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* Dr. Girlfriend from ''WesternAnimation/TheVentureBros'' has an exaggeratedly deep and masculine voice. It is eventually revealed that it is due to her being a chain smoker who regularly goes through three packs in one day.
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* Dr. Girlfriend from ''WesternAnimation/TheVentureBros'' has an exaggeratedly deep and masculine voice. It is eventually revealed that it is due to her being a chain smoker who regularly goes through three packs in one day.day, and has been smoking since 1989.
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** Krusty the Clown speaks with a very gruff, raspy voice. This can be attributed to, among other things, his nicotine addiction.
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*Goofy's original voice actor, Pinto Colvig, was also a heavy smoker who played Goofy almost to his death from lung cancer in 1967, so as time went by, his voice subtly changed to become less, well, goofy sounding. By the 1960's, Goofy has a lower and more worn sounding voice than he did in the 1930's.
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* Terrie Hall lost her larynx as a result of throat cancer caused by smoking, giving her a low, raspy voice. She would spend the rest of her life as an anti-tobacco activist, often appearing in PSA's the highlighted her voice to show the dangers of smoking.
