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1!Franchise/MarvelUniverse
2RoguesGalleryTransplant in this franchise.
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4[[quoteright:350:[[ComicBook/SpiderManDeadpool https://static.tvtropes.org/pmwiki/pub/images/smdp.jpg]]]]
5->''"Who she could be is a nightmare list I don't even want to think about...but probably should. Star is an obvious choice. Moonstone. Minn-Erva. Deathbird. Mystique. All contenders. Though Mystique seems too preoccupied these days to come after me. Deathbird too."''
6-->'''[[Characters/MarvelComicsCarolDanvers Carol Danvers/Captain Marvel]]''' [[LampshadeHanging acknowledging her past arch-foes]]; ''ComicBook/{{Captain Marvel|KellyThompson}}'' vol. 10, issue 32 (Mystique and Deathbird have both gone on to become ComicBook/XMen villains)
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11!!Comic Books
12* Wilson Fisk, [[Characters/MarvelComicsTheKingpin the Kingpin]], was introduced as a ComicBook/SpiderMan villain, and although very much still a part of Spidey's RoguesGallery, you'd be hard-pressed to say that the character is not best known for being a nemesis of ComicBook/{{Daredevil}}, taking the place of the Owl (who is a lot harder to take seriously) among his enemies. Since he is more of a BigBad for street-level superheroes in general, Kingpin unlike most examples on this list never completely lost his connection with Spider-Man, and across all media still opposes him on a semi-regular basis, but it's just that his beef with Daredevil is far more [[ItsPersonal personal.]] This transition is so well accepted that Creator/StanLee himself confessed that in retrospect, the Kingpin is much better suited as a Daredevil villain and that was the case legally when the film license rights to ''Daredevil'' were out of Marvel's hands with Kingpin officially part of that property.
13** The majority of Kingpin's appearances in Marvel Comics have been in ''Daredevil'' titles. He made a grand total of 19 appearances in Spider-Man titles before the start of Creator/FrankMiller's run, and it was only with Daredevil that Fisk became a BreakoutVillain. Fisk's later appearances in Spider-Man are often patterned on the characterization that Miller gave him in that story.
14** Referenced (but not used directly) in ''WesternAnimation/SpiderManTheAnimatedSeries''; Fisk is the BigBad for much of the show, but in the episode where Daredevil does appear, it's made very clear that for him, ItsPersonal, while for Spidey, it's more of your standard hero/villain thing. [[WordOfGod Greg Weisman]] says they wanted Kingpin to be part of ''WesternAnimation/TheSpectacularSpiderman'''s BigBadEnsemble, but couldn't because Creator/{{Sony}} only had the rights to ''Spider-Man'' characters and Marvel officially classifies him as a ''Daredevil'' villain now. (They wound up making Tombstone into an {{Expy}} of him, and left a few hints that he might be working for somebody else.)
15** On account of the fact that Spider-Man is more of an all-ages character than Daredevil and far more ubiquitous and popular, i.e. it's easier to greenlight a Spider-Man cartoon than a Daredevil one, Kingpin in multiple media still shows up as a regular part of Spider-Man's Rogues Gallery in diverse animated adaptations and video games. His two major live-action appearances have been in Daredevil properties and both of them target a PG-13 to R crowd. He is Spidey's archenemy in the continuity of the [[VideoGame/SpiderManPS4 Insomniac's Spider-Man game]] and BigBad of it's prequel novel (although he is just the WarmupBoss in the game proper, his defeat leading to an EvilPowerVacuum that starts the main conflict of the game), he's appeared as a Spider-Man BigBad in ''WesternAnimation/SpiderManIntoTheSpiderVerse'' (where he [[HeroKiller murders]] one version of Peter), and he's part of a BigBadEnsemble in the ''ComicBook/UltimateSpiderMan2000'' comics and ''WesternAnimation/SpiderManTheAnimatedSeries'', which still acknowledge him as being a more [[ItsPersonal personal]] foe of [[HeroOfAnotherStory Daredevil]], though he's mostly seen giving Spider-Man grief. In 616 comics, Kingpin still appears as a regular foe of Spider-Man but hasn't been the BigBad of a storyline since ''Back in Black'', which involved Spider-Man [[NoHoldsBarredBeatdown cutting loose]] and mocking Kingpin for having no powers and demonstrating how powerful Peter really is, making it hard for later writers to use him in the traditional way before. As such, Kingpin shows up more as TheManBehindTheMan and crime broker for other bad guys than a physical threat in his own right. However, perhaps due to his association with the more adult-oriented Daredevil, the Kingpin does ''not'' appear in the ''WesternAnimation/UltimateSpiderMan2012'' or ''WesternAnimation/MarvelsSpiderMan'' cartoons, being left out in favor of different crime lord rogues that were solely Spider-Man villains, most notably Hammerhead.
16** He ends up as the final BigBad in ''ComicBook/ThePunisherMAX'' (along with ComicBook/{{Bullseye|Marvel Comics}} and ComicBook/{{Elektra}}), a 'verse which has no superpowers.
17* Other Spidey villains have been known to torment Daredevil from time to time, and vice-versa; the guys practically live next door to each other, so there's a ton of overlap (the Beetle being certainly the most recurring after Kingpin). Inverted with Mysterio who seems to have not so much transferred to Daredevil's gallery as branched out, via ''ComicBook/GuardianDevil'', a story that saw Mysterio killed off for a time after trying to break Daredevil (copying what happened in ''ComicBook/BornAgain'', only this time it got Daredevil's love interest Karen Page killed), becoming an enemy of both of them. Then he ended up [[ComicBook/SpiderMen switching to Spider-Men]]. Electro was prominently considered part of both Spider-Man and Daredevil's galleries at the same time during their early years.[[note]]He actually didn't show up that often at the time, but when he did, he alternated between them.[[/note]] Case in point: The first ''Amazing Spider-Man'' annual had various supervillains Spidey had defeated before gang up, as the Sinister Six, in order to have their revenge on him. When ''Daredevil'' got an annual, too, we saw Electro forming the Emissaries of Evil [[RecycledScript consisting of villains who wanted revenge]] on DD. He later went on to fight a larger variety of heroes before ultimately becoming associated with Spider-Man again, though he is well known for being hired to cause a breakout at the Raft that formed the ComicBook/NewAvengers.
18* While primarily an enemy of Spider-Man, ComicBook/DoctorOctopus has had notable clashes with ComicBook/IronMan, a rival genius. He's also antagonized ComicBook/CaptainAmerica, ComicBook/TheIncredibleHulk and other New York based character like Daredevil and ComicBook/ThePunisher.
19* The various Green Goblins were notable for being solely Spider-Man villains, never antagonizing other New York-based heroes as Doc Ock or Electro would. Since ''ComicBook/SecretInvasion2008'', however, ComicBook/NormanOsborn has been transformed into an over-riding BigBad of the Franchise/MarvelUniverse, specifically clashing with the ComicBook/NewAvengers. After trying to take the Avengers again with another team of ComicBook/DarkAvengers and a H.A.M.M.E.R. made up of ComicBook/{{HYDRA}} and A.I.M. personnel, he has gone back to being a Spidey villain. [[spoiler:Firmly reestablished at the GrandFinale of ''ComicBook/SuperiorSpiderMan''.]] The run of Captain America by Ta-Nehisi Coates would then include him in the Power Elite that opposed Captain America.
20* Since his resurrection Kraven the Hunter and his daughter Ana have been seen fighting other superheroes on a daily basis, mostly related to Spider-Man like ComicBook/{{Venom}}, [[ComicBook/SpiderWoman Spider-Girl]] or ComicBook/ScarletSpider, but ComicBook/BlackPanther and [[ComicBook/TheIncredibleHulk the Hulk]] are also fair game. It helps Kraven seems to now live in the Savage Land, a place commonly visited by various superheroes.
21* In ComicBook/AnyaCorazon's time as Spider-Girl, most of her antagonists were minor Spider-Man villains, like the Ana Kravinoff, Screwball or Hobgoblin.
22* During Kaine's tenure as the ComicBook/ScarletSpider, he seems to have inherited the Jackal, the Lobo siblings, Shathra, Kraven and Ana Kravinoff from his 'brother', Spidey (though the Jackal is his creator and therefore a long standing part of his story), the Hand from Daredevil, Belladonna Boudreaux and the Assassins Guild from [[Characters/MarvelComicsGambit Gambit]], [[Characters/MarvelComicsCarnage Carnage]] from Spider-Man/Venom and evil MegaCorp Roxxon from Iron Man -- though for Roxxon, it's shared custody with Thor (and more recently the Hulk). Now, he's (reluctantly) one of the ComicBook/NewWarriors and as a result seems to have acquired the High Evolutionary and the Evolutionaries from the ComicBook/XMen.
23* Speaking of, the High Evolutionary originated in the pages of ''ComicBook/TheMightyThor'', but has since gone on to encounter the Avengers, the Fantastic Four, [[ComicBook/Warlock1967 Adam Warlock]], the Silver Surfer, the X-Men, the ComicBook/GuardiansOfTheGalaxy, the ComicBook/HeroesForHire, the ComicBook/UncannyAvengers and even the ComicBook/NewWarriors. What makes him somewhat unique is that he is [[HeelFaceRevolvingDoor often an ally rather than an enemy]], depending on who is writing at the time. He notably appeared as the main antagonist of the ''Evolutionary War'' CrisisCrossover during the 80s, where his machinations threatened pretty much the entire Marvel Universe (including an appearance in Marvel's ''Series/{{ALF}}'' comic, of all places, which later become semi-canon). He also played a role in the origins of ComicBook/ScarletWitch, ComicBook/{{Quicksilver}} and ComicBook/SpiderWoman.
