The title character taking on Count Nefaria (a villain who's on the same power-level as freaking Thor) in a one-on-one fight and actually holding his own for a bit.
A bit? He was so angry (The Count had killed his friend Echo) that he managed to make the Count retreat. When Moon Knight woke up after, he found himself chained to a hospital bed.
The 2014 series.
First issue: Mr. Knight vs. the Slasher.
Mr. Knight: I stopped you two minutes ago. Look down.
Second issue: Surprisingly it isn't even Moon Knight, one of the sniper's intended victims found out what was going on, came out of the elevator as the sniper and Moon Knight were fighting and just shot him, ending the threat right there and then.
Third issue: Moon Knight punches ghosts! Nuff said!
Fifth issue: Mr. Knight beats his way through a building filled with criminals to rescue a kidnapping victim and when the last one tries to get away via the roof he orders his drone/glider to plaster him leaving the kidnapper a bloody mess and him in the position to give a Badass Boast.