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9* The [[ScrewedByTheNetwork poor scheduling by networks]] of ''WesternAnimation/TheAdventuresOfTeddyRuxpin'' led to the death of any new stories being produced for the ''Teddy Ruxpin'' franchise, and also had a hand in bankrupting series creator Worlds of Wonder.
10* The failure of ''WesternAnimation/TheAvengersUnitedTheyStand'' was the final nail in the coffin of the (loosely defined, but still there) [[Creator/MarvelAnimation Marvel animated universe]] that aired on Creator/FoxKids throughout the '90s. All subsequent Marvel cartoons have taken place in other continuities and aired on other networks. It wouldn't be until ''[[WesternAnimation/UltimateSpiderMan2012 Ultimate Spider-Man]]'' that Marvel would nurture the idea of a shared animated universe again[[note]]Although ''WesternAnimation/TheAvengersEarthsMightiestHeroes'' is said to take place in the same universe as ''WesternAnimation/WolverineAndTheXMen2009'' due to Creator/ChristopherYost's involvement in both series[[/note]].
11* ''WesternAnimation/Ben10Omniverse'': While the ratings for it were an improvement over ''[[WesternAnimation/Ben10UltimateAlien Ultimate Alien]]'', the show's DenserAndWackier tone, [[BrokenBase questionable story decisions]] and [[TookALevelInDumbass dumbing down of the main character]] (all of which were intended to [[PanderingToTheBase appease fans of the first series]]) resulted in a less than stellar reception from the fanbase. Adding to the toy sales not doing very well, Cartoon Network chose to make the next series [[WesternAnimation/Ben102016 a continuity reboot]] that Creator/ManOfActionStudios, the original creators of the franchise, returned for. While ''Omniverse'' didn't kill the franchise itself, it did end up killing the original continuity of ''Ben 10''.
12* The failure of ''WesternAnimation/BewareTheBatman'' (not helped by [[InvisibleAdvertising lack of advertising]] and [[ScrewedByTheNetwork few reruns]]), along with the success of ''WesternAnimation/TeenTitansGo'', led to the death of ''WesternAnimation/DCNation'' as well as action-adventure series on Cartoon Network (at least, those without heavy comedy elements) in general for the next three years. Regarding family friendly DC animated shows, the creators and producers started relying more on DVD and digital services, along with sites like Website/YouTube, hence the longevity of shows like ''WesternAnimation/DCSuperHeroGirls''. As a result, there barely were any other new family-friendly DC cartoons other than ''TTG'' on TV for a few years, aside from ''WesternAnimation/JusticeLeagueAction'', which was [[InvisibleAdvertising barely advertised]] and [[ScrewedByTheNetwork ended up being screwed]], and a cartoon adaptation of DC Super Hero Girls helmed by Lauren Faust and closer to her earlier DC Super Best Friends Forever shorts which aired on DC Nation. Even then, the latter show was also [[InvisibleAdvertising barely advertised]], [[ScrewedByTheNetwork is only reran on]] Creator/{{Boomerang}} (which has less coverage than Cartoon Network) and has new episodes shoved into [[FridayNightDeathSlot awkward Sunday afternoon slots]] (which, granted, is better than what JLA got with its Saturday Morning death slot). Creator/DCUniverse, meanwhile, leaned in the other direction for darker animated series, giving the UnCancelled treatment to ''WesternAnimation/YoungJustice2010'' as being a bit more violent than originally, as well as including ''WesternAnimation/HarleyQuinn2019'' as an adult cartoon.
13** ''Beware the Batman'' also stopped other animated series specifically focused on Batman from being made for several years, in spite of ''Justice League Action'', ''Young Justice'', and ''Harley Quinn'' featuring him in prominent roles, until the announcement of ''Batman: Caped Crusader''.