24* The ComicBook/IronMan storyline ''ComicBook/ArmorWars'' has Tony go after a few non-Iron Man villains like the Beetle (originally an enemy of the Human Torch and later, Spider-Man) and the Gremlin (a Hulk villlain).
25** ComicBook/DoctorDoom is one of the villains Tony suspects might have used his stolen technology. Averted in this case as it's not true.
26** ZigZaggingTrope with Gremlin. Gremlin uses the name and the armor of the Titanium Man, an Iron Man foe who goes way back, but Gremlin himself is primarily a Hulk villain, first appearing in ''ComicBook/TheIncredibleHulk'' #163.
27** Stilt-Man, appearing in ''Iron Man'' #225, is a straighter example, starting out as a ComicBook/{{Daredevil}} villain (his first appearance in ''Daredevil'' #8), and having fought ComicBook/SpiderMan before this.
28* The Phoenix Force, while going back and forth through the HeelFaceRevolvingDoor at a rate of knots and often subject to BlueAndOrangeMorality, is usually near inextricably related to the X-Men and their associated books, such as ComicBook/{{Excalibur}} - and in the latter case, only because ComicBook/RachelSummers was on the roster. Recently, however, the entity first became a global threat in ''ComicBook/AvengersVsXMen'', then shuffled over to the ''Thor'' books under Jason Aaron's pen, making an important appearance in ''ComicBook/Thor2014'' and the King Thor sections of his ''Thor'' run, being revealed to have a complicated relationship with Asgard (having hooked up with both Odin and Thor in the past). While she simultaneously appeared in the ''ComicBook/JeanGrey'' book in the run up to ''ComicBook/PhoenixResurrection'', the culmination of that book had Jean firmly tell the entity to sod off and leave her alone, suggesting that she's out of the X-Men's orbit for the time being. The Phoenix Force returned in a big way for a storyline in ''ComicBook/TheAvengersJasonAaron'', which ended with former Avenger and recurring Daredevil ally Echo becoming the entity’s new host.
29* Given that [[Characters/MarvelComicsXMan Nate Grey a.k.a. X-Man]] dropped in out of [[ComicBook/AgeOfApocalypse alternate universe]] very early in his history, and wasn't really affiliated with anyone thanks to being a FishOutOfWater, a bit of a loner, and deeply paranoid about being manipulated (with good reason). As a result, he had very few villains of his own, at first - Dark Beast, Holocaust, and Sugar Man. And of the three of them, only Holocaust was really stupid enough to pick a fight with him. This plus power plus ChronicHeroSyndrome meant that he ran into everyone's villains at one point or another, including Exodus, the Marauders, the Abomination during his King-of-the-Sewer-People period, Onslaught, Mysterio, Electro, and Stryfe. Heck, he even tangled with Morbius briefly. Also [[HeelFaceRevolvingDoor Maddie Pryor]], [[{{Yandere}} when she wasn't helping him]]. The main one, though, was Apocalypse who represents everything Nate despises and is the root of his concept of evil.
30* Spidey inherited minor ComicBook/CaptainAmerica villain Vermin, J.M. [=DeMatteis=] basically pulling a Creator/ChrisClaremont - though it was a relatively smooth transition, as Spidey first encountered Vermin in a team-up with Cap.
31* Shriek was introduced as an opponent for ComicBook/CloakAndDagger, but after ''ComicBook/MaximumCarnage'' she is more known as a Spider-Man villain and girlfriend of one of his most famous antagonists, Carnage. Speaking of Carnage, Marvel lately seems to be trying to invoke this and move him to fight other characters, like Kaine, [[ComicBook/{{Nova}} Sam Alexander]] or ComicBook/{{Deadpool}}.
32* Swarm was originally created as a ComicBook/{{Champions|1975}} villain, but soon became far more associated with Spider-Man.
33* Fin Fang Foom was originally a general Franchise/MarvelUniverse monster. He became an ComicBook/IronMan villain to the point that he has appeared in both ''WesternAnimation/IronManTheAnimatedSeries'' and ''WesternAnimation/IronManArmoredAdventures'' cartoon series, was featured in [[WesternAnimation/TheInvincibleIronMan the animated movie]], and was considered as a foe for the live-action ''Film/IronMan1'' movie... presumably without [[MonsterModesty the purple shorts]]. He still shows up in a FreezeFrameBonus, [[http://www.zimbio.com/A+Closer+Look+at+Marvel%27s+Many+Easter+Eggs/articles/5k4dcA3Hvm9/Fin+Fang+Foom+Makes+Appearance on a billboard]].
34* In her first appearance, Moondragon was an Iron Man villain named "Madame [=MacEvil=]." Subsequent appearances would see her take on more of an AntiHero role, with her eventually becoming a member of the Avengers, ComicBook/TheDefenders and the ComicBook/GuardiansOfTheGalaxy.
35* A minor Iron Man villain named Scarecrow, a former acrobat, never battled him after his first appearance; he bounced around quite a bit, battling the X-Men, Captain America and ComicBook/TheFalcon, before becoming an enemy of ComicBook/GhostRider for quite a while; nowadays he's just puttering around.
36* Black Knight (Nathan Garrett) was originally an enemy of ComicBook/AntMan and ComicBook/TheWasp, but was a founding member of the Masters of Evil, the first supervillain team foes for ComicBook/TheAvengers, and then ended up better known as an enemy of ComicBook/IronMan before being replaced by his heroic nephew. It got to the point where in ''WesternAnimation/IronManArmoredAdventures'', he's depicted exclusively as an Iron Man villain.
37* Speaking of Black Knight, Dreadknight was later introduced in the pages of ''Iron Man'' as something of a replacement {{Expy}}, being a knight-themed supervillain with a high-tech lance, a similar costume and even the same flying horse. However, these same qualities have also led him to battle Dane Whitman, the heroic ComicBook/BlackKnight (and Garrett's RedeemingReplacement), with Dreadknight effectively serving as Dane's EvilCounterpart.
38* ComicBook/{{Mephisto}} works well as a deliberate example: He was originally introduced in the ''ComicBook/SilverSurfer'' series, but has spent stints as an adversary of both ComicBook/TheMightyThor and Ghost Rider. To the modern reader, though, he's best known for his role in ''ComicBook/OneMoreDay'', a Spider-Man story. Mephisto is best understood as a member of the RoguesGallery for the wider Marvel Universe, rather than any one hero, which is fitting as he is basically a stand-in for {{Satan}}. He has tangled with nearly every single major hero and several villains, and is a lot more personal for many. He was notably the BigBad of ''ComicBook/TheAvengersJasonAaron'', where it was revealed that there's even a [[AllianceOfAlternates Council of Red]] made up of Mephistos from across the multiverse.
39* Crossfire first appeared as an enemy of ComicBook/MoonKnight in an issue of ''ComicBook/MarvelTwoInOne'', with the two even having a shared past from their time as CIA agents. However, he's since become more associated with Hawkeye and the Scott Lang version of ComicBook/AntMan, particularly since his brother, Darren Cross, was the latter's StarterVillain.
40* Rhino was introduced as a ComicBook/SpiderMan foe but has spent a large chunk of his career battling the Hulk due to him being one of the physically strongest Spider-Man villains. At the very least, it's shared custody.
41* ComicBook/{{Thanos}} first appeared as an enemy of Iron Man. This is because Thanos's creator, Jim Starlin, was offered to write an issue of Iron Man's comic and created Thanos to be the villain for that issue. When Starlin began writing Captain Marvel he reintroduced Thanos and the rest is history. Thanos is now linked with the ''ComicBook/SilverSurfer'' mythos, (Marvel Comics') ComicBook/{{Captain Marvel|MarvelComics}}, and [[ComicBook/Warlock1967 Adam Warlock]]. As of 2021, he’s also become a major villain for his extended family, the ComicBook/{{Eternals}}. Like Mephisto, he's now pretty much a general enemy of the entire lineup of "Cosmic Marvel" characters, if not the whole Marvelverse. Interestingly enough, the ''Franchise/MarvelCinematicUniverse'' reverses this with Thanos being shown in some later films to have started off already a major threat in space (at least personally to his adoptive daughters [[Characters/GuardiansOfTheGalaxyModern Gamora]] and [[Characters/GuardiansOfTheGalaxyModern Nebula]]), but his onscreen debut is ''Film/TheAvengers2012'', where he masterminds the plot and eventually becomes the main threat of the Avengers, and the ArchEnemy and EvilCounterpart of Iron Man, ironically the very character he originally faced.
42* ComicBook/{{Wolverine}} started out as a foe of [[ComicBook/TheIncredibleHulk the Hulk]] before becoming primarily associated with the ComicBook/XMen.
43* Nebula was conceived as the nemesis of the second ComicBook/{{Captain Marvel|MarvelComics}}(Monica Rambeau), but remained a general Avengers villain after Captain Marvel mostly disappeared from the book and focused more personally on Starfox. Then she became a frequent opponent of The Silver Surfer before appearing in Loki's stories when he was trying to reform. Then she joined Gamora's team Graces only to betray Gamora and turn the group against her. Then Nebula became a general Guardians Of The Galaxy enemy.
44* The Celestials originated in Creator/JackKirby's ''ComicBook/TheEternals'', but have since crossed paths with [[ComicBook/TheMightyThor Thor]], the ComicBook/FantasticFour, ComicBook/TheAvengers, and even the ComicBook/XMen.
45* ComicBook/{{Sabretooth}} was a foe of ComicBook/IronFist. Incidentally, Sabretooth was originally intended to be Wolverine's father by creator Creator/JohnByrne (he was based on Byrne's rejected design for Wolverine sans mask), but ended up getting dumped onto the Iron Fist title when Claremont and Cockrum weren't interested. Years later, Claremont decided to bring Sabretooth into the Wolverine fold; though he has yet to be confirmed as his father, he still is his ArchEnemy.
