These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Awesome, but Impractical: The Dragon's Tooth Sword is easily the most powerful melee weapon...but is only obtained once you start primarily fighting the durable and explosive Templar armoured soldiers and the Illuminati elite troopers that release gas on death.
Boring Yet Practical: The baton strikes quickly, easily takes down enemies with the increased strength biomod, and can disable cameras and turrets without exploding them with the EMP Discharge biomod.
As par for a Deus Ex game, the humble pistol. Accurate, easy on ammo, and the unique variants have good firepower.
Disappointing Last Level: There is a certain point where all the plot threads have come together, after which the level design in the remaining couple of levels in the game becomes much less... "immersive", shall we say.
Game Breaker: The Spy Drone Biomod, at the highest level, can knock guards unconscious. Combine this with a repair bot, which constantly replenishes your bio-energy, and the Cloak biomod, to make you invisible, and you can secure an entire map from the safety of one room.
Electrostatic Discharge on level 3 turns bots and turrests on your side and disables cameras and laser beams, all just by hitting them with a melee weapon once.