14* ''WesternAnimation/BluesClues'' suffered from two major moments that are considered to have killed the show. The first was Steve Burns leaving in 2002. Both parents and kids found themselves less invested in new host Donovan Patton (AKA Joe), who would admit years later that Steve was clearly the superior host. However, the show managed to pull on for another two years with Patton as host. The second, much clearer one, was the SpinOff, ''Series/BluesRoom'', in 2004. Many inexplicable changes were made for the spin-off: specifically, [[ChuckCunninghamSyndrome the non-appearance of many characters from the main show]], [[SuddenlySpeaking Blue now being able to speak]], the [[ArtShift change to puppetry]] as well as the revamp of the notebook[[note]]instead of items being drawn into it, items now magically appear in the notebook, were sentient, and ''sang a little ditty'' - which many fans found to be boring dry, but also annoying[[/note]]. This was because it was likely made as an attempt to compete with ''Series/SesameStreet'' and its ''Series/ElmosWorld'' segments.[[note]]The popularity of the latter with kids and the former's presence on the popular Creator/{{Noggin}} channel and Creator/PBSKids led to a boost in ratings for new episodes. The fact that Sesame took a page out of Blue's Clues' book with the ''Journey to Ernie'' segments didn't help.[[/note]] It didn’t help that, just like ''Elmo's World'', episodes of ''Clues'' [[EveryEpisodeEnding now ended with a Room segment]], which likely caused even more people to tune out. Production of both shows ceased in 2006 and 2007, respectively. However, the show still remained a staple of the Nick Jr. brand over the next ten years thanks to on-demand and streaming services in the US and Europe, and DVD sales remained strong in all markets, paving the way for [[WesternAnimation/BluesCluesAndYou a reboot]] which premiered in late 2019.
15* ''WesternAnimation/TheBoondocks'': When series creator Aaron [=McGruder=] left after Season 3 due to a contractual dispute with Creator/SonyPicturesTelevision and Creator/AdultSwim, Season 4 was developed without him. Due to [[BrokenBase heavy fan backlash against the final season]], ''The Boondocks'' was cancelled in 2014, and the franchise's future was left uncertain. Though in 2019, Sony Pictures announced that the animated series would be revived on Creator/HBOMax in the near future (this time with [=McGruder=] returning as the showrunner), albeit as a ContinuityReboot instead of a straightforward continuation. However, the reboot was eventually scrapped while barely in development, still leaving ''The Boondocks'' as a dead franchise.
16* ''Series/CodeLyokoEvolution'' was this for Moonscoop's ''WesternAnimation/CodeLyoko'' franchise. Fans not only lambasted the show's shift to live action but also the wooden performances of its actors and reacted strongly to the new character Laura Gauthier. The show's writing was also heavily criticized, as all of Moonscoop's original ideas and scripts were scrapped by the new staff, leading to Moonscoop [[DisownedAdaptation disowning the new show]]. All of this led to ''Evolution'' [[ShortRunners lasting only 1 season of 26 episodes]], [[NoDubForYou with only one episode receiving an English dub]]. With Moonscoop Entertainment filing for bankruptcy a year after the show’s conclusion and its reorganization into Splash Entertainment (now infamously known for ''WesternAnimation/NormOfTheNorth'' among others) making any follow up unlikely, ''Evolution'' has likely ended the franchise for the foreseeable future.
17* The ''WesternAnimation/{{Cloudy with a Chance of Meatballs|2017}}'' animated series is what killed any future for the ''Cloudy'' franchise. What didn't help was [[InvisibleAdvertising lack of merchandise and proper marketing]]. However, the show did maintain a small (albeit mostly-[[WatchItForTheMeme ironic]]) cult following years later.
18* [[AdoredByTheNetwork After being loved by Nick Jr. for fourteen years]], ''WesternAnimation/DoraTheExplorer'''s third spin-off, ''WesternAnimation/DoraAndFriendsIntoTheCity'' was considered as a failure by fans (especially those who grew up watching the show), which caused the whole show to suddenly get overpassed by its new flagship franchise, ''WesternAnimation/PAWPatrol'', due to high ratings and toy sales. It didn't help that by this point, Dora's ratings were being surpassed by [[WesternAnimation/DocMcStuffins most]] [[WesternAnimation/SofiaTheFirst of]] [[WesternAnimation/JakeAndTheNeverlandPirates the]] [[Creator/DisneyChannel Disney Junior]] lineup. Nick decided to hide anything Dora-related into early morning time slots, in shame of killing one of their most lucrative franchises. However, it was still popular enough on streaming services to get a [[Film/DoraAndTheLostCityOfGold live-action film]] and a reboot series for Creator/ParamountPlus.
