Being a game with lots of islands that each have its own cast of characters, Poptropica naturally has numerous characters.
- Main Charactersnote Player Character, Quippy, Amelia
- 2007 to 2008 Islandsnote Early Poptropica, Shark Tooth, Time Tangled, 24 Carrot, Super Power, Spy, Nabooti
- 2009 to 2010 Islandsnote Big Nate, Astro Knights, Counterfeit, Reality TV, Mythology, Skullduggery, Steamworks, Great Pumpkin
- 2011 to 2012 Islandsnote Cryptids, Wild West, Wimpy Wonderland, Red Dragon, Shrink Ray, Mystery Train, Game Show, Ghost Story, SOS Island, Vampire’s Curse, Twisted Thicket, Poptropolis, Wimpy Boardwalk, Lunar Colony, Super Villain, Charlie and the Chocolate Factory
- 2013 to 2014 Islandsnote Zomberry, Night Watch, Back Lot, Virus Hunter, Mocktropica, Monster Carnival, Survival, Mission Atlantis, Poptropi-CON, Arabian Nights
- 2015 to 2021 Islandsnote Galactic Hot Dogs, Mystery of the Map, Timmy Failure, Escape From Pelican Rock, Monkey Wrench, Snagglemast, RealityTV: Wild Safari, Fairy Tale, Goofball
- 2022 Islandsnote Secret of the Jade Scarab
- Worldsnote Crisis Caverns and Greek Sea Odyssey
- Poptropica (Comic Strip)
- Poptropica (Graphic Novel)
