- All-Star Cast: Just look at all the names in the description!
- The Danza: Donald Sutherland playing Major General Donald "Donnie" McClintock.
- Hey, It's That Guy!: McDreamy plays the original owner of the monkey, and the first to die of the virus.
- J.T. Walsh, uncredited, plays the White House Chief of Staff that wants you to burn the faces of the residents of Cedar Creek into your memory.
- Hell, Kevin Spacey is in the movie and hardly anyone notices.
- Don't forget Betsy the monkey, aka Marcel.
- David Aceveda is one of Robby's co-workers at the CDC.