19* Ever wondered why you don't hear much about ''WesternAnimation/FelixTheCat'' anymore outside of merchandising or that 2004 direct-to-video film? You can pin the blame on the failure of 1988's ''WesternAnimation/FelixTheCatTheMovie''. FillingTheSilence, poor animation and lip-syncing, a RandomEventsPlot (and a poorly executed one at that) and numerous {{plot hole}}s can make this movie painful to watch for even the most avid Felix fan. TheNineties cartoon ''WesternAnimation/TheTwistedTalesOfFelixTheCat'' attempted to revive the franchise, but poor ratings for the first season, prompting an unsuccessful {{retool}} in the second season ([[GoneHorriblyWrong which did even worse in ratings]]), quickly brought Felix to an early grave yet again. Don Oriolo, who formerly held the rights to the character and related intellectual property, then tried to bring Felix to the CGI world in the form of another cartoon, but that went nowhere and the rights to Felix and related properties were eventually passed on to Creator/DreamWorksAnimation and Creator/{{Universal}}. Neither studio has a concrete plan to resurrect Felix at the moment besides licensing merchandise, and the character's 100th anniversary in 2019 went by without even so much as a Google Doodle. It lasted until 2023 when Felix got a graphic novel released.
20** Even before those was the failure of the early 30's sound cartoons; Pat Sullivan made little effort to upgrade the Felix cartoons to sound (not helped by his private life being in shambles due to his wife's alleged suicide and his heavy alcoholism) and when he did, they were rushed, sloppy, and far behind the times, resulting in the Felix cartoon series getting forgotten by the far more popular WesternAnimation/MickeyMouse shorts--Sullivan's subsequent death put the final nail in the coffin for his animation studio. An attempt to revive the cartoons was done in the mid-1930s by Creator/VanBeurenStudios; while the cartoons were seemingly well received despite having little in common with the character's previous appearances, when RKO negated Van Beuren's contract in favor of distributing Disney, it caused Van Beuren to go belly-up, thus sending Felix to an early grave yet again, [[StillbornFranchise after only three color shorts]]. What caused the franchise to not fully die out, is that despite the cartoons being put on ice, Felix still ran in newspaper and magazine comics for quite a long time.
21* After writer/story editor Michael Reaves wrapped up the second season of ''WesternAnimation/{{Gargoyles}}'', Disney wanted more, even though the story had concluded. So a third season called ''Gargoyles: The Goliath Chronicles'' was created -- one that didn't involve Reaves or any of the other show's previous core writers. (Producer Creator/GregWeisman was still around, but after cashing his checks, quickly disowned his involvement.) ''Gargoyles: The Goliath Chronicles'' was not well-received, and pretty much sank the franchise. Weisman later wrote a comic series to replace the third season, but it didn't sell well enough to keep up once [[ScrewedByTheNetwork Disney hiked up the licensing fee]]. Greg Weisman then wrote another comic series for the franchise later, with the ''Gargoyles'' video game subsequently receiving a VideoGameRemake in 2023, showing the franchise may not entirely be done.
22* The negative reception of the AnimatedAdaptation of ''Series/HenryDanger'', ''WesternAnimation/TheAdventuresOfKidDanger'', alongside creator Creator/DanSchneider's departure the same year it premiered, pretty much killed off Schneider's long-running namesake ''Schneider's Bakery'' series of sitcoms (''Series/AllThat'' reboot notwithstanding).
23* ''WesternAnimation/HeyArnold'':
24** Despite making five times its budget, ''WesternAnimation/HeyArnoldTheMovie'' was still considered a BoxOfficeBomb (since the studio spent another $13 million on marketing the film) and was critically panned. This led to the cancellation of ''WesternAnimation/HeyArnoldTheJungleMovie'' (until it was {{Uncanceled}} 15 years later) and likely why the remaining episodes of ''Hey Arnold!'' were aired sporadically until the final one aired in 2004, three years after production of the series ended. However, with Nickelodeon rebooting most of its classic Nicktoons in 2015, ''The Jungle Movie'' was SavedFromDevelopmentHell and released in 2017, with the network suggesting that a revival could be at hand.
25** While ''The Jungle Movie'' was critically acclaimed, it floundered in the ratings against ''Trolls Holiday''. This not only meant that a revival was out of the question, but it also led to the cancellation of the ''entire'' Nicktoon reboot plans (by this point there were rumors about a "mega-crossover" movie and even a SharedUniverse), with only the ''WesternAnimation/RockosModernLife'' and ''WesternAnimation/InvaderZim'' specials being produced (both of which were eventually released on {{Creator/Netflix}} instead of airing on Nick proper) and ''WesternAnimation/{{Rugrats}}'' getting a CG/live action film and [[WesternAnimation/Rugrats2021 a revival]], although the former was later axed after being removed from Creator/{{Paramount}}'s schedule.
