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- The mooks in Until Death Do Us Part have explosives in their molars that they themselves can activate and that can be activated from afar. Soon enough Mamoru just cuts their jaws out.
- In Hellsing, Jan Valentine falls victim to one of these: a chip implanted in his head sets him on fire (one of the few surefire ways to kill a vampire) when his mission fails and he is captured. He knew it was going to happen too, so he took the moments leading up to it to troll his captors before dying.
- The Testament of Sister New Devil: The Master-Servant pact has an automated self-destruct option if the servant breaks a fundamental law. Like ratting out their conspirator master.
- Watchmen has a lowtech version of this, where Veidt pretends to be stopping a would-be assassin he hired himself from taking a Cyanide Pill, but actually had the pill himself, and shoves it down the other's throat.
- Members of the Suicide Squad each have explosives inside their bodies to detonate if they either (A) get captured, (B) fail their mission, or even (C) defy Amanda Waller.
- In Judge Dredd Mega City One Blitzers are hitmen with implanted explosives wired to detonate with the stress of capture.
- In Battlefield Earth, the sinister cabal of psychiatrists that rules the Psychlo race has implanted mind-control devices in their subjects' skulls, both to modify behavior and protect the all-important secret of teleportation. If an alien asks a Psychlo about teleportation or even mathematics, males are conditioned to go into a suicidal killing spree, while females go catatonic.
- In the Vorkosigan Saga, Imperial Security agents are doctored so that they will have a fatal allergic reaction when given the universe's Truth Serum, which ironically was intended to prevent torture, but obviously, most people who know anything couldn't be given it. The protagonist was too politically important to be doctored in this way, but because of his odd medical history, he has an unusual reaction to fastpenta (becoming a Talkative Loon), and is able to exploit this to beat one interrogation he's subjected to in the series. His clone brother Mark, who has an undamaged metabolism, does have the standard allergy to fastpenta and would die if he received it.
- This usually isn't a suicide mechanism though. It is standard policy for professionals to first test for a fastpenta induced allergy before using the drug. Thus it's unlikely that anyone important enough to have an induced allergy will be subjected to fastpenta without testing for it (don't want to accidentally kill a captive before you get information out of him). In practice this usually means the important operatives get to enjoy the old fashioned interrogation methods.
- In The Stars My Destination, the crew of the Vorga were implanted with a mechanism that would stop their hearts if they started to give information explaining why they passed by the wreck of the Nomad and the protagonist, Gully Foyle. When Foyle starts torturing the first of the crew members, he dies the moment he starts divulging information.
- After the second time this happens, Foyle gets annoyed. Using the illegal Bullet Time reflexes he paid for, he knocks out his third target, cuts out his heart and connects his circulatory system to an artificial blood pump within twenty seconds. Then he starts questioning him.
- In The Eyre Affair, when an associate of Acheron Hades started to tell the authorities what he knew, he spontaneously combusted.
- In the Onyx Court book Midnight Never Come, Invidiana has put a spell on Tiresias that will kill him if he tells what he knows about her. He decides it's worth the price.
- There's a fairly complicated version of this in the X-Wing Series novels by Stackpole. There's a drug called skirtopanol that is used in interrogating prisoners, since it lowers their defenses and makes them more sensitive to pain. But if someone's been taking lotiramine, the chemicals react, sometimes fatally. An Imperial gave lotiramine to someone he'd used, telling the man that it would protect him from a plague that was going around. When the local villain caught up with the Imperial, he told him that the man had gone into convulsions and died after being dosed with skirtopanol. The Imperial was surprised. He'd have had to have been taking four times the recommended dosage to go into convulsions.
- Actors in The Acts of Caine are conditioned so that they cannot (on Overworld) admit they are Actors, speak Earth languages, etc. Approaching the topic can give them fits. They will die before they can say it.
- This only holds for the first book. This backfires when the natives of Overworld realise that the Aktir (as they call the Actors) cannot say the word, so between the first and second books the Actors have their conditioning removed.
- In the Tortall Universe, a death spell can be used for this purpose. It doesn't save the victim from torture/Truth Serum interrogation, but it kills him if he tries to give up accurate information. Aly comments to a captured spy that "if someone put three death spells on me, I'd wonder whether they trusted me at all".
- Happens to one of the Grey Men in The Stainless Steel Rat's Revenge.
- Oleg Divov's Brothers in Reason starts with an unknown cabal kidnapping random (or so we think at first) people in Britain and trying to use a mind-reading machine on them, only for them to have a fatal heart attack just when the machine starts receiving data. They try a different approach with the wife of an influential politician, who is caught in bed with one of the protagonists. Instead of using the machine, the cabal members show her the photos of her affair and then start asking questions. Just as they're getting to the interesting parts, she also croaks. It turns out they were all members of a sister secret organization that the other protagonist works for, all members of which have mentally-implanted "kill switches" that are activated if unauthorized access is detected. It fails, however, when an extremely-powerful psychic uses his abilities to disable the kill switch in one of the operatives, allowing the mind-reader to work.