46* Lady Deathstrike first appeared as a supporting character in a Daredevil storyline before becoming integral to Wolverine's story.
47* The first Silver Samurai, another character closely associated with Wolverine and the X-Men, also first appeared fighting Daredevil. And while he's best known as a Wolverine villain now, he's also clashed with ComicBook/ShangChi, ComicBook/BlackWidow and Spider-Man. His son, Shin Harada, originated as a Wolverine villain, but also battled Jane Foster during her time as the new ComicBook/{{Thor|2014}}.
48* Nuke first appeared as an enemy of Daredevil in the iconic ''ComicBook/BornAgain'' storyline, but his ties to Project Rebirth (and, by extension, Weapon X), as well as his general concept of being a crazed SuperSoldier, made him a perfect fit for the likes of Captain America and Wolverine.
49* The Collector first showed up as an Avengers villain, but thanks to his habit of stealing rare artifacts and organisms, he's clashed with the likes of the ComicBook/SilverSurfer, ComicBook/{{Wolverine}}, [[ComicBook/TheIncredibleHulk the Hulk]], and ComicBook/StarLord. The ''ComicBook/ContestOfChampions2015'' series also had him as a general threat who, alongside the Maestro, kidnapped a number of Marvel characters from across the Multiverse to force them to fight to the death.
50* Lucifer started off as a very minor X-Men villain before eventually battling characters like Iron Man and ComicBook/TheFalcon. His successor, Dominus, would later fight the ComicBook/WestCoastAvengers.
51* ''ComicBook/UltimateSpiderMan2000'':
52** Omega Red started off as an X-Men foe before focusing squarely on Wolverine. In the ComicBook/UltimateMarvel universe, Omega Red is primarily a foe of [[ComicBook/UltimateSpiderMan2000 Peter Parker]] and his successor, [[AffirmativeActionLegacy Miles Morales]]. Likewise, ComicBook/{{Deadpool}} made his Ultimate debut fighting Spider-Man (though the arc was also a sequel to an ''ComicBook/UltimateXMen2001'' arc and featured the team).
53** Killer Shrike likewise underwent this, going from a foe to [[ComicBook/TheIncredibleHulk the Hulk]] and ComicBook/IronMan in the classic Marvel Universe, to a foe of Spider-Man in the ultimate Universe.
54** Bolivar Trask is most associated with the ComicBook/XMen in mainstream Marvel continuity, but in the [[ComicBook/UltimateMarvel Ultimate Universe]] he became integrated into ComicBook/{{Ultimate Spiderman|2000}}'s mythos, eventually becoming the BigBad of [[VideoGame/UltimateSpiderMan2005 the video game adaptation]].
55** Likewise, the original Ringer was an enemy of ''ComicBook/TheDefenders'', but made his ''Ultimate'' debut as a Spidey villain.
56* A temporary case - today, the Sandman is best-known as a Spider-Man villain, and he indeed made his first few appearances in ''The Amazing Spider-Man'', but during the '60s and '70s he ''mostly'' pestered the ComicBook/FantasticFour, either solo or as part of [[ThePsychoRangers the Frightful Four]]. In fact, the very first issue of ''ComicBook/MarvelTeamUp'' (a 1972 Christmas special) has Spidey claiming he only fought Sandman once, and the FF are the ''real'' "Sandman experts".
57* The [[PsychoForHire contract killer]] Boomerang, who uses deadly gimmick boomerangs as his weapons, originally started out fighting [[ComicBook/TheIncredibleHulk the Hulk]], before he moved on to become a semi-regular ComicBook/SpiderMan villain after writers realized that trick boomerangs versus the most powerful creature on Earth was a bit of a mismatch. Boomerang even appears in the Uncanny X-Men Platform/{{Nintendo|EntertainmentSystem}} game by LJN even though he's neither a X-Men enemy nor a mutant.
58* Mister Hyde, a villain based on ''Literature/TheStrangeCaseOfDrJekyllAndMrHyde'', started out as a [[ComicBook/TheMightyThor Thor]] villain but would later move on to become a ComicBook/{{Daredevil}} regular, although he also took the time to mess with ComicBook/SpiderMan, ComicBook/CaptainAmerica, ComicBook/GhostRider, and [[ComicBook/TheIncredibleHulk the Hulk]], finally settling in to become a regular foe of Cap, DD and the Big Green Machine. These days he seems to have moved to fighting teen heroes, considering his appearances in both ''ComicBook/YoungAvengers'' and ''ComicBook/AllNewGhostRider''. He was later revealed as the father of ComicBook/DaisyJohnson, and has been a foe of her as well.
59* Cobra, Mister Hyde's sometime partner, also started out as a [[ComicBook/TheMightyThor Thor]] villain. He quickly figured out that his 'powers' of being double-jointed and crawling on his belly didn't make him capable of challenging the god of thunder and became a foe of ComicBook/{{Daredevil}} and ComicBook/CaptainAmerica.
60* In the very early days of the Silver Age Franchise/MarvelUniverse, the ComicBook/FantasticFour's ComicBook/HumanTorch had his own rogues gallery as a solo hero. Two of his mainstays, the Wizard and the Trapster, would later become enemies of the Fantastic Four, with the Wizard becoming an EvilCounterpart to [[ComicBook/MisterFantastic Reed Richards]] and even forming his own EvilCounterpart team in the Frightful Four, of which the Trapster was a charter member. The Trapster and the Beetle, another long-standing enemy of the Torch, would also become recurring enemies of ComicBook/SpiderMan. It's so pronounced that in both the ''Ultimate Spider-Man'' [[ComicBook/UltimateSpiderMan2000 comic]] and [[WesternAnimation/UltimateSpiderMan2012 TV show]], the Beetle is more or less treated as a straight-up Spidey villain (being a founding member of the Sinister Six there). Though during the days he wore his first costume, he fought Daredevil more often, only to completely abandon him with his upgrade, choosing Iron Man as a secondary nemesis. The Eel also originally debuted as a foe of the Human Torch before becoming a semi-regular ComicBook/{{Daredevil}} villain.
61* Current Beetle debuted as a one-time enemy of ComicBook/CaptainAmerica, but is now better known for her role in ''ComicBook/TheSuperiorFoesOfSpiderMan''. Of course, Spider-Man was TheGhost in that series, and writer Nick Spencer wrote her into a DatingCatwoman scenario with Scott Lang during his later run on ComicBook/AntMan, so she probably rates more highly in Scott's Rogues Gallery at this point. She was fully shunted into Spider-Man's gallery come ''ComicBook/TheAmazingSpiderMan2018''.
62* Many of the enemies the various members of ComicBook/TheAvengers had faced as solo heroes would later become enemies of the team as a whole, with characters like [[MadScientist Egghead]], an enemy of ComicBook/AntMan, a.k.a. Henry Pym; [[Characters/CaptainAmericaCentralRoguesGallery Baron Zemo]], (an enemy of ComicBook/CaptainAmerica and the founder of the original Masters of Evil); ComicBook/{{Loki}}, an enemy of ComicBook/TheMightyThor (unique in that he ''also'' was their StarterVillain); and the Mandarin, the ArchEnemy of ComicBook/IronMan, all becoming some of the Avengers' worst enemies. This would also get inverted. The first incarnation of the Masters of Evil featured the Black Knight as a foil for Wasp and Giant Man and Radioactive Man as the foil for Thor. Soon after, both became regular enemies of ComicBook/IronMan.
63* Speaking of [[Characters/CaptainAmericaCentralRoguesGallery Baron Zemo]], though he's best known as an enemy of the original Captain America, he's also menaced Steve's successors to the mantle, ComicBook/BuckyBarnes and [[ComicBook/TheFalcon Sam Wilson]]. Zemo's connections to the Thunderbolts have also given him a grudge against ComicBook/{{Hawkeye}}, leading to appearances as a major antagonist in both ''Hawkeye: Blind Spot'' and ''ComicBook/OldManHawkeye''. Lastly, he clashed with ComicBook/ThePunisher during the latter's brief stint as the new ComicBook/WarMachine, and subsequently appeared as one of the main villains of the ensuing 2018 ''Punisher'' relaunch.
64* The Multiversal Masters of Evil from ''ComicBook/TheAvengersJasonAaron'' are an interesting variation on the trope. The group is comprised of [[Characters/MarvelComicsDoctorDoom Doom Supreme]], [[Characters/MarvelComicsThanos Kid Thanos]], Ghost Goblin ([[Characters/MarvelComicsNormanOsborn Green Goblin]] as a Spirit of Vengeance), King Killmonger ([[Characters/BlackPantherEnemies Erik Killmonger]] inside the Asgardian Destroyer armor), and Dark Phoenix ([[Characters/MarvelComicsMystique Mystique]] as a Phoenix Force host), all of whom do traditionally have some connection to the Avengers or at least one of their individual members. However, with the exception of Kid Thanos (who is simply a child version of Earth-616's Thanos), the Masters are all Variants from alternate realities, and thus have no real history with the Avengers of Earth-616.
65* Graviton is primarily an Avengers villain, but was also a major recurring adversary of the original ComicBook/{{Thunderbolts}}. He's also faced other heroes like Shuri and Miles Morales.
66* Michael Korvac was first introduced as a one time enemy of ''ComicBook/TheDefenders'', but later became best known as the main antagonist of ''ComicBook/TheKorvacSaga'' in ''ComicBook/TheAvengers''.