26* The ''WesternAnimation/HollyHobbieAndFriends'' direct-to-DVD series has an interesting case of this when the producers of the show decided to change several aspects of the franchise from the fifth DVD on. Said DVD, ''Fabulous Fashion Show'', was so badly reviewed across the board, with an overall 1.3/5 on Amazon with 18 reviews, compared to 4+ star averages for the others, that it all but killed the franchise. The subsequent DVD, ''Marvelous Makeover'', rebounded to 3.3 stars, but the various changes that had been made to the series, such as moving to 22 minute stories and [[TheOtherDarrin replacing most of the voices]], were still generally poorly regarded. Making things worse was the shoddy voice replacement job- the new cast sounds nothing like the old one, and while they opted to use a NonSingingVoice for the titular character, the singing voice and speaking voice wasn't even matched either. Aside from that, the characterizations were all botched and the characters were passing the IdiotBall around. The show's final picture book release was seen a bit later in 2008, and afterwards, production on all media was discontinued entirely until 2017, where the franchise was rebooted into a live-action series.
27* Universal and Hanna-Barbera released ''WesternAnimation/JetsonsTheMovie'' in 1990, complete with admittedly impressive at the time CGI, a GreenAesop that was essentially a rewrite of an old episode of ''Star Trek'', and reuniting nearly all of the surviving original cast members[[note]] Daws Butler, the voice of Elroy Jetson, had died in 1988; the role was re-cast with a young Patric Zimmerman, nearly a decade before he voiced Revolver Ocelot in the ''VideoGame/MetalGearSolid'' series.[[/note]] save for Judy Jetson being voiced not by Creator/JanetWaldo but by '80s pop starlet Tiffany thanks to ExecutiveMeddling. The film also marked the last performance ever of noted voice artist Creator/MelBlanc (Mr. Spacely), who was still recording while in the hospital (as he had years before then) and died before the film was completed, as well as George O'Hanlon ([[TheDanza George]]), who by that point had to have the lines read and acted to him before recording, who also passed away before he could quite finish the film (with George supposedly dying of a stroke ''in the recording booth''). Both Blanc and O'Hanlon's remaining lines had to be completed by Creator/JeffBergman. Penny Singleton did not die during production like Blanc and O'Hanlon, but the movie remained her last acting role until her death thirteen years later. Coming on the heels of the 1980s ''[[WesternAnimation/TheJetsons Jetsons]]'' revival (the new syndicated episodes and two TV movies), this film's disappointing box office and harsh critical reviews were apparently enough to send the franchise back into hibernation. It would stay there (despite rumors of a potential live-action film occasionally floating about, [[DevelopmentHell which ultimately has never been made]]) until [[WesternAnimation/TheJetsonsAndWWERoboWrestlemania a direct-to-video film crossing over with]] Wrestling/{{WWE}} was released in 2017, which received mixed reception.
28* The cancellation of Creator/CartoonNetwork's ''WesternAnimation/{{Mad}}'', combined with that of the ''Series/{{MADtv|1995}}'' {{revival}} on Creator/TheCW, dashed any future attempts to to adapt the satirical ''Magazine/{{Mad}}'' Magazine to any form of other media. The former had a successful four-season run, but the RippedFromTheHeadlines-nature of its comedy meant it was doomed to become an UnintentionalPeriodPiece whose reruns quickly ceased to entertain the network's target demographic. Meanwhile, the revival series only managed eight episodes before being scrapped. With the magazine suffering from MagazineDecay due to being switched to a nearly all-reprint magazine in late 2019 as a result of the AT&T/Time Warner merger, even the future of the magazine itself looks uncertain.
29* The end of the ''WesternAnimation/{{Madeline}}'' cartoon franchise tends to be blamed by fans on the 2002 feature-length TV movie, ''My Fair Madeline'', which was heavily criticized for its unpleasant plot involving Madeline being put through an unfair TraumaCongaLine after being blamed for causing a mess at an art museum, with not even Miss Clavell believing her when Madeline explains she was trying to expose an art theft, to the point that she is sent away from the old house covered in vines and away from her friends. A final feature-length production, ''Madeline in Tahiti'', was made in 2005, but was never released on DVD in the US, only finally getting a digital release in 2017, and with that the franchise has likely ended for good.
