The Mexican Spanish dub is basically a reunion from many regulars from the dub of Sailor Moon. Ivy, just like in Japan, is also Sailor Venus and Zack is Seiya Kou from the same show as well. Carmen Sandiego (Rocio Garcel) is Luna and The Chief (Genaro Vasquez) was both Gurio Umino and Tuxedo Mask's first voice.
The original Ivy and Zack would later appear together as Sheena and Lloyd in the English dub of Tales of Symphonia. (Both also appeared in Avatar: The Last Airbender, but in completely unrelated roles, and only once in the same episode, "Bato of the Water Tribe.")
Technology Marches On: The Acme Detective Agency's entire database, Chief AI and all, can supposedly fit on a single standard CD. Granted, it was one of Carmen's own pieces of tech that pulled it off but still, she effectively stole Wikipedia and put it on a CD.
Unintentional Period Piece: It's really, REALLY Nineties. Easy way to tell? The World Trade center is still in background during the opening.