Just managing to be a hunter in the World of Darkness. In a world where most people blatantly deny the supernatural and paranormal out of fear, or become part and parcel against their will or even willingly. Even if you do have some kind of special ability, you're going up against undead Machiavellians, beast-men, and wizards at the very least. You might have a gun, but you will have a cell. And that cell will stand with you, dammit. Yes, it's dark. Yes, you will die. You can still die lighting the darkness.
The Merrick Institute's Origin Story. After years being used as guinea pigs for painful dream experiments by a shadowy government organization, a group of child prodigies actually managed to communicate between themselves using code, overthrow their captors and take over the Institute, gaining their freedom in the process. Not only that, but they actually ended up starting their own conspiracy to fight monsters of their own will so they could protect people.