67* ComicBook/TheEnchantress is normally an enemy of Thor and/or The Avengers (she's been known to tangle with the ComicBook/ScarletWitch on occasion), but she has branched out - at one point she became the arch-enemy of ComicBook/{{Dazzler}}, of all people; recent events have had her teaming up with the new Lady Deathstrike and Typhoid Mary to counter the X-Men (Mary herself is normally an enemy of Daredevil)
68* [[Characters/MarvelComicsMystique Mystique]] first appeared in ''ComicBook/MsMarvel'' and was originally slated to be her ArchEnemy. She's pretty much entirely an X-Villain nowadays, and her history with Ms. Marvel (such as killing her boyfriend) has been all but forgotten. She did return to torment Ms. Marvel in Carol's later series.
69** As far as individual X-Men, She tends to have the most conflict with Rogue (her adopted daughter), Nightcrawler (her biological son), and Wolverine (her former lover).
70* The Sons of the Serpent originated in Creator/StanLee's run on ''ComicBook/TheAvengers'', but later had memorable battles with ComicBook/{{Daredevil}} and ComicBook/TheDefenders. Their status as [[PoliticallyIncorrectVillain a white supremacist organization dedicated to ridding America of minorities]] has also led to run-ins with the likes of [[ComicBook/TheFalcon Sam Wilson]], ComicBook/MonicaRambeau and the ComicBook/YoungAvengers.
71* This goes for a lot of the evil organizations of the Marvel Universe like ComicBook/{{HYDRA}} (originally enemies of ComicBook/NickFury and ComicBook/{{SHIELD}}), A.I.M. (originally enemies of Captain America) and the Hand (originally enemies of ComicBook/{{Daredevil}}), all of whom have fought various solo superheroes and teams as general threats to the Marvel Universe.
72* ComicBook/{{Apocalypse}} first appeared in ''ComicBook/XFactor'' as the leader of the Alliance of Evil (a role, again, originally intended for the Owl) eventually becoming their BigBad, getting killed, and, upon resurrection, graduating to become one of the ComicBook/XMen's most powerful foes and being {{retcon}}ned as ComicBook/{{Cable}}'s archenemy. The former might not be quite enough to qualify as this trope since the incarnation of X-Factor that had Apocalypse as the BigBad consisted of the original five X-Men, making the whole thing X-Men in all but name to begin with. Cable, on the other hand, while very much an X-Men related character, especially due to him being the future son of ComicBook/{{Cyclops|MarvelComics}} and ComicBook/JeanGrey, has his own distinct rogues gallery that usually only overlaps with the X-Men during crossover events. Since Jason Aaron took over the Thor title and the beginning of ''ComicBook/UncannyAvengers'' (where he and Thor were manipulated into a confrontation by Kang), he also became a part time enemy of Thor - albeit usually in flashbacks when fighting a pre-Mjolnir Thor, who holds something of a grudge against him for a beating that Apocalypse handed out to him. Since Apocalypse has been worshipped as a god, and is a PhysicalGod in terms of raw power anyway, it's fitting.
73* Deathbird started as a Ms. Marvel villain before becoming a recurring foe of the ComicBook/XMen in general and ComicBook/ProfessorX's girlfriend Lilandra (her sister, as it turns out) in particular. Like Mystique above, this is a result of Creator/ChrisClaremont creating a villain for one book, then moving her to another when the first was canceled.
74* The Brood are another Claremont example, having first been introduced as enemies of the X-Men before going on to fight other characters like Carol Danvers, the Avengers and the Guardians of the Galaxy.
75* In his initial few appearances, Characters/KangTheConqueror was a ComicBook/FantasticFour villain called Rama-Tut, with it even being implied that he was a future descendent of Doctor Doom. After taking on his far better known name and appearance as Kang, he primarily battled the Avengers, though he still shows up to menace the FF and other heroes from time to time.
76* The first Moonstone was a ComicBook/CaptainAmerica villain, and the woman who would eventually steal his powers as the second Moonstone was initially an EvilMinion who was of little concern to Captain America. When she became a full fledge super villain she started off as a foe of [[ComicBook/TheIncredibleHulk the Hulk]], but became more of a general Avengers villain after joining the Masters of Evil, forming a direct rivalry with the second ComicBook/{{Captain Marvel|MarvelComics}}(Monica Rambeau). Then she became a rival to Baron Zemo and the third Captain Marvel/second Photon, Genis-Vell, during ''ComicBook/{{Thunderbolts}}''. Then during ''ComicBook/DarkReign'', she was positioned as ComicBook/MsMarvel's EvilCounterpart in Norman Osborn's ComicBook/DarkAvengers. She continues to oppose ComicBook/CarolDanvers as she becomes Captain Marvel #6, though not always willingly.
77* June Covington, aka "Toxic Doxie", started off as one of Norman Osborn's allies from his limited series. She went on to menace the ComicBook/NewAvengers as the ComicBook/DarkAvengers' impostor Scarlet Witch, but has since settled on terrorizing ComicBook/{{Captain Marvel|MarvelComics}}. This is because June was originally created by Creator/KellySueDeconnick, who then brought the character over to the ''Captain Marvel'' book once she started writing it.
78* Blackout was originally an obscure ComicBook/{{Nova}} villain, but is probably best remembered for his role in Creator/RogerStern's ''ComicBook/TheAvengers'' run, where he battled the team as part of the [[LegionOfDoom Masters of Evil]]. On a more specific level, his powers were used to counteract those of Captain Marvel #2(Monica Rambeau).
79* Arcade debuted in the pages of ''Marvel Team-Up'', a title that had Spider-Man teaming up with other Marvel heroes, but these days is better known as an ComicBook/XMen villain. He did resurface in TheNewTwenties in ''ComicBook/TheAmazingSpiderMan2018'' as part of the ''ComicBook/{{Hunted}}'' arc before jumping back to the X-Men in ''ComicBook/{{Hellions}}''.
80-->'''Young!Cyclops:''' Uh, what're you guys doing here?\
81'''Deadpool:''' Hi-ya, Mini-Cyclops! We got a present for you!\
82'''Spider-Man:''' We know he's not a mutant, but even though I fought him first he's somehow become part of the whole X-Men deal. Which makes him your deal.
83** Arcade was the main villain for young Marvel superheroes for a time, trapping the ComicBook/AvengersAcademy kids and the [[MediaNotes/TheModernAgeOfComicBooks Modern Age]] Young Allies in Murderworld, and doing the same in ''ComicBook/AvengersArena'' with more teen superheroes.
84* The demon Blackheart debuted in ''Daredevil'', though now spends most of his time messing with ComicBook/GhostRider, even appearing as the villain in [[Film/GhostRider2007 the movie adaptation]]. He also shows up in ComicBook/XMen from time to time (amongst others), even at one point serving as the Black King of the Hellfire Club. He’s also had run-ins with ComicBook/MilesMorales and ComicBook/TheFalcon.
85* The Marvel [[PublicDomainCharacter version]] of Ball-Hadad was originally a Wolverine, but has since become more associated with Ghost Rider.
86* The death angel Lazaer, whom frequently poses as the more famous Azrael/Azriel, was originally an enemy to the Marvel Comics version of Venus, but has since become more associated with Wolverine.
87* Ghost Rider villain Night Terror eventually became a ComicBook/{{Blade}} antagonist. Although it did not last too long, since he really only lasted in the first place because none of Ghost Rider attempts to kill him stuck, but Blade was actually equipped end him for good.
88* The [[Characters/DaredevilCentralRoguesGallery Purple Man]] originated as a Daredevil villain, but has since become the ArchEnemy of ComicBook/JessicaJones.
89* Minor-league ComicBook/IronMan villains [[AnIcePerson Blizzard]] and [[PlayingWithFire Firebrand]] started out fighting Shellhead, but eventually transitioned to fighting street-level heroes like ComicBook/SpiderMan after Tony Stark's equipment began to completely outclass theirs. And Shellhead's greatest foe, The Mandarin, took time out - primarily in the 60s and 70s - to deal with other characters. The very first ''Avengers'' annual had Enchantress and Executioner, Living Laser, the original Power Man and the Swordsman working for him to distract the Avengers from his plan of broadcasting worldwide hate-rays. The late 60s had him clash with [[ComicBook/TheIncredibleHulk the Hulk]] a few times (one time getting Nick Fury involved, another involving the Sandman, normally a Spider-Man foe), another time he kidnapped a peacemaker who was rescued by Captain America, and still another time saw him encounter the Inhumans in an attempt to gain a Makluan artifact. Since then though, he's been sticking with Iron Man.
90* Living Laser originally appeared as a foe of ComicBook/TheAvengers, fixated on ComicBook/TheWasp, before later becoming an enemy of ComicBook/IronMan.
91* Moses Magnum started out fighting Spider-Man and ComicBook/ThePunisher, but seems to have eventually settled on antagonizing ComicBook/BlackPanther. Thematically, Magnum and T'Challa are a perfect fit, and ''WesternAnimation/IronManArmoredAdventures'' chose to have Magnum [[YouKilledMyFather murder]] T'Chaka instead of Klaw.
92* Klaw is a Black Panther villain, but he's also a fairly prominent enemy of the Fantastic Four (debuting in their comic, where Black Panther also debuted), and has menaced Daredevil a number of times as well. Generally, Klaw can be counted on to antagonize anyone associated with his original foes, the FF and Black Panther through RevengeByProxy. He's menaced the Avengers a few times, even if Black Panther isn't in the line up and will go after the next available hero if his original target isn't around. After his first defeat and transformation into living energy, his first act is to travel to New York and get revenge on the FF for helping Black Panther.
93* The Absorbing Man, who was able to [[PowerCopying mimic and absorb the physical properties of anything he touched]], started out as a recurring enemy of ComicBook/TheMightyThor and remains a charter member of Thor's RoguesGallery. However, he's also tangled with [[ComicBook/TheIncredibleHulk the Hulk]] enough times that it's arguably shared custody.