30* While a planned sequel got scrapped, Creator/DreamWorksAnimation had still made a few attempts to turn ''WesternAnimation/MonstersVsAliens'' into a multimedia franchise early on, with the movie getting animated shorts (''Mutant Pumpkins from Outer Space'', ''Night of the Living Carrots'') and crossover video games (''VideoGame/MadagascarKartz'', ''VideoGame/DreamWorksSuperStarKartz''), but the poor reception and failure of the short-lived ''WesternAnimation/MonstersVsAliens2013'' series ultimately killed any further projects the studio may have planned, and the series itself hasn't seen any major acknowledgement beyond the occasional multi-franchise crossover like ''[=DreamWorks=] Universe of Legends''. As of the present day, ''Monsters vs. Aliens'' is the only [=DreamWorks=] franchise to receive a show, but not during DWATV’s streaming era that began in 2013.
31* The commercial failure of ''WesternAnimation/TheMrMenShow'' when it aired on Creator/CartoonNetwork in the US, including its [[InvisibleAdvertising scant promotion]], its awkward timeslot and a DenserAndWackier tone that bore little to no resemblance to the source material (some characters even being InNameOnly interpretations of their namesakes, including two existing characters that were [[GenderBender gender-swapped]]), essentially killed off further attempts at adapting the ''Literature/MrMen'' franchise to television, although the books themselves are still going strong to this day. All Mr. Men animations released since have been television commercials or [[WebAnimation short Internet videos]], which have more or less kept the art style and designs of the original books. However in 2021, it was announced a new series is being produced.
32* The critical failure of ''WesternAnimation/PinkyElmyraAndTheBrain'' was this not just to ''WesternAnimation/PinkyAndTheBrain'', but to ''WesternAnimation/TinyToonAdventures'' and ''WesternAnimation/{{Animaniacs}}'' as a whole. The show was created as a result of ExecutiveMeddling, which was even pointed out in its theme song ("''It's what the network wants, why bother to complain?''"). In 2020, Pinky and the Brain would make a triumphant return in the Creator/{{Hulu}} exclusive ''WesternAnimation/Animaniacs2020'', along with the Warner Siblings themselves, the first episode of which [[CanonDiscontinuity retconned]] ''[[CanonDiscontinuity PE&tB]]'' [[CanonDiscontinuity from existence]]. On October 28, 2020, a ''Tiny Toon Adventures'' reboot called ''WesternAnimation/TinyToonsLooniversity'' was announced for Creator/HBOMax and Creator/CartoonNetwork, and on November 1, 2020, Creator/CreeSummer stated that [[PutOnABus Elmyra would be dropped from the reboot]]. However, later released promotional artwork for the reboot revealed that Elmyra would be returning after all. ''Looniversity'' premiered on MAX on September 8, 2023.
33* The critical and ratings bomb that was ''WesternAnimation/PlanetSheen'' killed off all interest in the ''[[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Jimmy Neutron]]'' franchise for much of the 2010's, despite the original show continuing to enjoy sporadic reruns on sister channel Creator/{{Nicktoons}} to this very day. Fans of the original series were not pleased with how the show [[ChuckCunninghamSyndrome removed Jimmy entirely]] and focused entirely on his PluckyComicRelief friend Sheen Estevez, whom most people believed couldn't sustain a series on his own the same way Jimmy did. Not helping matters was the fact that one of the studios behind the show, DNA Productions, went bankrupt in 2008 due to the failure of their 2006 feature-length film ''WesternAnimation/TheAntBully''. It wouldn't be until the 2020's that Creator/{{Nickelodeon}} would start to acknowledge the show more frequently again, with Jimmy's father Hugh appearing as a playable character in the fighting game ''VideoGame/NickelodeonAllStarBrawl'' (even though that was mostly because fans jokingly requested for him), with Jimmy appearing in its sequel, and Jimmy and his rival Cindy Vortex appearing as playable characters in the third ''VideoGame/NickelodeonKartRacers'' game, among other appearances.
