The fight with Col. Vanek in Project Origin. Watch his expression turning from angst to utter horror, while throwing out Cluster F-Bomb, then subsequently get his head blown off is quite satisfying, given how much of a nuisance he and his ATC death squad has been to you up till this point.
Hearing Replicas, who are supposed to be ruthless supersoldiers, yelling out in fear at the sight of you.
A little more understated, but the moment you figure out in the first game that you can do jumping and sliding kicks that are instant kills against normal soldiers, not to mention the effect of knocking them across the room. Doing it in Slow-Mo on the last enemy in a squad is extremely satisfying.
There's a bit of delay allowed for jumping kicks, so you can hit first with the normal melee attack from your gun, then press the jump button and finish with a jumping spin kick.
This troper once emptied his pistols into a Replica squad, slow-mo jump kicked the survivor, plucked his rifle out of mid-air with the 'hold X to swap' while effectively surfing his corpse across a table and opened fire on reinforcements before even hitting the ground.
The last hallucination in the first game. Seeing Alma screaming for her child, Harlan Wade's callous disregard for his own daughter, and the camera panning down to show her last name on the file, followed by reappearing in the darkness, and hearing Alma whisper in your ear, "I know who you are." That scene, and the terribly haunting, sympathetic music playing at the same time, is just chilling.
During the final APC sequence at Still Island, where Becket is holding off the Replica forces, this music plays. It's a perfect counterpoint, and it's awesome.
That moment when a firefight finally ends, and if the settings are turned appropriately high, there will be an eerie silence as a haze of gunsmoke, shredded paper and concrete dust slowly settles out of the air.
If you're skilled with stealth FPS games, you can sneak into a room full of enemies and, with a combination of slo-mo sharpshooting, grenades, mines and deception, take them all out without a scratch. Doing this repeatedly makes you really feel like you are the son of the most powerful thing on Earth.
About midway through the Extraction Point expansion, you're fighting your way through Replica-infested subway tunnels, and then Child Alma shows up... to help you, strolling right through an enemy squad, turning them all to Ludicrous Gibs simply through her mere presence. After spending the main game terrified of her, it's a great feeling to have her on your side for once.
The final section of Extraction Point has you on a rooftop, awaiting helicopter arrival. Paxton Fettel ominously remarks, "You should know better by now." Cue the action music as you engage in one final firefight with the best of the Replica forces. It's an epic final showdown to top off the expansion.