- "Voice of Harold", which features Michael Stipe singing the liner notes to a Gospel album over the backing track of "7 Chinese Bros."
- Chances are you experienced the joy of hearing "It's the End of the World As We Know It (And I Feel Fine)" play on the radio (or in Rock Band due to a recent DLC pack) while your friends struggle to sing along with the lyrics that aren't the song title.
- As said in the Beam Me Up, Scotty! entry on the main page, "What's the Frequency, Kenneth?" got its title from an incident involving Dan Rather being attacked by someone, who kept shouting (some form of) the phrase as he was beating the veteran newsman. Now watch Dan Rather performing the song with them in 1995. You can't say the man has no sense of humor.
- Late in "The Sidewinder Sleeps Tonite" Michael Stipe can be heard audibly trying to hold back his laughter during the chorus, due to his perceived mispronunciation of the word "Seuss" (he thought he was saying "Dr. Zeus"). Made even funnier by the fact that it makes the already incomprehensible chorus even harder to understand.
- In the CD booklet for Part Lies, Part Heart, Part Truth, Part Garbage 1982–2011 as Stipe is discussing the music video for "Imitation of Life" he points out that holding a monkey or an orangutan in a music video was one of Peter Buck's life wishes.
- Michael Stipe's dancing in the music video for "Imitation of Life". Possibly in general, as well.
- Peter Buck's liner notes to Dead Letter Office are very funny (as is just about anything Peter Buck says), but the high point is his horrified and apologetic description of the circumstances behind the band's drunken, shambolic recording of "King of the Road".
Peter Buck: If there was any justice in the world, Roger Miller should be able to sue for what we did to this song.
- Also qualifying is the previous song, "Walter's Theme", recorded in the same take. The song was written as a faux-Kitschy Local Radio Commercial for the long-since-defunct Walter's BBQ in the band's hometown of Athens.
- The gleefully awful rhyme that opens "It Happened Today:" "This is not a parable. This is a terrible. This is a terrible... thing. Yes, I will rhyme that."
- Similarly, when Stipe flat-out admits he "can't even rhyme here with 'begin'" in the middle of "Begin the Begin".
- During their earlier days, the band loved abusing the Word of God trope, giving intentionally misleading and untrue answers to interview questions just to see if they'd get printed. Peter Buck is the cause of one such story, in which he "explained" that his father had been a Shakespearean actor, but had made his living playing the Ty-D-Bol Man, and ended up committing suicide. To his delight, the story got printed.
- Their appearance in The Simpsons episode "Homer the Moe". Homer gets them to play at his homemade bar by making them think they're playing to save the rainforest, until they found out the bar's a "hunting club".
Michael: Hunting club?! You lied to us!(Michael smashes a beer bottle and waves it menacingly before being held down by Mike and Peter)Mike: Michael, no!Peter: That's not the R.E.M. way.Michael: (sighs) You're right. Let's just recycle these shards and get out of here.