34* The box office failure of ''WesternAnimation/ThePowerpuffGirlsMovie'' led to the scrapping of all plans for future theatrical films based on Creator/CartoonNetwork properties, with the channel's film output for the rest of the 2000's being exclusively made-for-TV. It would take sixteen years, with the release of ''WesternAnimation/TeenTitansGoToTheMovies'', for another Cartoon Network series to see a theatrical wide-release - and even then, [[WesternAnimation/TeenTitansGo the show it's based on]] is a Creator/DCComics/Creator/WarnerBros property. While that film performed far better than ''Powerpuff Girls'', it just wasn’t the box office smash hit Warner Bros. expected (not helped by a [[ScrewedByTheNetwork surprisingly small marketing campaign for the movie]]), grossing $52 million against a $10 million budget;[[note]]Beast Boy's voice actor Greg Cipes is on record for mentioning $250 million as a target number, but it isn't clear how much of that was just wishful thinking on his part.[[/note]]any plans for an actual ''WesternAnimation/TeenTitans2003'' continuation are now in doubt. Following Cartoon Network shows would continue to see television premieres or direct-to-video or streaming releases for their long-form adventures, including the second TTG film, ''WesternAnimation/TeenTitansGoVsTeenTitans''.
35* The abrupt cancellation of ''WesternAnimation/RenAndStimpyAdultPartyCartoon'' put the series on the kibosh for well over a decade. The lackluster sales of the DVD sets didn't help this. It also helped put an early end to the entirety of the then-new Creator/SpikeTV's animation block, thus taking down ''WesternAnimation/{{Stripperella}}'' (which was also hampered by a lawsuit) and ''WesternAnimation/GaryTheRat'' along with it, although the former was at least popular enough once it hit DVD, only to see more negative reception pile on over the years thanks to a lawsuit filed against the show's creator Creator/StanLee. It would be 17 years before Viacom would try again with reviving or rebooting Ren and Stimpy, when a revival was announced for Creator/ComedyCentral in August.
36* The ''WesternAnimation/{{Rugrats}}: Tales From the Crib'' series was a [[DirectToVideo direct-to-DVD]] series of FracturedFairyTale-esque movies, which attempted to make the original series popular again after it ended. However, there were only two entries in the series; "Snow White" and "Three Jacks and a Beanstalk", as the latter failed to impress. This also forced the "[[WesternAnimation/RugratsPreSchoolDaze Pre-School Daze]]" spin-off (which had its episodes included as bonuses on the [=DVDs=]) to end at only four episodes. The ''Rugrats'' franchise would later be revived in 2017 through a comic book, and a live-action/CGI hybrid film was announced in 2018, [[https://deadline.com/2019/11/rugrats-movie-pulled-wwe-rumble-release-date-titles-spongebob-movie-sponge-on-the-run-1202784527/ but was later pulled]], though [[WesternAnimation/Rugrats2021 a full CGI reboot of the series]] eventually premiered on Creator/ParamountPlus on May 20th, 2021.
37* The ratings bomb that was ''WesternAnimation/SonicUnderground'' led to [[Creator/DiCEntertainment [=DiC=]]] losing the license to produce ''Franchise/SonicTheHedgehog'' television series. The West was left without an animated ''Sonic'' series for 15 years (barring the Japanese-made anime ''Anime/SonicX'') until ''WesternAnimation/SonicBoom'' in 2014. Unlike the previous series, however, ''Sonic Boom'' was co-produced by Sega in-house. Sadly, even this wasn’t enough, as [[VideoGame/SonicBoom the tie-in video game]] was a notorious failure that casted one of many dark clouds on the already struggling franchise, leading to Creator/CartoonNetwork and Boomerang [[ScrewedByTheNetwork neglecting it, with Sega joining the neglect later on]]. After the series [[https://comicbook.com/gaming/2019/10/16/sonic-mania-adventures-animated-shorts-yukio-kusumoto-interview/ ended its run]], later Sonic animations were made in short-form, released on the Internet, silent, and largely done in-house by Sega’s artists. Sega later gave Sonic another chance with [[Recap/OKKOLetsBeHeroesS3E10LetsMeetSonic a crossover]] with Cartoon Network’s own ''WesternAnimation/OKKOLetsBeHeroes'', but even then that show too was [[{{Irony}} screwed by CN,]] with the show’s creator announcing the cancellation shortly after the episode aired. While Sega's Director of Animation Yukio Kusumoto [[https://comicbook.com/gaming/2019/12/25/new-sonic-tv-show-sega-possibility/ believes the world is ready for a new Sonic TV show,]] only time will tell if the Blue Blur will return to grace our television screens, seeing that Sega was more focused on [[Film/SonicTheHedgehog2020 the film adaptation]] at the time. Eventually, a new ''Sonic'' cartoon, ''WesternAnimation/SonicPrime'', was announced for Creator/{{Netflix}}, with the involvement of Sega, Creator/WildBrain (the current owner of [=DiC=]'s back catalog), and Creator/ManOfActionStudios.