- An occasional plot device in Perry Rhodan. Usually employed by villains, one pretty grim example actually repeatedly used by the protagonists during the Hetos occupation of the Milky Way Galaxy (though with no instance of it triggering ever shown) was an acid capsule implanted in the brain of members of La Résistance on missions where they might fall into enemy hands, designed to dissolve and release its contents under torture or upon death; justified by their enemies' technology potentially still allowing them to retrieve information from dead brains as long as those were still reasonably intact.
- The Laundry Files has this as a side effect of trying to defy a security geas. "The Concrete Jungle" features an interrogation running up against a tightly-wounded geas that ends up cooking the subject's brain.
- Declare. Elana's handler uses one to try and kill her when she announces she's defecting to the French. Fortunately she was praying when the hypnotic "kill command" was implanted, and this somehow disrupted it.
- The Mesan Alignment in the Honor Harrington books use these on their lower ranking security officers, not only failing to tell them that they've put the implants in, but going so far as to have the implants kill in lots of different apparent ways so there aren't any statistical anomalies when Operation Houdini results in all of the non-expendable members of the Alignment having been extracted from Mesa and the Alignment gets to clearing up after themselves.
- Wormtail's metal hand in the Harry Potter books turns out to be this, ultimately killing its owner as punishment for hesitating to kill Harry.
- In Starship Troopers navigators who know the location of Sanctuary, the Navy's secret base/emergency backup homeworld, are hypnotically conditioned to suicide if captured.
- In Children of Dune,some people are implanted with a "heart-stopper" that will activate if they say the word "Jacurutu" (a place where people who are relevant to a certain plot) live.
Live Action Television
- The Priors in Stargate SG-1 are genetically programmed to burst into flame if they ever lose faith in their gods, The Ori. Though, Priors are so fanatically devout that this is hardly ever an issue, it's more common for them to trigger it intentionally.
- The brainwashed za'tarc assassins are programmed to commit suicide if their mission fails or if someone tries to mess with their brainwashing.
- A possible example occurs in UFO, though it could also be a fatal reaction to the truth serum due to the alien's different biology.
- An episode of Agents of S.H.I.E.L.D. dealt with a master thief who was being manipulated by an unknown party who had given her an artificial eye that functioned both as a camera and an explosive to be detonated in the event of her being compromised or disobeying an order. Her handler turns out to be under the same control and is killed this way when SHIELD catches up to him.
- Mentioned in the Mass Effect games in regards to Cerberus lackeys taken in for questioning...whereupon their heads explode. Mordin actually makes a joke about neural implants being more effective than explosives lodged in the teeth, as the latter can just be yanked out in case of defection.
- This is the fate of Vinceborg In Barkley, Shut Up and Jam: Gaiden.
- In Age of Empires II you can activate one by researching Heresy, which causes your units to die if they're converted by enemy monks instead of actually going over to the other side.
- A particularly horrifying example early on in Deus Ex: Human Revolution has a hacker who's being used as a remote-controlled puppet and forced to shoot himself in the head when Adam catches him.
Gunther: I..am not... a mach- *BOOM*
- Also done in the original Deus Ex, as a possible way of dealing with the cyborg Gunther Hermann. If you make the correct choice earlier in the game, you'll be given Hermann's killcode, which can be used when you meet him again in Paris. The phrase "Laputan Machine" activates Hermann's killswitch, causing him to explode.
- Black Hats in the Deadlands: Hell on Earth RPG have microchips implanted in their skulls that explode if they commit treason against their leader in any way.
- Explosive brain implants are a not-uncommon method for maintaining loyalty in Paranoia, notably employed (without disclosure) by the Shmegegi in Clones in Space.
- Dungeons & Dragons:
- Occurs in the adventure T1-4 Temple of Elemental Evil:
- Module DA1 Adventures in Blackmoor. All of the Iron Duke's agents in the Comeback Inn (as well as the Warden in the Prison Out Of Time) have a special Geas placed on them. If anyone uses torture or magic to try to force them to tell about the plan to kidnap King Uther, the Geas will kill them.
- Module OA5 Mad Monkey vs. the Dragon Claw. If the PCs capture any Dragon Claw monks while in the nation of T'u Lung and try to interrogate them in any way, the monks will burst into flames rather than reveal any of the secrets of their master. This effect is created by the demon Lung Jua (AKA the Dragon Claw) himself.
- In Schlock Mercenary Para Ventura's handlers in UNS Internal Affairs implanted a remote bomb in one of her cervical vertebrae. She seems rather disturbed after Petey removes it and informs her of its presence - and of the fact that her handlers just tried to trigger it.
- Gorilla Grodd remotely shuts down Metallo after he is captured in in Justice League Unlimited, but it isn't made clear whether this kills him or simply leaves him out of commission until someone can figure out how to fix him.
- In Totally Spies!, one Big Bad turned out to be an android who was only following the programming of the scientist who created him, who was also evil. He seemed to be the scientist until the very end, when he had a Robotic Reveal and explained everything, including that he was programmed to self-destruct if he ever revealed he wasn't human. Which he promptly did.