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[[caption-width-right:350:At least these two see [[IncrediblyLamePun eye to eye.]]]]

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[[caption-width-right:350:At least these two see [[IncrediblyLamePun [[{{Pun}} eye to eye.]]]]
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* Heterochromia becomes an important clue in one of the extremely difficult mysteries ''[[TheKindaichiCaseFiles Kindaichi]]'' is forced to unravel.

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* ''TheKindaichiCaseFiles'': Heterochromia becomes an important clue in one of the extremely difficult mysteries ''[[TheKindaichiCaseFiles Kindaichi]]'' the titular detective is forced to unravel.
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* In BlackDaggerBrotherhood, Quinn has one green, one blue eye; though described pretty often as beautiful, in a world where any 'imperfection' is treated as a shame on the family, he is neglected his entire life because of them and eventually disowned- leading to his practically paralytic lack of self worth and massive tendency towards overcompensation. Eventually they seem to have a point, as he [[sppoiler: starts having visions.]]

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* In BlackDaggerBrotherhood, ''Literature/BlackDaggerBrotherhood'', Quinn has one green, one blue eye; though described pretty often as beautiful, in a world where any 'imperfection' is treated as a shame on the family, he is neglected his entire life because of them and eventually disowned- leading to his practically paralytic lack of self worth and massive tendency towards overcompensation. Eventually they seem to have a point, as he [[sppoiler: starts having visions.]]
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* BigBad God of War Homura from ''{{Saiyuki}}'' has one [[SupernaturalGoldEyes golden]] eye, and one blue one, as a result of his [[HalfHumanHybrid father being a human]].

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* BigBad God of War Homura from ''{{Saiyuki}}'' ''Manga/{{Saiyuki}}'' has one [[SupernaturalGoldEyes golden]] eye, and one blue one, as a result of his [[HalfHumanHybrid father being a human]].
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* ''Anime/HeavyMetalLGaim'': [[BigBad Emperor Oldna Posseydal]]. Her right eye is yellow, and her left eye is blue.
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* The protagonist of ''ShutterIsland'' describes Andrew Laeddis, the madman who killed his wife, as having mismatched eyes. [[spoiler: Subverted in that the description is a fabrication dreamed up by the protagonist, who ''is'' Laeddis but is in complete denial of that fact.]]

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* The protagonist of ''ShutterIsland'' ''Film/ShutterIsland'' describes Andrew Laeddis, the madman who killed his wife, as having mismatched eyes. [[spoiler: Subverted in that the description is a fabrication dreamed up by the protagonist, who ''is'' Laeddis but is in complete denial of that fact.]]
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* Neko in ''Anime/ProjectK'' has her eyes green and blue in her human form, which makes her look far from normal.

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* Neko in ''Anime/ProjectK'' from ''Anime/{{K}}'' has her eyes a green right eye and blue left eye in her human form, which makes her look far from normal. She's not, of course, and is quickly identified as a [[RandomlyGifted Strain]], an individual with supernatural powers that were not given by a [[SuperEmpowering King]]. Her specialty is creating illusions and [[spoiler:modifying the memories of the people around her with her presence]].

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* The original ''Fighting Champions'' has Genzo's left eye blue in the portraits, but this is due to the low-res graphical ability of the ACS Madoka arcade board.
** Shogun has a red right eye.



* The Tsukino siblings from ''Rumble! @ The Campus'' have a green left eye and a blue right one.
** Kiyo, however, counters it by winking with her left eye the whole time.
* ''Raging Fist'': Ciel has a red left eye and a blue right eye.
** Ditto that with her bicolored hair.

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* The Tsukino siblings from ''Rumble! @ The Campus'' have a green left eye and a blue right one.
** Kiyo, however, counters it by winking with her left eye the whole time.
* ''Raging Fist'': Ciel
''Fight or Die'': Yuko Amano has a red left eye and a blue right eye.
eye. Though she has normal blue eyes in a flashback.
** Ditto Do note that with that her bicolored hair.body is in Lucifero's possession and that the red eye is that of Lucifero's. Yuko's blue eye is the normal one.

