These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Big Lipped Alligator Moment: A blue teddy bear, menaced by kissing aliens, operates a power boat and is unceremoniously thrown overboard by a giant lobster. Hell, half the bosses are like this; a cyborg wolf with an Arm Cannon riding a horse, anyone?
Goddamned Bats: Those bee-like enemies that you fight between boss battles. Better have the homing ready, as they come in swarms, shoot at you, then fly erratically and kamikaze you. The bomb-dropping alien birds also do get really annoying too.
Goddamned Boss: Some of the bosses may not be tough, but they are certainly annoying.
Several FA Qs and walkthroughs automatically assume you're playing this on an emulator and naturally assume you're going to save state anyway. But how to dodge Epsilon-1's bombing wave? If the initial strike is next to you, walk instead of teleport. If you teleport at the wrong time, you WILL eat the subsequent attack when you come to.