monster of the Week while trying to stay alive.