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* Farideh, heroine of ''Literature/BrimstoneAngels'' has one silver eye, one gold eye (the only visible difference from her twin sister Havilar, whose eyes are both gold). Now, Farideh is a tiefling (a humanoid with a distinctly demonic appearance, down to horns and a tail) and as such is more than used to [[FantasticRacism people thinking she's evil just because of what she looks like]], but for many strangers her MismatchedEyes seal the deal and put her fimrly into ObviouslyEvil territory, despite the fact that [[DarkIsNotEvil she's not]], and this has had a pretty noticeable impact on her personality.

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* Farideh, heroine of ''Literature/BrimstoneAngels'' has one silver eye, one gold eye (the only visible difference from her twin sister Havilar, whose eyes are both gold). Now, Farideh is a tiefling (a humanoid with a distinctly demonic appearance, down to horns and a tail) and as such is more than used to [[FantasticRacism people thinking she's evil just because of what she looks like]], but for many strangers her MismatchedEyes seal the deal and put her fimrly firmly into ObviouslyEvil territory, despite the fact that [[DarkIsNotEvil she's not]], and this has had a pretty noticeable impact on her personality. personality.
* 'Alex' in the ''Bill the Vampire'' series, has one brown eye and one green. It turns out he's [[spoiler:AlexanderTheGreat]].
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* Shiki from the ''SamuraiShodown'' series has naturally blue eyes, but one of them is red, indicating her mind being possessed by Yuga the Destroyer. The other stays as it is because she struggles to prevent her mind from being completely overtaken.
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* The hitman in ''Film/MulhollandDrive'' is having one blue and one brown eye in the first part of the movie. In the second part his pair of eyes are blue.

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Fixed Wotch filler comic link


* Anibelle from ''TheWotch'' has one red eye and one green eye. Easiest to see in [[http://www.thewotch.com/index.php?epDate=2007-01-24 this filler comic]] done by a guest artist, but can easily be seen [[http://www.thewotch.com/index.php?epDate=2008-08-12 normally,]] too.

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* Anibelle from ''TheWotch'' has one red eye and one green eye. Easiest to see in [[http://www.[[http://extras.thewotch.com/index.php?epDate=2007-01-24 com/?date=2007-01-24 this filler comic]] done by a guest artist, but can easily be seen [[http://www.thewotch.com/index.php?epDate=2008-08-12 normally,]] too.
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* ''LightNovel/HyakkaRyouranSamuraiGirls'':
** Gisen's [[EyePatchOfPower patched eye]] is red. She can also use some powerful spells with it.
** In the final episode of the first season [[spoiler:Jubei gets one eye coloured for each of her two personalities, signifying that both are in power. Asskicking ensues.]]
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* Farideh, heroine of ''Literature/BrimstoneAngels'' has one silver eye, one gold eye (the only visible difference from her twin sister Havilar, whose eyes are both gold). Now, Farideh is a tiefling (a humanoid with a distinctly demonic appearance, down to horns and a tail) and as such is more than used to [[FantasticRacism people thinking she's evil just because of what she looks like]], but for many strangers her MismatchedEyes seal the deal and put her fimrly into ObviouslyEvil territory, despite the fact that [[DarkIsNotEvil she's not]], and this has had a pretty noticeable impact on her personality.
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* The 1999 ITV miniseries adaptation of ''OliverTwist'' gave Edward "Monks" Leeford one brown eye and one blue eye. Funnily enough he was played by Marc Warren, who went on to play Jonathan Teatime -- another character with mismatched eyes -- in the film adaptation of Terry Pratchett's ''Discworld/{{Hogfather}}''.

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* The 1999 ITV miniseries adaptation of ''OliverTwist'' ''Literature/OliverTwist'' gave Edward "Monks" Leeford one brown eye and one blue eye. Funnily enough he was played by Marc Warren, who went on to play Jonathan Teatime -- another character with mismatched eyes -- in the film adaptation of Terry Pratchett's ''Discworld/{{Hogfather}}''.
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* In ''KatekyoHitmanReborn'' Rokudo Mukuro has a red right eye with kanji in it and a normal, blue left eye. His right eye changes the kanji to suit the number of which path's (six paths of hell) powers he is using at that moment.

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* In ''KatekyoHitmanReborn'' ''Manga/KatekyoHitmanReborn'' Rokudo Mukuro has a red right eye with kanji in it and a normal, blue left eye. His right eye changes the kanji to suit the number of which path's (six paths of hell) powers he is using at that moment.
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* Neko in ProjectK has her eyes green and blue in her human form, which makes her look far from normal.