94* ComicBook/DoctorDoom was created to be the main nemesis of the ComicBook/FantasticFour. While he still maintains that role to the present day, he has since become one of the overall Big Bads of the Marvel Universe and has fought pretty much every single Marvel hero. Most prevalent are his tussles with ComicBook/BlackPanther, which makes sense because Panther was originally introduced as a Fantastic Four ally and a GoodCounterpart to Doom in the first place. Doom is also known for his roles in classic ComicBook/IronMan stories and the graphic novel ''Triumph & Torment'' where he meets ComicBook/DoctorStrange. Even other villains are not safe from Doom. He will gladly co-op with the heroes if he feels it serves his interests (of course, [[ChronicBackstabbingDisorder once the interests are served...]]) This is so pronounced that it's even reflected in marketing. For instance, Creator/{{Hasbro}}'s "Titan Hero" action figure line usually references the installment each hero or villain comes from (''Film/IronMan3'', ''WesternAnimation/AvengersAssemble'', ''Film/ThorTheDarkWorld'', ''Film/GuardiansOfTheGalaxy2014'', etc.), but the packaging for the Doctor Doom figure contains no indication that he belongs to the Fantastic Four franchise. One of the most famous storylines with him as the BigBad was ''ComicBook/AvengersTheChildrensCrusade''. It involved many named characters such as the ComicBook/YoungAvengers, ComicBook/TheAvengers, ComicBook/XMen, and even [[ComicBook/XFactor2006 X-Factor]] -- yet the first family themselves were no shows.
95* ComicBook/{{MODOK}} was originally created as a foe for ComicBook/CaptainAmerica. However, in his role as leader of AIM, he's increasingly become an antagonist of ComicBook/IronMan. And then [[ComicBook/TheIncredibleHulk the Hulk]], as he created ComicBook/RedHulk.
96* ''ComicBook/{{Annihilation}}'' has the ComicBook/FantasticFour's long-time foe Annihilus launching a devastating attack on the universe, uniting cosmic heroes like ComicBook/{{Nova}} and the ComicBook/SilverSurfer against him. Even through Annihilus returned a few years later to fight the first family again, he is now generally considered a threat to the entire universe.
97* ''ComicBook/AnnihilationConquest'' does a similar thing - Avengers villain (created by ComicBook/AntMan) ComicBook/{{Ultron}} takes control over the Phalanx, a race mostly known for their fights with the X-Men, as well as a few lesser-known villains like the Avengers' enemy Super-Adaptoid or the Fantastic Four's foe Blastaar, and then goes against cosmic heroes. Ultron later returned to fighting the Avengers, though.
98* In a similar vein, ''ComicBook/WarOfKings'' is driven by conflict between the Kree Empire, ruled by ComicBook/TheInhumans, and the Shi'Ar Empire, ruled by X-Men foe Vulcan. Time will show which group Vulcan will stick to antagonizing.
99* The Super-Adaptoid was introduced as an enemy of Captain America, but very quickly moved on to fighting the X-Men and Avengers as well (fittingly, as [[AllYourPowersCombined it originally possessed the combined powers of the latter team at the time]]). Nowadays it's mostly considered an Avengers villain, though that hasn't stopped it from also mixing it up with the likes of Spider-Man and the Hulk on occasion.
100* While [[ComicBook/SubMariner Namor]]'s Silver Age return pegged him as a Fantastic Four villain and ComicBook/MisterFantastic's romantic rival, Stan Lee and Jack Kirby quickly established him as a threat to the wider Marvel Universe by having him also fight the Avengers and X-Men. His constant HeelFaceRevolvingDoor tendencies have led him to clash with a great many Marvel heroes over the years, including ComicBook/BlackPanther and the ComicBook/SquadronSupreme.
101* The Super-Skrull originated as a ''ComicBook/FantasticFour'' foe (even having [[AllYourPowersCombined the combined abilities of all four members of the team]]), but quickly became a general cosmic villain (and sometimes AntiVillain), fighting Kree-based heroes like [[ComicBook/{{Captain Marvel|MarvelComics}} Mar-Vell]] and ComicBook/CarolDanvers and showing up in ComicBook/SilverSurfer's book during the 90s. He's also faced off against other Earth heroes like Thor, [[ComicBook/TheIncredibleHulk the Hulk]], the Avengers, Doctor Strange, [[ComicBook/SubMariner Namor]] and even Tigra on occasion.
102* This applies to the Skrulls as a whole. They began as enemies of the Fantastic Four, but gradually became a threat to the entire Marvel Universe, which was cemented by ''ComicBook/SecretInvasion''. Ditto for the Kree, the archenemies of the Skrulls.
103* [[EldritchAbomination Shuma-Gorath]] was actually first mentioned in a Creator/RobertEHoward short story, but has been better known for his classic fights against ComicBook/DoctorStrange. He more or less lost his association with the good doctor when he [[UnexpectedCharacter unexpectedly appeared in]] ''VideoGame/MarvelSuperHeroes'', [[AdaptedOut where Strange was absent]]. Due to the Howard connection, Shuma also menaced ComicBook/ConanTheBarbarian in his Marvel series, as well as the ''ComicBook/SavageAvengers'' when Conan was part of that group. ''ComicBook/TheThanosImperative'' and a few other appearances helped him get upgraded to universal threat, like Mephisto or Thanos, and he later served as a StarterVillain for ComicBook/LukeCage's incarnation of the ''ComicBook/MightyAvengers2013''. Similarly, Nightmare started as a ComicBook/DoctorStrange foe, but has since then fought with pretty much everybody.
104* ComicBook/{{Juggernaut|MarvelComics}} was and still is one of the ComicBook/XMen's most iconic and recurring adversaries, but quite possibly the most famous comic book story he had ever been in was ''ComicBook/NothingCanStopTheJuggernaut'', where he tangled with ComicBook/SpiderMan. The story was meant to establish Spidey as the ultimate underdog, where the Juggernaut, a character Spidey normally never has to deal with and far outside his weight class, is causing trouble and Spider-Man is the only one there who can stop him. This battle got a modern sequel in the ''The Gauntlet'' arc.
105** Juggernaut also has a long-standing rivalry with [[ComicBook/TheIncredibleHulk the Hulk]], as the irresistible force to Hulk’s immovable object, and has clashed with him many times over the years.
106* Demogorge the God Eater and Amatsu Mikaboshi both debuted as antagonists of ComicBook/TheMightyThor. To modern readers they are probably known as enemies and [[EnemyMine occasional allies]] of ComicBook/TheIncredibleHercules.
107* ComicBook/ThePunisher has few reoccurring villains due to his deadly nature but one of his few villains, Jigsaw, started off as a Spider-Man villain, although his introductory story did involve Punisher as well. Punisher himself was a Spider-Man villain; however he was more of an antagonistic AntiHero and now has his own titles where he scuffles with every street level hero when he's not massacring normal criminals.
108* [[LegacyCharacter Jimmy Natale's Vulture]] started off as a Spider-Man villain before moving over to the Punisher's corner of the Marvel U during Creator/GregRucka's run. [[KilledOffForReal He didn't survive the trip]].
109* The crossover event ''ComicBook/ActsOfVengeance'' best describes this trope. It involves the very idea of [[OpponentSwitch a wide array of super-villains facing heroes they had never met (or at least were villains that weren't part of the heroes' regular gallery)]]. Such examples were ComicBook/AlphaFlight fighting Scorpion, Spider-Man (who was granted cosmic powers at the time) fought Goliath, The Brothers Grimm, Titania, Magneto, Graviton, Trapster, Dragon-Man, and the Tri-Sentinel. Daredevil fought Ultron, Thor fought Juggernaut, Mandarin appears in the X-Men issues, and Rusty and Skids of the ComicBook/NewMutants battle the Vulture. Even Magneto went against the ComicBook/RedSkull for [[BerserkButton very obvious reasons]] (Magneto (a Holocaust survivor) barely tolerated the Red Skull as a co-conspirator under the impression that he was a modern villain using the Skull's mask and image to frighten people. When he realized the Skull was the actual protege of Hitler and WWII war criminal . . . he [[FateWorseThanDeath buried the Skull in a light-less fallout shelter with a dozen jugs of water and sealed it shut]].) Similarly the event ''ComicBook/InfinityWarps'' does the same thing, being an homage to ''Acts of Vengeance''. Across the merged universe it takes place in, superheroes find themselves under attack by other people's enemies.
110* Grey Gargoyle was always a Thor foe. However, he's faced Captain America and Falcon a few times and got on Nick Fury's attention when he hired himself out to AIM. He's basically faced most of the major Marvel heroes following ''ComicBook/ActsOfVengeance'': Hulk, She-Hulk, Spider-Man, Iron Man, and the Fantastic Four. It probably helped that he appeared on the cover of an Iron Man comic in the '90s that led to him being cast in ''WesternAnimation/IronManTheAnimatedSeries'' as one of Mandarin's henchmen. In the 2024 Cable series, he's gone off and is in the way of the time-travelling X-Men soldier.
111* Baron von Strucker was introduced as ComicBook/NickFury's ArchEnemy, but, as the leader of ComicBook/{{HYDRA}}, he's also clashed with the likes of ComicBook/{{Daredevil}}, Captain America, the Avengers, ComicBook/{{Wolverine}}, Black Panther and the ComicBook/{{Thunderbolts}}. A memorable issue from Creator/ChrisClaremont’s ''X-Men'' run also revealed that Strucker played a key role in the shared backstory of ComicBook/ProfessorX and [[Characters/MarvelComicsMagneto Magneto]], having fought against both mutants back when they were young men in the years after World War 2.
112* Marv Wolfman originally created ComicBook/BlackCat as an enemy for ComicBook/SpiderWoman; however, Wolfman was transferred to ''Spider-Man'' before he could introduce her, and he brought her with him.
113* Thanks to sharing continuity, Marvel's [[ComicBook/GIJoeARealAmericanHeroMarvel G.I. Joe]] series had an entire story arc with [[ComicBook/TheTransformersMarvel Megatron]] as the antagonist.