38* The ratings failure of ''WesternAnimation/SuperMarioWorld'', along with the cancellation of ''WesternAnimation/CaptainNTheGameMaster'' and the closure of NBC's Saturday morning cartoon block, killed off any further attempts to keep the Franchise/SuperMarioBros on television. Most of this is due to the budget cuts NBC made which resulted in the animation quality being worse than that of the previous two ''Mario'' cartoons, Toad being written out completely and [[ReplacementScrappy being replaced with the less memorable Oogtar]], and the plots being weaker and running more on nonsensical logic than those of the previous two ''Mario'' cartoons. The only subsequent ''Super Mario Bros''.-related television series made since then was ''The Super Mario Challenge'', a live-action game show from the United Kingdom that aired and ended around the same time as ''World'' (although one could also count the ''WesternAnimation/DonkeyKongCountry'' CGI cartoon, if they considered the ''Franchise/DonkeyKong'' franchise to be part of the ''Mario'' franchise). However, ''Super Mario World'' may be one of the rarest examples of a cartoon being [[VindicatedByHistory Vindicated by]] YouTubePoop, having been a staple of said videos for years.
39* The failed 1999 pilot ''WesternAnimation/{{Curbside}}'' was the final nail in the coffin for the Creator/{{Terrytoons}} characters. Creator/{{Nickelodeon}} didn't pick it up and as a result, Creator/{{Viacom}} lost whatever interest they had left in the franchise. This was because the pilot was produced by a crew that, according to Jerry Beck (who ''originally'' headed the project), [[CreatorsApathy didn't know or care about anything involving the original Terrytoons shorts]]. There now seems to be an unspoken "No Terrytoons Projects" rule at Viacom because Beck tried to make a Sidney the Elephant cartoon for ''WesternAnimation/RandomCartoons'', only for them to [[ExecutiveMeddling force him]] to replace Sidney with another character[[note]]The short was completed under the title ''Hornswiggle''[[/note]].
40* The overall negative reception to ''WesternAnimation/TomAndJerryWillyWonkaAndTheChocolateFactory'' managed to pause the ''WesternAnimation/TomAndJerryDirectToVideoFilmSeries'' for 5 years, while Creator/WarnerBros turned its attention to [[SavedFromDevelopmentHell producing the long-stalled]] [[Film/TomAndJerry2021 live-action/animated film]] instead. It also caused the Creator/RoaldDahl Estate to revoke Warner Bros.' film rights to ''Literature/CharlieAndTheChocolateFactory'' ([[AshCanCopy the latter having commissioned the movie just to keep the film rights)]] and instead handed it over to Creator/{{Netflix}}, along with all the other stories he created, including [[Literature/CharlieAndTheGreatGlassElevator its sequel]] in which Dahl himself wrote in his will that [[NoAdaptationsAllowed it may never be adapted in any form.]]
41* ''Franchise/{{Transformers}}'':
42** After ''WesternAnimation/BeastMachines'' there was supposed to be a sequel series (complete with prototype toys made) called ''[[Toys/TransformersTranstech Transtech]]'' and it would have continued even further into the series timeline. While ''Beast Machines'' still had solid ratings, the reception was mediocre and the toys themselves were subpar and didn't sell. Recognizing they had taken the Beast era franchise as far as it could go, Hasbro scrapped ''Transtech'' and imported ''Anime/TransformersRobotsInDisguise'' while they worked on a complete ContinuityReboot with ''Anime/TransformersArmada.'' This did have the interesting effect of splitting ''Franchise/{{Transformers}}'' into many {{Alternate Universe}}s rather than just [[AlternateContinuity Alternate Continuities]].
43** The franchise in Japan as a whole experienced multiple franchise killers over the years:
44*** By 1990 the popularity of the franchise was at its lowest, with ''[[Manga/TransformersZone Zone]]'' marking the final animated entry in the Japanese G1 franchise (it was so bad the series was represented by a single OVA instead of a full season like earlier entries), mirroring what happened to the G1 in the west during the 90s, with ''Operation Combination'' as the last toyline in 1992, followed by a 3 years hiatus until Generation 2 (which didn't do much better either).