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* Neko in ProjectK ''Anime/ProjectK'' has her eyes green and blue in her human form, which makes her look far from normal.



* Vincent Nightray in PandoraHearts was abandoned by his parents due to one of his eyes being red, a sign of him being a child of misfortune. His other eye is yellow.

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* Vincent Nightray in PandoraHearts ''PandoraHearts'' was abandoned by his parents due to one of his eyes being red, a sign of him being a child of misfortune. His other eye is yellow.

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* Neko in {{K}} has her eyes green and blue in her human form, which makes her look far from normal.

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* Neko in {{K}} ProjectK has her eyes green and blue in her human form, which makes her look far from normal.


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* Vincent Nightray in PandoraHearts was abandoned by his parents due to one of his eyes being red, a sign of him being a child of misfortune. His other eye is yellow.
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* Neko in {{K}} has her eyes green and blue in her human form, which makes her look far from normal.
* Ren Hakuryuu in ''Manga/MagiLabyrinthOfMagic'' has a realistic variation in which one of his blue eyes is much lighter than the other due to trauma.
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* Tyrion Lannister from ''ASongOfIceAndFire'' has one green eye and one black one. This may come from either heterochromia or partial aniridia, and are among several other congenital defects with which contribute to his nickname of "[[TheMagnificent the Imp]]". That aside, Tyrion sometimes uses his eyes to unsettle and intimidate people when it serves his purposes.

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* Tyrion Lannister from ''ASongOfIceAndFire'' ''Literature/ASongOfIceAndFire'' has one green eye and one black one. This may come from either heterochromia or partial aniridia, and are among several other congenital defects with which contribute to his nickname of "[[TheMagnificent the Imp]]". That aside, Tyrion sometimes uses his eyes to unsettle and intimidate people when it serves his purposes.



* ''StarWars'' ExpandedUniverse: Gaeriel Captison has mismatched eyes. They're constantly referred to in the book in which she's Luke's LoveInterest, possibly indicating that Luke finds this an attractive feature. As does villainess Ysanne Isard, main antagonist of the ''[[XWingSeries X-Wing]]'' books. The right is [[IcyBlueEyes blue]], and the left is {{red|EyesTakeWarning}}. They're often [[EvilEye symbolically attached]] to the cold efficiency (her nickname is Iceheart) and fiery anger she's known for.

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* ''StarWars'' ExpandedUniverse: In the Franchise/StarWarsExpandedUniverse, Gaeriel Captison has mismatched eyes. They're constantly referred to in the book in which she's Luke's LoveInterest, possibly indicating that Luke finds this an attractive feature. As does villainess Ysanne Isard, main antagonist of the ''[[XWingSeries X-Wing]]'' books. The right is [[IcyBlueEyes blue]], and the left is {{red|EyesTakeWarning}}. They're often [[EvilEye symbolically attached]] to the cold efficiency (her nickname is Iceheart) and fiery anger she's known for.



* In TheBlackDDaggerBrotherhood, Quinn has one green, one blue eye; though described pretty often as beautiful, in a world where any 'imperfection' is treated as a shame on the family, he is neglected his entire life because of them and eventually disowned- leading to his practically paralytic lack of self worth and massive tendency towards overcompensation. Eventually they seem to have a point, as he [[sppoiler: starts having visions.]]

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* In TheBlackDDaggerBrotherhood, BlackDaggerBrotherhood, Quinn has one green, one blue eye; though described pretty often as beautiful, in a world where any 'imperfection' is treated as a shame on the family, he is neglected his entire life because of them and eventually disowned- leading to his practically paralytic lack of self worth and massive tendency towards overcompensation. Eventually they seem to have a point, as he [[sppoiler: starts having visions.]]



* In Kristin Cashore's ''{{Graceling}}'', all "Gracelings" have this as a distinguishing characteristic. It becomes important to the plot when you find out that [[spoiler:one of the kings is missing an eye, and it later turns out that he is Graced with a very effective version of CharmPerson, as it can work even second- and third-hand, via rumors]].

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* In Kristin Cashore's ''{{Graceling}}'', ''Literature/{{Graceling}}'', all "Gracelings" have this as a distinguishing characteristic. It becomes important to the plot when you find out that [[spoiler:one of the kings is missing an eye, and it later turns out that he is Graced with a very effective version of CharmPerson, as it can work even second- and third-hand, via rumors]].