114* An {{inver|tedTrope}}sion happened to The Pride - they were always antagonists of the ''ComicBook/{{Runaways}}'' and it would be pretty hard to introduce them fighting any other superheroes while their entire point was they kept their operations under their radar. That was the case until the creation of [[ComicBook/NewAvengers Avengers Illuminati]] who were also working in secret from the entire Marvel superheroic community. So of course there exist comics that revealed the two groups clashed back in the days when the Runaways were still only kids.
115* After Doctor Sun was defeated in ''ComicBook/TheTombOfDracula'' by the joined forces of Dracula and the vampire hunters, he went to antagonize ComicBook/{{Nova}} and the ComicBook/FantasticFour.
116* ComicBook/{{Dracula|MarvelComics}} himself also qualifies, though he didn't start out as anyone's rogue and happened to fight any superhero who crossed his way like Thor, Silver Surfer or Dr. Strange. With that said, he went on to became a recurring antagonist to ComicBook/{{Blade}} (who, ironically, starred in Dracula's own series and became hugely popular afterwards) and regularly clashed with the X-Men-related characters more than with any other hero, such as ComicBook/{{Storm|MarvelComics}} (leading to one alternate reality where Storm was a vampire), Old Man Logan and Deadpool. It was revealed that even X-Men's BigBad ComicBook/{{Apocalypse}} was Dracula's ArchEnemy at one point.
117* MadScientist Dr. Bong began life as the foe of ComicBook/HowardTheDuck, but recently he seems to have largely migrated over to being part of ComicBook/{{Deadpool}}'s supporting cast (probably because of Howard not having a regular title for years). Deadpool has also tangled with ComicBook/{{Bullseye|MarvelComics}} enough as a FriendlyEnemy that it's practically shared custody.
118* The Crime Master and Jack O' Lantern were traditionally Spider-Man villains, but after [[ComicBook/{{Venom}} Agent Venom/Flash Thompson]] got his own book they made the jump with him and settled down as his archenemies.
119* Cobalt Man was originally a very minor Silver Age ComicBook/XMen villain, but soon drifted away from that corner of the Marvel Universe and instead fought characters like [[ComicBook/TheIncredibleHulk the Hulk]] and ComicBook/TheDefenders.
120* Black Tarantula debuted as a Spider-Man villain, but most of the modern readers are probably more familiar with him undergoing a HeelFaceTurn and becoming a supporting character for Daredevil, or with [[LegacyCharacter his son taking the name]] and antagonising ComicBook/SpiderGirl in her universe.
121* [[http://brevoortformspring.tumblr.com/post/120237862353/no-appearances-such-as-what-you-suggest-would This is actually part of the Marvel creative process]] - villains are catalogued by the hero they fight with and if you have to use any, you need to ask the editor overseeing that character at the moment. But if you write a very good story with the villain or use him a lot, he might be moved. For example, when ''ComicBook/UncannyAvengers'' was heavily using the Red Skull, writers had to ask that book's editor for permission to use him, instead of the ''Captain America'' editor.
122* Samuel Saxon started out as a Daredevil villain, both under his nickname "Starr" Saxon as well as the second Mister Fear. However, after being killed off in a Daredevil issue and receiving an EmergencyTransformation, he's pretty much exclusively been a Captain America villain as the android Machinesmith.
123* While [[Characters/MarvelComicsMagneto Magneto]] is primarily known for his [[HeelFaceRevolvingDoor complicated]] relationship with the X-Men, he has tangled with all of Marvel's major heroes as well, particularly the Avengers, Fantastic Four, Thor, and Spider-Man. A key moment in his backstory, where he was deaged to infancy, actually occurred after a fight against ComicBook/TheDefenders.
124* With Peter Parker becoming head of Parker Industries during the ComicBook/AllNewAllDifferentMarvel event and Spider-Man dealing with bigger foes, his previous street-level Rogues Gallery is now being handled by ComicBook/MilesMorales, ComicBook/SpiderWoman, and ComicBook/{{Silk}}. Both Silk and Miles have dealt with ComicBook/BlackCat, and Spider-Woman has gone up against Hobgoblin.
125* Speaking of Spider-Woman, Morgan Le Fay used to be her arch-nemesis, but now she's a general Marvel Universe villain, mainly tangling with the Avengers. This included an encounter with the ComicBook/DarkAvengers, due to her targeting Doctor Doom for revenge. In the [[ComicBook/SpiderWoman2014 2014 volume]], Spider-Woman mainly fought C-list/D-List villains such as Tiger Shark (a traditional ComicBook/SubMariner villain), the Sandman (a ComicBook/SpiderMan villain), and the Blizzard (traditionally an ComicBook/IronMan villain).
126* Roxxon Energy, the evil energy MegaCorp, are mostly known for pestering Iron Man, but are also enemies of a few different iterations of Deathlok, most notably Michael Collins, who they transformed into a cyborg commando against his will because [[HeKnowsTooMuch He Knew Too Much]]. They later became a recurring problem for Kaine as the Scarlet Spider, and under new CEO Dario Agger (who's also a Minotaur), they've mainly been an enemy to both Thor and [[ComicBook/Thor2014 Lady Thor]]. Agger, in turn, has since branched out to the ComicBook/ImmortalHulk. In the ComicBook/UltimateMarvel continuity, Roxxon was more of a general villain to almost every hero, being the cause of how most heroes got their powers and behind many atrocities. As the Ultimate Marvel line dwindled down, Roxxon was exclusively a problem for Miles Morales/Spider-Man and his friends. So much so, in the video game ''VideoGame/SpiderManMilesMorales'', Roxxon and their CorruptCorporateExecutive Simon Krieger are the main antagonists. They would again become a pain for Miles in the 616-continuity in ''ComicBook/Champions2020'', along with the other Champions.
127* The general public now knows Ronan the Accuser as the villain of the 2014 ''Film/{{Guardians Of The Galaxy|2014}}'' film, but he actually debuted as a ''ComicBook/FantasticFour'' antagonist, and is now in fact [[HeelFaceTurn not much of a villain at all in the comics]] (to the point of ''teaming up'' with the Guardians in one of his most recent appearances)
128* Following the disbanding of the Fantastic Four after ''ComicBook/SecretWars2015'' many of their enemies went on to face other heroes. Terrax went up against the X-Men.
129* Madame Masque for most of her existence was an ComicBook/IronMan villain, but since the 2010s, she has become the ArchEnemy of [[Characters/MarvelComicsKateBishop Kate Bishop]] (purely out of spite because Kate once knocked her out and [[MuggedForDisguise stole her costume]]). First Masque antagonized Kate in her solo arc in ''ComicBook/Hawkeye2012'', then again in ''ComicBook/Hawkeye2016'', and again in ''ComicBook/WestCoastAvengers2018''. In the the 2020s, she also picked up a few magic tricks and ended up tangling with Dr. Strange.
130* Alex Wilder, the original leader of the ''ComicBook/{{Runaways}}'', was revealed to have been a [[TheMole mole]] all along during ''The Good Die Young'' arc, fanatically loyal to his parents and the Pride's cause, only to be killed shortly after by the Gibborim. When he was resurrected over ten real world years later, he would eventually become a villain in ''[[ComicBook/HeroesForHire Power Man and Iron Fist]]''. The same story had him in an EvilVersusEvil situation with Spider-man villain Tombstone, with Luke and Danny caught in between. In final issue, as they're beating each other up, frustrated Luke even wonders why he keeps having to deal with Tombstone all of sudden.
131* Chemistro was originally an enemy of [[ComicBook/LukeCage Power Man]] and ComicBook/IronFist, but over time moved on to fight other heroes like Iron Man and the ComicBook/NewAvengers.
132* Invoked in ''ComicBook/MsMarvel2014''. One 2018 story has the Shocker, normally a C-list Spider-Man villain, get so tired of getting smacked around by everyone in New York City that he upped and moved to New Jersey and made himself Kamala's new arch-nemesis because dealing with a teenager is ''much'' easier than the rest of New York. Kamala, who is already dealing with usual teenager problems and wonky powers, is not amused.
133* During the 70s, there was a giant robot known as Red Ronin, who was designed to battle Franchise/{{Godzilla}}. It did so and later turned into an ally for the giant green lizard. When Marvel lost the rights to Godzilla, Red Ronin ended up being turned into a basic foe for the Marvel Universe as a whole, usually taken over by some random villain to wreck havoc and let the heroes trash. Doctor Demonicus was also created as a Godzilla villain, but went on to face off against Iron Man and the ComicBook/WestCoastAvengers when the Big G’s rights returned to Creator/{{Toho}}.
134* ComicBook/{{Taskmaster}} debuted as an Avengers foe, and while still commonly associated as a villain to them, he's also antagonized individual members, particularly Captain America. He's also been a villain to [[ComicBook/AntMan Scott Lang]], the latter even thinking of him as his ArchEnemy (he isn't), and has tangled with Spider-Man a number of times. He's also known for his longtime rivalry with ComicBook/{{Deadpool}}. Really, all that matters is if he's getting paid, which naturally leads to him fighting a number of different people.
135* ComicBook/CloakAndDagger's 2018 run had them menaced by Mr. Negative, traditionally a Spider-Man foe. Thematically, he makes a lot of sense, as the duo represents darkness and light much like Mr. Negative himself. It also helped that they had previous history with him through guest spots in ''Amazing Spider-Man'', including a period of being mind-controlled into working for him, meaning they now have a stronger connection to him than Spidey does. It was also revealed in the ''Dark Reign: Mr Negative'' miniseries that Mr Negative got his powers in the same experiment as Ty and Tandy.