45*** After ''Beast Wars'' renewed interest in the brand, ''Anime/BeastWarsII'' and ''Anime/BeastWarsNeo'' were created to buy time in order to complete the dub of the second and third seasons of ''Beast Wars''. Unfortunately, the ''Neo'' toyline suffered from fiddly designs, weird beast modes, and overcomplicated transformations that weren't at all popular with kids, which led to it mostly crashing and burning. By the time ''Beast Wars Metals'' (Re-brand of the 2nd and 3rd season of the show) aired, the damage was done and its toyline was a flop that lasted barely ''four'' months in retail (for context, a ''Transformers'' toyline in Japan usually lasts a full year at least). This motivated Takara to do a Soft Reboot in the form of the ''Car Robots'' anime rather than import ''Beast Machines''... which would then be dubbed as ''Robots in Disguise''.
46*** And even THAT toyline flopped in retail (same problems as with ''Neo'', with the Transformers getting comparisons with origami due to how difficult they were to transform), resulting in its [[Anime/TransformersRobotsInDisguise show]] getting reduced to 39 episodes from a planned 52. Afterwards, Takara wouldn't release another ''Transformers'' toyline or show until [[Anime/TransformersArmada 2003]].
47*** The series got hit by another with the [[Anime/TransformersCybertron final entry in the Unicron trilogy]], whose toyline sales in Japan were abysmal, resulting in the toyline getting a unceremonial conclusion after barely 9 months instead of a full year as planned (the show at least managed to air all its 52 episodes... but the manga adaptation wasn't so lucky, getting an abrupt conclusion at 9 issues out of the 12 planned). What followed afterwards was a smaller toyline and fiction called ''Transformers: Kiss Players'' (aimed at 14 years and up), widely considered the worst entry ever released in Transformers by both sides of the Pacific due to the [[{{Squick}} rather disturbing]] plot element of the [[InterspeciesRomance Transformers kissing human girls]] to gain their powers and [[WhatDoYouMeanItsForKids being full of inappropriate sexual themes]]. The series wouldn't recover until the [[Film/TransformersFilmSeries Michael Bay movies]] made the franchise big again.
48*** ''WesternAnimation/TransformersPrime'', though reasonably successful in America, [[AmericansHateTingle dealt the franchise a blow in Japan that it still hasn't recovered from]]. The ratings were downright abysmal, to the point that it didn't even do well when new episodes aired against reruns of other shows--it was perceived as too dark for kids and too immature for teens, and the attempts to salvage this with a GagDub left it with an UncertainAudience. The toyline fared no better, due in part to an attempted pseudo-model kit design ethos that bounced off just about everyone involved. Even older fans who'd normally be into darker storytelling were apathetic at best. It was also incredibly expensive for partial brandholders Takara-Tomy, who were left holding a big chunk of the bag for a series that they didn't want. As a result, Takara simply [[UnfinishedDub stopped airing the series after season 2]], and scraped together ''Anime/TransformersGo'' as an attempt to arrest the failing toy sales. Though ''Go'' did improve things, it wasn't enough, and caused Takara to pivot to their original series, ultimately striking gold with ''Anime/ShinkansenHenkeiRoboShinkalion''. Since ''Prime'', the only ''Transformers'' series to air on Japanese television has been the dub of ''WesternAnimation/TransformersRobotsInDisguise'', which only aired on satellite and didn't finish its run, either, and by 2018, Takara had basically given up on selling their own ''Transformers'' line at retail (barring collector-oriented lines like ''Masterpiece''), only bothering to import Hasbro's offerings.
49* Season 8 of ''WesternAnimation/WinxClub'' ended up killing the original continuity. It was meant to be a ReTool that appealed to a younger audience. However, it instead ended up alienating both new and long time fans. In response, Creator/RainbowSrl has confirmed that the show will undergo a full on ContinuityReboot.
50* For Yogi Bear and the FunnyAnimals of Hanna-Barbera, ''WesternAnimation/YoYogi'' effectively killed off their careers for ''decades'', as well as killing off NBC's Saturday Morning cartoons. While Yogi and WesternAnimation/MagillaGorilla did appear in ''WesternAnimation/ScoobyDooInArabianNights'', that special served as Magilla's last animated appearance for nearly a quarter of a century. After an Easter special that didn't perform well either, Yogi's only further appearances were in a handful of obscure cartoons by John Kricfalusi, along with a [[Film/YogiBear live-action/CGI film]] in 2010 that was financially successful, but critically ravaged. In 2019, the Creator/HBOMax series ''WesternAnimation/{{Jellystone}}'' was announced; it would officially debut in 2021, a full ''three decades'' after the failure of ''Yo Yogi!''

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