* One ''{{Goosebumps}}'' book has the main character's best friend be a girl with MismatchedEyes. This becomes a plot point when she mysteriously disappears and he starts seeing a dog with MismatchedEyes around the neighborhood.

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* One ''{{Goosebumps}}'' ''Literature/{{Goosebumps}}'' book has the main character's best friend be a girl with MismatchedEyes. This becomes a plot point when she mysteriously disappears and he starts seeing a dog with MismatchedEyes around the neighborhood.



* In the ''KeysToTheKingdom'' series, The Old One has one gold eye and one black one.

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* In the ''KeysToTheKingdom'' ''Literature/KeysToTheKingdom'' series, The Old One has one gold eye and one black one.



* In Skulduggery Pleasant (books 'dark days' and 'mortal coil') there's Davina Marr, who is discribed twice as having heterochromia, but the colours of her eyes are never specified. It's signficant to her role/character seeing as she does possess magic powers, although she is far from the only one in the series.

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* In Skulduggery Pleasant the Literature/SkulduggeryPleasant (books 'dark days' and 'mortal coil') there's Davina Marr, who is discribed twice as having heterochromia, but the colours of her eyes are never specified. It's signficant to her role/character seeing as she does possess magic powers, although she is far from the only one in the series.
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Removing Nightmare Fuel potholes. NF should be on YMMV only.


* Hnick from Dmitri Yemets's book series ''Methodius Buslaev'' has one blue eye and one black eye according to book 3. Romasjusik is also described as having one golden eye and one orange eye. Both cases aren't natural, since the latter has artificial body, while former's body [[NightmareFuel is stitched from at last two different corpses.]]

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* Hnick from Dmitri Yemets's book series ''Methodius Buslaev'' has one blue eye and one black eye according to book 3. Romasjusik is also described as having one golden eye and one orange eye. Both cases aren't natural, since the latter has artificial body, while former's body [[NightmareFuel is stitched from at last two different corpses.]]

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* Asuna from ''MahouSenseiNegima'' has heterochromia. The exact significance is unknown, but it's especially notable for its ''absence'' in adaptations that don't get into her BackStory. [[spoiler:Volume 26's cover has revealed that Arika Entheofushia -- Asuna's relative and Negi's mother -- has/had this as well]].

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* Asuna from ''MahouSenseiNegima'' has heterochromia. The exact significance is unknown, but it's especially notable for its ''absence'' in adaptations that don't get into her BackStory. [[spoiler:Volume
** Volume
26's cover has revealed that Arika Entheofushia -- [[spoiler:-- Asuna's relative and Negi's mother -- --]] has/had this as well]].well.

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** [[{{vocaloid}} Utatane Piko]] has one blue eye and one green eye.

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** [[{{vocaloid}} [[{{Vocaloid}} Utatane Piko]] has one blue eye and one green eye.



* Wrestling/{{WWE}} wrestler Wrestler/{{Kane}} has one light-blue eye and one brown eye, with the pupils being slightly different sizes (an effect achieved by the wrestler wearing non-matching contacts, like MarilynManson). Early in his run, it was implied that the blue eye was actually damaged by the fire which had "scarred" him and that the eye was actually a false eye. This was ignored as the years went on, and now the mismatched eyes aren't even commented on at all, but because it's such a well known feature of the character, it has remained despite no longer even seeming to matter in [[ContinuitySnarl the character's admittedly screwed up history.]]
* Similar to Kane, there was Glacier from WCW, though he had a martial-arts gimmick and dressed to look like [[MortalKombat Sub-Zero]]. He wore a blue contact lens over one eye; when his gimmick had been run thoroughly into the ground, he "sold" the contact lens along with his mask and "armor" he wore during his entrance, to another wrestler. The fact that he gleefully hawked off the garb that had BEEN his character for over three years was just one of the first instances which showed which direction the newly arrived VinceRusso was planning to take the company.

