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- In Batman Eternal, Jim Gordon shoots and kills one of Professor Pyg's henchmen who he sees pointing a gun at him. However, Gordon's shots cause a train wreck in which people die. When no gun is found on the henchman's body, Gordon is sent to prison. It is later discovered that Gordon was framed by the Big Bad using Mind Control technology on him to cause him to see a gun when the henchman was unarmed.
- Nonlethal variation in one Rantanplan story: A cavalry officer has left his grandson Douglas in the care of the prison's warden, but he ran off with the circus along with Rantanplan. In order to keep the colonel from investigating, the warden forged letters from Douglas that claimed he's still in the prison. When both the circus and the colonel end up in the prison at the same time, the colonel demands to know about the letters he wrote, which of course Douglas knows nothing about. The warden quickly sweeps the fake letters off his desk where they're eaten by Rantanplan in the few seconds the colonel has his back turned. Having a bit of a breakdown, the colonel leaves.
- In Con Air, Poe is attacked outside a bar by a drunk with a knife and kills him. One of the drunk's friends grabs the knife before the police show up. This results in Poe being sent to the Super Max which starts the plot.
- The plot of Blue Steel is set off by the main villain stealing the gun of a robber the protagonist shoots, getting her suspended since there's no evidence he was armed.
- Variation in The Shawshank Redemption. Andy had a gun and was planning on killing his wife and her lover, but decided against it and threw the gun into a river. Then someone else murdered his wife and her lover, and since they can't find his gun they can't test to see if the bullets match or not.
D.A.: You claim you threw your gun into the Royal River before the murders took place. That's rather convenient.
Andy: It's the truth.
D.A.: You recall Lt. Mincher's testimony? He and his men dragged that river for three days and nary a gun was found. So no comparison can be made between your gun and the bullets taken from the bloodstained corpses of the victims. That's also rather convenient, isn't it, Mr. Dufresne?
Andy: Since I am innocent of this crime, sir, I find it decidedly inconvenient the gun was never found.
- In After the Thin Man, the murderer throws away the gun of someone he wants to frame. (As with the example above from The Shawshank Redemption, testing the gun would prove the suspect's innocence.)
- Inverted in Blade: Trinity, where Blade is tricked into killing a familiar instead of a vampire, so that the body doesn't disintegrate in the sunlight.
- In Fallen, the cop Hobbes is hunting a demonic serial killer, and gets provoked into shooting the demon's latest possessee in broad daylight. He knows no one will believe him if he tries to claim demonic possession was involved—but he can claim self-defense, since the man was pointing a gun at him, right? Nope, it turns out the gun was loaded with blanks, and the demon just possesses a bystander and testifies that Hobbes shot the man with no provocation.
- Sherlock Holmes: In "The Problem of Thor Bridge", a woman commits suicide using an elaborate method that disposes of the weapon, having already planted evidence that will frame the woman she considered a rival.
- In one of the Artemis Fowl books where Commander Root has a belt full of explosives locked on him and supposedly the only way to disarm it is to shoot a tiny corner of the attached screen displaying the villain's face. Holly Short shoots the screen to save Root, but the villain was lying and it explodes anyway. To the security cameras surrounding them, the belt and screen were invisible, so it looks like she shot the commander to death.
- Frontier Circus: In "Quick Shuffle", Ben catches a crooked dealer cheating him in a poker game. The dealer pulls a derringer and Ben shoots him. Another gambler kicks the derringer under a cupboard to get Ben arrested so he can use a doctored IOU to claim ownership of the circus.
- CSI Crime Scene Investigation:
- In the episode "Who Shot Sherlock", it's set up to make it look like the victim did this by attaching a gun to a piece of surgical tubing. It turns out the killer did this to make it look like a suicide set up to look like a murder. In the same episode, Sanders mentions that the families of suicides will often hide the gun to avoid the stigma.
- One of the many fallouts in the two-parter "A Bullet Runs Through" comes from the cops apparently shooting an unarmed suspect; it turns out that the cop turned around and saw him with a gun just as he was moving to throw it, meaning it was thrown on a roof as he was shot.
- One episode of Hill Street Blues has a rookie police officer shoot an armed suspect in an alley. When his veteran partner asks where the suspect's gun is, the rookie can't locate it. Not wanting his young partner to get railroaded by Internal Affairs, the senior officer produces a second firearm, puts the suspect's fingerprints on it, then announces that he "found" the perp's weapon. Later the suspect's actual weapon is found and both officers are put under investigation under suspicion of planting false evidence.
- In the Person of Interest episode "Zero Day", the Dirty Cop organization "HR" tries to assassinate Detective Carter, but Carter proves quicker on the trigger than the shooter. HR member Detective Terney improvises, pocketing the shooter's gun to make it look like Carter shot an unarmed man and getting her demoted by the premiere of the next season.
- A heroic example in the Stargate SG-1 episode "Covenant". Faced with an aerospace billionaire who means to blow the whistle on the stargate program, the SGC has their Asgard friend Thor beam the evidence right out of his office building so he can't prove anything he said, discrediting him.
- One episode of Dragnet has an unintentional example when an off-duty Joe Friday is shot at by a teenager attempting to rob a vending machine. Joe returns fire and fatally wounds the suspect, but then has trouble proving the other guy shot first when the crime scene investigators can't find the corresponding bullet. It hit a shelf at just the right angle for the shelf to cover the bullet hole. If one of the lab techs hadn't been an OCD case and wondered about an out-of-place "pencil mark" under the shelf, Friday would have gone down for murder.
Bill Gannon: Nothing's ever easy for you, is it, Joe?
- In one episode of Falling Skies, Anthony is put on duty guarding an Overlord that the 2nd Mass has taken prisoner. While watching the Overlord, he sees it pull out a small device that looks like a bomb, and opens fire, killing the Overlord. When the others arrive, the device has vanished, and they all assume that Anthony, who hasn't been in the best emotional shape recently, snapped and killed the Overlord in cold blood, and thus he is ordered to hand over his gun. This precipitates him making a Face–Heel Turn and joining Pope's revolt against the 2nd Mass.
- A larger scale version twice to The A-Team.
- The team were ordered by their commanding officer Morrison to rob the bank of Hanoi as part of a secret mission, but was then killed in an artillery strike and since the mission wasn't public knowledge the only people who knew the Team weren't just bank robbers were the Team themselves.
- The second was when it was revealed that Morrison had been a traitor and had sent them in to be ambushed and killed, which gave them a motive for Morrison's death. The witness who could prove that they weren't responsible ends up being killed by his criminal partners before the truth could come out.
- On The Closer, Sgt Gabriel returns fire on a fleeing murderer but the gun isn't found and it appears he's shot an unarmed man. Brenda realizes that the shooter, the man's partner in the original murder, had been standing right by him and disappeared in the darkness after Gabriel returned fire.
- One episode of Space Precinct has the cops accused of shooting down a criminal's car during a chase. The witnesses have been hypnotized into claiming it was unprovoked, and a robot who recorded everything is broken down.
- Hamilton: "I'm burning the memories, I'm burning the letters that might have redeemed you."
- At the beginning of Assassin's Creed II, the Auditore family is charged with treason and arrested. Ezio, the only man in the family to not get caught in the initial sweep, quickly acquires some documents that would exonerate them, but unfortunately, the court official he delivers them to is part of the conspiracy that framed his family, so the evidence disappears before the trial and Ezio's father and brothers are all hung.