136* Selene is normally a New Mutants or X-Men villain but she's also fought Captain America and his friends even making a big debut to his comics by killing the Hydra version of Captain America.
137* Sunset Bain was introduced as a Machine Man villain, but has since taken to menacing Iron Man. The fact that she runs a rival electronics company made her a natural fit.
138* Many of Marvel's 2019 annuals were themed under the banner ''Acts of Evil'', with no actual story throughline, but a theme of heroes fighting villains they would normally have nothing to do with, such as [[ComicBook/MsMarvel2014 Ms. Marvel]] versus the Super-Skrull, the Punisher versus the Brood, ComicBook/MoonKnight versus Kang the Conqueror and ComicBook/SheHulk versus ComicBook/{{Bullseye|Marvel Comics}}.
139* ''ComicBook/CaptainAmerica'':
140** Creator/TaNehisiCoates' run has Steve uncover a conspiracy of villains and morally grey characters who fought against [[ComicBook/SecretEmpire Hydra takeover of United States]] and then used that to get a clean record and install themselves in power structures in America. This makes him fight or try to navigate around Thunderbolt Ross, Kingpin and Selene, who are more commonly associated with Hulk, Daredevil and the X-Men respectively. Norman Osborn, a Spider-Man villain, also reenters this fold, as does Taskmaster, an enemy of the Avengers and SHIELD, and Zeke Stane, an Iron Man villain. Even Phil Coulson has [[FaceHeelTurn sided]] with them due to a DealWithTheDevil with Mephisto allowing him to come BackFromTheDead following ''Secret Empire''. Meanwhile in ''ComicBook/ImmortalHulk'' Ross' role has been filled by General Fortean, who was previously antagonizing...Ross himself while he was ComicBook/RedHulk. Fortean actually lampshades it, beliving [[ItsPersonal Ross was too personally invested to be effective]] with Hulk and [[NothingPersonal isn't with Steve Rogers]], the latter also applying to him and the Hulk.
141** Rikki Barnes, the female Bucky from ''ComicBook/HeroesRebornCaptainAmerica'' has two villains who could serve as her archenemy -- and both started as enemies of other heroes. The first is ComicBook/{{Onslaught}}, a SplitPersonality of ComicBook/XMen founder Professor Xavier, who killed her twice. The second is The Maker, [[ComicBook/UltimateFantasticFour the]] ComicBook/UltimateMarvel [[AdaptationalVillainy version of]] [[ComicBook/FantasticFour Mr. Fantastic]], who killed her girlfriend in one universe.
142* ComicBook/RawhideKid once fought a villain wielding a [[TheParalyzer paralysis gun]] called the Scorpion. The Scorpion later broke jail, changed his alias to Sting-Ray, and battled another western hero, the Phantom Rider.
143* The ''ComicBook/ExtremeCarnage'' event puts the Friends of Humanity, usually an anti-mutant extremist organization, into the symbiotes' rogues gallery. In-universe, Iron Man notes how strange it is for an old mutant hate group to suddenly go after aliens. One can only surmise, assume, or speculate is that the F.O.H. are unable to go after Krakoa with starting an international incident nor they can afford the luxury or privledge of joining Orchis. So, they could only go after the next best thing: aliens.
144* The Wrecking Crew debuted as [[ComicBook/TheDefenders Defenders]] villains (with the exception of the Wrecker, who was a preexisting Thor baddie), but over time became better known as enemies of the Avengers. In general, they tend to be a fairly popular choice for smaller scale VillainOfTheWeek plots, as their comparatively meager ambitions (usually desiring money rather than world conquest or galactic genocide) makes them perfect filler villains for characters like Wolverine and She-Hulk.
145* The Griffin was created as a ComicBook/{{Beast|Marvel Comics}} villain during the brief period where Hank had a solo feature in ''Amazing Adventures''. After Beast's series was cancelled, Griffin drifted throughout the Marvel Universe as an all-purpose villain of sorts, facing the likes of Spider-Man, ComicBook/WonderMan, the ComicBook/{{Champions|1975}}, Namor and various incarnations of the Avengers. He was also eventually revealed to be the father of Yo-Yo Rodriguez in ''ComicBook/SecretWarriors''.
146* Kulan Gath was originally a foe of Franchise/ConanTheBarbarian in the Conan comic books. He later makes his way into the modern world where he's a foe of the Avengers, X-Men, Spiderman and Doctor Strange all at the same time! And for even further transplanting, when ComicBook/RedSonja became a Creator/DynamiteComics property - he went over there to be her ArchEnemy and still occasionally shows up to give her grief. More recently, he's the BigBad of the ComicBook/SavageAvengers - once more showing that he's a power that can't be dealt with by a solo hero.
147* During ''ComicBook/TheCloneSaga'', there was a man named Judas Traveller, who tailed Peter Parker and Ben Reilly before disappearing near the end of the event. After laying low for 25 years, he resurfaced over in X-Men’s ''ComicBook/TheKrakoanAge'' era as a part of the anti-mutant organization ORCHIS.
148* ORCHIS executive Fei Long first appeared as part of ''ComicBook/TheKrakoanAge'' and while he's still an enemy to the X-Men, he's also got beef with Tony Stark by killing one of Tony's friends and taking over Stark International then using Iron Man technology in Orchis's next-generation sentinels. Plus he blames Tony and the other Avengers for not helping him colonize Mars first before the mutants went and terraformed the planet.
149* The Vox were created as part of the ''ComicBook/DeathOfTheInhumans'' event which essentially [[PutOnABus put the entire franchise on a bus]] by wiping out several of new Inhumans created during the ''ComicBook/{{Inhumanity}}'' and nearly wiping out the Inhuman royal family. Since then, they haven't been seen except for one particular Vox, Vox Supreme who was the BigBad of Carol Danvers/Captain Marvel in her [[ComicBook/CaptainMarvelKellyThompson 2019 volume]].
150* ''ComicBook/HeroesReborn2021'' has multiple instances of this, as it revolves around a world where the ComicBook/SquadronSupreme have supplanted the Avengers as Earth's premier superhero team:
151** ComicBook/{{Batman}} expy Nighthawk gains most of Spider-Man's traditional RoguesGallery, with ComicBook/NormanOsborn serving as his ComicBook/TheJoker-like arch nemesis.
152** ComicBook/{{Superman}} expy Hyperion gains [[Characters/MarvelComicsDoctorDoom Doctor Doom]], the Hulk, the Beyonder, Annihilus and [[Characters/MarvelComicsUltron Ultron]], with most of them positioned as pastiches of traditional Superman rogues (the Hulk as ComicBook/{{Bizarro}}, Mr. Beyonder as Mr. Mxyzptlk, General Annihilus as General Zod and Ultron as Metallo).
153** ComicBook/WonderWoman expy Power Princess gains traditional Thor baddies Mangog, Gorr the God Butcher, Ulik and Hela, as well as traditional Avengers [[ComicBook/TheWasp Janet Van Dyne]], Tigra and [[ComicBook/TheIncredibleHercules Hercules]] (serving as pastiches of Wonder Woman's foes Giganta, ComicBook/{{Cheetah}} and Hercules, respectively), traditional X-Men members [[ComicBook/JeanGrey Phoenix]] and ComicBook/{{Magik}}, and the Venom villain Knull.
154** ComicBook/TheFlash expy the Blur gains the Silver Witch (a version of Characters/ScarletWitch who absorbed the speed of her brother ComicBook/{{Quicksilver}}) as his nemesis, and also fights Ursa Major (here a stand-in for Gorilla Grodd).
155** ComicBook/GreenLantern expy Doctor Spectrum gains a bunch of cosmic villains like Thanos, Ego the Living Planet, the Super-Skrull, Ronan the Accuser, and despite not being cosmic-themed, M.O.D.O.K. and the Circus of Crime. Uatu the Watcher also serves as another of his adversaries despite mostly being a good guy in the mainline universe.
156** As a team, the Squadron also face the Masters of Evil and Mutant Force, enemies of the Avengers and Captain America, respectively.
157** ComicBook/TeenTitans[=/=]ComicBook/YoungJustice expies the Young Squadron battle Deadpool and the Wrecking Crew.
158* In ''ComicBook/IdentityCrisis1998'', two of the foes Spidey faces in trying to clear his name is Bloodstream and Roughhouse, who are normally Wolverine's sparring partners.
159[[/folder]]
160
161[[folder:Films]]
162!!Films
163!!!The following have their own pages:
164[[index]]
165* ''RoguesGalleryTransplant/MarvelCinematicUniverse''
166[[/index]]
167----
168* Kingpin is the primary villain of ''WesternAnimation/SpiderManIntoTheSpiderVerse''. But while he's always been a major enemy of Peter Parker in the comics, he's rarely come into contact with Miles Morales, the central protagonist of the film. The Ultimate Kingpin was also killed off long before Miles was introduced.
169** Similarly, The Spot, who styles himself as Miles' ArchEnemy beginning with ''WesternAnimation/SpiderManAcrossTheSpiderVerse'', is a foe of Peter Parker in the comics, with few encounters to speak of with Miles.
170* Viper started off as a ComicBook/CaptainAmerica foe and is usually an enemy of ComicBook/NickFury and ComicBook/{{SHIELD}} as well (to the point that she's now known as [[ComicBook/{{HYDRA}} Madame Hydra]]). Despite this, she is one of the antagonists in ''Film/TheWolverine''. Understandable since despite her connections to Captain America and S.H.I.E.L.D., she has appeared in several notable Wolverine storylines[[note]]This depiction was InNameOnly however[[/note]].
171[[/folder]]
172
173[[folder: Video Games]]
174!!Video Games
175* ''VideoGame/SpiderManAndTheXMenInArcadesRevenge'': The boss of the second Spider-Man level (first if you don't count the intro stage) is N'astirh, a relatively obscure X-Men villain from the ''ComicBook/{{Inferno|1988}}'' CrisisCrossover.