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* Wrestling/{{WWE}} wrestler Wrestler/{{Kane}} has one light-blue eye and one brown eye, with the pupils being slightly different sizes (an effect achieved by the wrestler wearing non-matching contacts, like MarilynManson).Music/MarilynManson). Early in his run, it was implied that the blue eye was actually damaged by the fire which had "scarred" him and that the eye was actually a false eye. This was ignored as the years went on, and now the mismatched eyes aren't even commented on at all, but because it's such a well known feature of the character, it has remained despite no longer even seeming to matter in [[ContinuitySnarl the character's admittedly screwed up history.]]
* Similar to Kane, there was Glacier from WCW, though he had a martial-arts gimmick and dressed to look like [[MortalKombat [[Franchise/MortalKombat Sub-Zero]]. He wore a blue contact lens over one eye; when his gimmick had been run thoroughly into the ground, he "sold" the contact lens along with his mask and "armor" he wore during his entrance, to another wrestler. The fact that he gleefully hawked off the garb that had BEEN his character for over three years was just one of the first instances which showed which direction the newly arrived VinceRusso was planning to take the company.



* Shelyn, the Goddess of love and beauty in ''{{Pathfinder}}'' sometimes appears with one blue eye and one silver eye.

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* Shelyn, the Goddess of love and beauty in ''{{Pathfinder}}'' ''TabletopGame/{{Pathfinder}}'' sometimes appears with one blue eye and one silver eye.



[[folder:Toys]]
* In the ''Franchise/MonsterHigh'' toys, [[Literature/{{Frankenstein}} Frankie Stein]] has one blue eye and one yellow eye.
[[/folder]]



* Marx from ''KirbySuperStar'' is frequently depicted in fan art as having one blue eye and one red eye, either matching or opposite the blue and red sides of his hat. However, in the official artwork and sprites, both of his eyes are {{purple|Eyes}}.

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* Marx from ''KirbySuperStar'' ''VideoGame/KirbySuperStar'' is frequently depicted in fan art as having one blue eye and one red eye, either matching or opposite the blue and red sides of his hat. However, in the official artwork and sprites, both of his eyes are {{purple|Eyes}}.



** Levi Tolar, on-again off-again [[TheDragon Dragon]], originally from ''VideoGame/SuperRobotWarsAlpha'', has one [[RedEyesTakeWarning red]] and one [[SupernaturalGoldEyes golden]] eye, to match her mecha Judecca. Her eye color changes fairly regularly though, depending on game and [[spoiler:whether her [[SuperPoweredEvilSide Levi personality]] or her Mai Kobayashi personality is dominant.]]

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** Levi Tolar, on-again off-again [[TheDragon Dragon]], originally from ''VideoGame/SuperRobotWarsAlpha'', has one [[RedEyesTakeWarning red]] and one [[SupernaturalGoldEyes golden]] eye, to match her mecha Judecca. Her eye color changes fairly regularly though, depending on game and [[spoiler:whether her [[SuperPoweredEvilSide [[SuperpoweredEvilSide Levi personality]] or her Mai Kobayashi personality is dominant.]]



* The GUN Commander from ''ShadowTheHedgehog'', during the game's events and during flashbacks.
* Ranulf in the 9th/10th ''FireEmblem'' games has one Blue and one Pink/Purple colored eye. Though this is, plotwise, insignificant, a bit of reading implied that this led to potential blindness in cats, which ''may'' explain why he got his [[TheWorfEffect ass handed to him by every significant bad guy]] (and one good guy) despite being implied to be one of the strongest among Cat laguz... i.e. he keeps losing because he can't ''see'' worth a damn.

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* The GUN Commander from ''ShadowTheHedgehog'', ''VideoGame/ShadowTheHedgehog'', during the game's events and during flashbacks.
* Ranulf in the 9th/10th ''FireEmblem'' ''Franchise/FireEmblem'' games has one Blue and one Pink/Purple colored eye. Though this is, plotwise, insignificant, a bit of reading implied that this led to potential blindness in cats, which ''may'' explain why he got his [[TheWorfEffect ass handed to him by every significant bad guy]] (and one good guy) despite being implied to be one of the strongest among Cat laguz... i.e. he keeps losing because he can't ''see'' worth a damn.



** Also from the ''FireEmblem'' games is Idoun one of the enemies in the 6th game, who has a red eye and a green eye. (It might actually be blue, but with sprites it's a bit difficult to tell.)

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** Also from the ''FireEmblem'' ''Franchise/FireEmblem'' games is Idoun one of the enemies in the 6th game, who has a red eye and a green eye. (It might actually be blue, but with sprites it's a bit difficult to tell.)



** ''VideoGame/{{Psychonauts}}'' is full of people with mismatched eyes. Bobby Zilch as another one, as well as Coach Oleander and [[FluffyTheTerrible Linda]].
* Honoka Kawai from ''OsuTatakaeOuendan 2'' has a green right eye and a gray left eye.

