- Better by a Different Name: To some, the 2011 movie Contagion took the same idea and did it better.
- Critical Research Failure: In Boston, Robby asks the dying Jimbo to tell her how he might have been infected. A doctor of her (or any) caliber should know that's going to be difficult for him to do with a breathing tube down his throat.
- Crowning Moment of Funny: "Why are we flying so low?"
- And, of course, "With all due respect, fuck you. Sir."
- Anybody who's ever been in the military had a snicker at the scene where Dustin Hoffman's character basically browbeats a flight controller into changing his flight plan to Cedar Creek.
- Harsher in Hindsight: A real-life outbreak of the Ebola virus occurred in Zaire only a few months after the film was released.
- Nightmare Fuel: Averted, oddly enough. The symptoms of Motaba are basically painful flu-like symptoms followed by death, at least as far as we see. Ebola, on the other hand, is disturbingly horrifying, essentially rendering the body to a barely-living bag of blood as internal organs break down, bleed out, and essentially disintegrate until the host dies. Suffice to say, be glad they didn't show that.
- These were supposed to be the symptoms for Motaba too, but except for some bleeding from the eyes, they spare us the Squick of seeing it.
- One-Scene Wonder: The White House Chief of Staff (played by the uncredited J.T. Walsh) is in exactly one scene in which he gives a speech that deftly balances Reasonable Authority Figure and Realpolitik.