176* ''VideoGame/SpiderManInsomniac''
177** ''VideoGame/SpiderManPS4'' The original game features [[Characters/MarvelComicsTaskmaster Taskmaster]] as an enemy and boss fight. Though he has fought Spidey before (most notably the ''WesternAnimation/{{Ultimate Spider|Man2012}}-Man'' cartoon), Taskmaster debuted in ''ComicBook/TheAvengers'' and more commonly menaces heroes more heavily associated with that team. Here, while the Avengers do exist, they don't appear in this game, leaving Spider-Man to deal with him.
178** ''VideoGame/SpiderManMilesMorales'': The game's main villain is Simon Krieger, whose comic book counterpart was a TokenMotivationalNemesis for Iron Man and had no connection to neither Peter Parker nor Miles Morales.
179[[/folder]]
180
181[[folder: Western Animation]]
182!!Western Animation
183* ''WesternAnimation/AvengersAssemble'' uses Impossible Man, another ComicBook/FantasticFour enemy, as well as Doctor Doom. [[LegionOfDoom The Cabal]], originally created as the EvilCounterpart of ComicBook/TheIlluminati, act as the first main antagonists, founded by Captain America's ArchEnemy Red Skull and his other enemy MODOK (whom is more acknowledged here by his later encounters with Iron Man), with Dracula, ComicBook/SubMariner rogue Attuma, and Hyperion (a member of the ComicBook/SquadronSupreme, though his overall depiction is closer to the villainous Squadron Sinister version) also added. Later arcs find ways to add Thanos and the Black Order (though CrisisCrossover events do see Thanos face the team in the comics despite being better known for his encounters with cosmic heroes), a new Cabal featuring [[spoiler: the Leader, Zola, Enchantress, and Loki]], all enemies of [[spoiler:Hulk, Captain America, and Thor, though Loki was the Avengers' original StarterVillain]], and Madame Masque, whom normally faced Iron Man and Hawkeye (Kate Bishop), was used in a season that was heavily centric to ComicBook/BlackPanther, just to name a few, that same season mainly having his enemy Erik Killmonger as the main antagonist.
184* ''WesternAnimation/TheAvengersEarthsMightiestHeroes'' essentially made the ComicBook/BlackPanther villain Klaw into an ComicBook/AntMan foe, as Ant-Man is the one who mangles his hand and later comes up with the strategy to defeat him. This left Black Panther without an ArchEnemy or someone to yell YouKilledMyFather at, so the writers made Man-Ape into his father's murderer instead. Klaw does still participate from the shadows, but its only because T'Chaka's fight with Man-Ape was really a TrialByCombat fight to the death for the throne, where Klaw's sabotage gave Man-Ape the advantage and victory.
185* The sole costumed supervillain to show up in the first season of ''WesternAnimation/HitMonkey'' is Lady Bullseye, who is an enemy of ComicBook/{{Daredevil}} in the comics.
186* ''WesternAnimation/HulkAndTheAgentsOfSMASH'' has put the Hulks up against Annihilus, Blastaar, and Ego, the Living Planet, all longtime ''ComicBook/FantasticFour'' headaches, and Doctor Doom above especially. Bonus points for ''ComicBook/XMen'' foe Sauron. However, TheManBehindTheMan villain of the series is the Leader, who ''is'' a Hulk villain.
187* In ''WesternAnimation/TheIncredibleHulk1982'', some episodes pit the Hulk against other heroes' enemies.
188** Spider-Man foe Doctor Octopus is the villain in "Tomb of the Unknown Hulk".
189** "Prisoner of the Monster" features Iron Man adversary Spymaster as the antagonist.
190** "Bruce Banner Unmasked" has the Hulk fight the Puppet Master, whose usual adversaries the Fantastic Four get no acknowledgement aside from his step-daughter Alicia Masters having a bust of the Thing among her statues of Marvel characters.
191** The forces of Hydra are fought in "Enter: She-Hulk", when the organization is ordinarily an enemy of S.H.I.E.L.D. or Captain America.
192* The Mad Thinker and Awesome Android pop up in ''WesternAnimation/IronManArmoredAdventures'' as enemies (and classmates) of Tony and his buddies. In the comics, they're traditionally enemies of the ComicBook/FantasticFour, even in the ComicBook/UltimateMarvel universe (which the show went with, depicting the Mad Thinker as a [[AgeLift teenaged]] [[GenderFlip girl]], instead of an adult man like the original). And then there's ComicBook/DoctorDoom and ComicBook/{{Magneto}}, who both show up in Season 2 (Magneto's appearance, in fairness, also features Professor X and Jean Grey, both of whom were from the X-Men).
193* The “Armor Wars” two-parter in ''WesternAnimation/IronManTheAnimatedSeries'' sees the title character hunting down various armored characters from across the Marvel Universe, including the Beetle (originally a Human Torch villain and best known for fighting Spider-Man) and Stilt-Man (an enemy of Daredevil).
194* ''WesternAnimation/MarvelsSpiderMan'' has two examples:
195** The Blizzard used for this series, Randall Macklin, is a one shot enemy of Iron Man, who does not appear in this episode, and his origin involves Harry and Peter's invention, likely in reference to Blizzard sometimes facing Spider-Man.
196** Absorbing Man is normally a foe of the Hulk and Thor, the former having appeared in only the Halloween episode, and the latter only appearing in later seasons.
197* ''WesternAnimation/TheMarvelSuperHeroes'' had an episode of the ''Sub-Mariner'' segment feature Doctor Doom as its villain. Doom's usual enemies the Fantastic Four couldn't appear because of rights issues (having already been used by Creator/HannaBarbera for ''WesternAnimation/TheFantasticFour1967''), so they were replaced by the original roster of the X-Men, albeit referred to as the Allies for Peace.
198* The true villain of the first season of ''WesternAnimation/{{MODOK|2021}}'' is ultimately revealed to be [[spoiler:Hexus the Living Corporation, who originated in Creator/GrantMorrison's ''Marvel Boy'' limited series]].
199* ''WesternAnimation/MoonGirlAndDevilDinosaur2023'':
200** Allison Dillon / Aftershock serves as the main villain Lunella and Devil face in the pilot episode. The character was originally created as a villain for ComicBook/SpiderGirl.
201** The Beyonder, a universe-wide threat primarily known for his association with heroes like Spider-Man and the Avengers, serves as a recurring character throughout the season despite having no real connection to Lunella in the comics.
202** The episode "Today, I Am a Woman" sees Lunella clash with Odessa Drake, a rival and ex-lover of Characters/{{Black Cat|Marvel Comics}}.
203* ComicBook/DoctorDoom was featured as a villain in ''WesternAnimation/SpiderMan1981'' and its related series ''WesternAnimation/SpiderManAndHisAmazingFriends'', neither of which acknowledged his usual enemies the Fantastic Four. Spider-Man considered him his ArchEnemy instead of Doctor Octopus or Green Goblin in those series.
204* ''WesternAnimation/SpiderManUnlimited'' had Spidey going up against the High Evolutionary, normally a cosmic Marvel villain (though he has ties to the X-Men; he was once a colleague of Spidey's foe Jackal in the comics, but that was about it for pre-existing connections).
205* The ''WesternAnimation/SpiderWoman'' episode "Realm of Darkness" had Spider-Woman fight Dormammu, who was traditionally an enemy of ComicBook/DoctorStrange.
206* Taken to the extreme in ''WesternAnimation/UltimateSpiderMan2012'', as part of the show's apparent attempt to be as different as possible to the traditional Spider-Man formula. So far, the show has largely avoided classic Spider-Man antagonists, the only ones showing up after more than ''twenty'' episodes being ComicBook/{{Venom}} ([[spoiler:with Harry Osborn as the host instead of Eddie Brock, though the symbiote later goes to Flash Thompson and turn him into Agent Venom as it does in the comics]]), ComicBook/DoctorOctopus, ComicBook/NormanOsborn (who doesn't become the Green Goblin until the ''season finale'') and Sandman. The other episodes involve either crossover episodes with other heroes involving villains from the guest-star's rogue gallery (Living Laser for ComicBook/IronMan, Loki for [[ComicBook/TheMightyThor Thor]], Zzzax for [[ComicBook/TheIncredibleHulk the Hulk]], Mesmero and ComicBook/{{Sabretooth}} for ComicBook/{{Wolverine}}) or villains from other Rogues Galleries who are treated like they were Spider-Man's regular villains (Doctor Doom and the Frightful Four, whom are Fantastic Four villains, Batroc the Leaper, whom is a Captain America villain, ComicBook/{{Taskmaster}}, who debuted as an Avengers villain, Whirlwind, originally a foe of Ant-Man, the ComicBook/{{Juggernaut|MarvelComics}} (though justified in that there was one notable comic story where Spider-Man did fight Juggernaut)...) As an added twist, some of Spider-Man's foes are now tied to other heroes, such as Kraven being the one who killed ComicBook/WhiteTiger's father, and the Scorpion being from the same mythical city as ComicBook/IronFist. Even though the show did eventually bring in more Spider-Man rogues and storylines, the aforementioned Taskmaster becomes TheHeavy in the first half of season 3, where he recruits potential new SHIELD heroes [[spoiler:to spring Green Goblin from prison, leading to Goblin's travels across the Spider-Verse]], and in season 4, ComicBook/{{HYDRA}} and its leader Arnim Zola, both foes of Captain America and SHIELD (the latter being the mentors to Spider-Man and other heroes) begin to back the Sinister Six, and Crossbones, another foe of Cap and SHIELD, [[spoiler:is selected by HYDRA to replace Dr. Curt Connors as the Lizard when Spider-Man successfully cures Connors for good]].
207[[/folder]]

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