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** ''VideoGame/{{Psychonauts}}'' ''Psychonauts'' is full of people with mismatched eyes. Bobby Zilch as another one, as well as Coach Oleander and [[FluffyTheTerrible Linda]].
* Honoka Kawai from ''OsuTatakaeOuendan ''VideoGame/OsuTatakaeOuendan 2'' has a green right eye and a gray left eye.



* Yuber in ''SuikodenIII'' has one red eye and one silver one. He's also not human.
* Ragna the Bloodedge of ''BlazBlue'' has these to indicate that [[spoiler:he is half-{{Vampire}}. However, this only applies in one particular instance of the StableTimeLoop: in all others, including the one covered by the story, his changed eye, the red one, is linked to the function of his arm, the fake Azure Grimoire. When it stops working, so does his arm.]]

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* Yuber in ''SuikodenIII'' ''VideoGame/SuikodenIII'' has one red eye and one silver one. He's also not human.
* Ragna the Bloodedge of ''BlazBlue'' ''VideoGame/BlazBlue'' has these to indicate that [[spoiler:he is half-{{Vampire}}. However, this only applies in one particular instance of the StableTimeLoop: in all others, including the one covered by the story, his changed eye, the red one, is linked to the function of his arm, the fake Azure Grimoire. When it stops working, so does his arm.]]



* The Iris twins from ''RuneFactory Frontier'', just like Souseiseki and Suiseiseki, have opposite-color heterochromia.
* Lee, an early boss from ''SwordOfMana'', has one gold eye and one red one. It doesn't seem to be particularly indicative of anything, though.
* In the ''VideoGame/CallOfDuty: ModernWarfare'' series, the BigBad Vladimir Makarov has one green eye and one blue eye, though in ''3'', his models seem to lose the trait.

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* The Iris twins from ''RuneFactory ''VideoGame/RuneFactory Frontier'', just like Souseiseki and Suiseiseki, have opposite-color heterochromia.
* Lee, an early boss from ''SwordOfMana'', ''VideoGame/SwordOfMana'', has one gold eye and one red one. It doesn't seem to be particularly indicative of anything, though.
* In the ''VideoGame/CallOfDuty: ModernWarfare'' VideoGame/ModernWarfare'' series, the BigBad Vladimir Makarov has one green eye and one blue eye, though in ''3'', his models seem to lose the trait.



* [[EveryoneCallsHimBarkeep The Wizard]] in ''HarvestMoon: Animal Parade'' has one gold eye and one green eye.

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* [[EveryoneCallsHimBarkeep The Wizard]] in ''HarvestMoon: ''VideoGame/HarvestMoon: Animal Parade'' has one gold eye and one green eye.



* Sting Chameleon, from the ''MegaManX'' series, has an odd version of this. Being a robot, one of his eyes looks normal, but the other looks metallic and appears to have an irising lid. The irises, however, are the same color.

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* Sting Chameleon, from the ''MegaManX'' ''VideoGame/MegaManX'' series, has an odd version of this. Being a robot, one of his eyes looks normal, but the other looks metallic and appears to have an irising lid. The irises, however, are the same color.



* In ''DeadlyPremonition'', [[spoiler:Zach]] is eventually revealed to have different-colored eyes, his left eye having been damaged in a childhood trauma.
* In ''RagnarokOnline'', the pope of Arunafeltz [[spoiler:and her twin brother]] has opposite-color heterochromia. Apparently, this was one of the reasons she was chosen as pope. The other reasons was her hair and skin color.

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* In ''DeadlyPremonition'', ''VideoGame/DeadlyPremonition'', [[spoiler:Zach]] is eventually revealed to have different-colored eyes, his left eye having been damaged in a childhood trauma.
* In ''RagnarokOnline'', ''VideoGame/RagnarokOnline'', the pope of Arunafeltz [[spoiler:and her twin brother]] has opposite-color heterochromia. Apparently, this was one of the reasons she was chosen as pope. The other reasons was her hair and skin color.



* ''PuyoPuyo'' has Sig, who has one red eye and one blue eye.
* There's a few examples in ''VampireTheMasqueradeBloodlines''. The Voermen sisters have blue and green, Mister Ox has grey and amber, and the Malkavian and Nosferatu [=PCs=] have blue and brown.

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* ''PuyoPuyo'' ''VideoGame/PuyoPuyo'' has Sig, who has one red eye and one blue eye.
* There's a few examples in ''VampireTheMasqueradeBloodlines''.''VideoGame/VampireTheMasqueradeBloodlines''. The Voermen sisters have blue and green, Mister Ox has grey and amber, and the Malkavian and Nosferatu [=PCs=] have blue and brown.



* Ironhead from ''SwimIkachan'' has a right red eye and a blue left eye, although you couldn't tell the latter's colour in his [[TheCameo cameo appearance]] in ''VideoGame/CaveStory'', since it can only be seen when he's facing left.

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* Ironhead from ''SwimIkachan'' ''VideoGame/SwimIkachan'' has a right red eye and a blue left eye, although you couldn't tell the latter's colour in his [[TheCameo cameo appearance]] in ''VideoGame/CaveStory'', since it can only be seen when he's facing left.



* Ned from ''{{Doug}}'' has one [[BlackBeadEyes black bead eye]] and one round white eye with a black iris.
* Skrawl from {{Chalkzone}} has one blue eye and one red eye.

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* Ned from ''{{Doug}}'' ''WesternAnimation/{{Doug}}'' has one [[BlackBeadEyes black bead eye]] and one round white eye with a black iris.
* Skrawl from {{Chalkzone}} ''WesternAnimation/ChalkZone'' has one blue eye and one red eye.



* Emery from ''{{Chuggington}}'' has one blue eye and one green eye. Pretty weird, considering he's a train...

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* Emery from ''{{Chuggington}}'' ''WesternAnimation/{{Chuggington}}'' has one blue eye and one green eye. Pretty weird, considering he's a train...

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Achmed 'the Snake' from Elizabeth Haydons' Symphony of Ages has mismatched eyes because he is a crossbreed of 2 very different species. The color isn't given, but they are described as being different shapes. Being a freak wherever he goes forms a big part of Achmed's character.

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* Achmed 'the Snake' from Elizabeth Haydons' Symphony of Ages has mismatched eyes because he is a crossbreed of 2 very different species. The color isn't given, but they are described as being different shapes. Being a freak wherever he goes forms a big part of Achmed's character.



* Tyrion Lannister in ''ASongOfIceAndFire'' has, in addition to several other congenital defects, either heterochromia or partial aniridia, with one green eye and one black one.

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* Tyrion Lannister in from ''ASongOfIceAndFire'' has, in addition to several other congenital defects, has one green eye and one black one. This may come from either heterochromia or partial aniridia, and are among several other congenital defects with one green eye which contribute to his nickname of "[[TheMagnificent the Imp]]". That aside, Tyrion sometimes uses his eyes to unsettle and one black one.intimidate people when it serves his purposes.
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Achmed 'the Snake' from Elizabeth Haydons' Symphony of Ages has mismatched eyes because he is a crossbreed of 2 very different species. The color isn't given, but they are described as being different shapes. Being a freak wherever he goes forms a big part of Achmed's character.
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[[caption-width-right:350:At least these two see [[IncrediblyLamePun eye to eye.]]

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[[caption-width-right:350:At least these two see [[IncrediblyLamePun eye to eye.]]
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[[caption-width-right:350:At least these two see [[IncrediblyLamePun eye to eye.]]
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* [[KungFuPanda2 Su Wu]] has one gold eye and one light blue eye, giving her a rather creepy appearance.
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* [[KungFuPanda2 Su Wu]] has one gold eye and one light blue eye, giving her a rather creepy appearance.
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* Watanuki in ''Manga/XxxHOLiC'' loses his eyesight in one eye and eventually [[spoiler:eats/shares one of Doumeki's eyes to "fix" this, changing one of his eye colors. This is shown in the black and white manga by one of his pupils being incompletely inked.]] If you think this is coincidence that it resembles ''TsubasaReservoirChronicle'', Yuuko would like a word with you.

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* Watanuki in ''Manga/XxxHOLiC'' loses his eyesight in one eye and eventually [[spoiler:eats/shares one [[spoiler:comes to share half of Doumeki's eyes right eye to "fix" this, changing one of his eye colors. This is shown in the black and white manga by one of his pupils being incompletely inked.]] If you think this is coincidence that it resembles ''TsubasaReservoirChronicle'', Yuuko would like a word with you.

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