- Executive Meddling:
- CBS had the series made more domestic and much lighter in tone after the first season, insisting on a female character being added and Hawke's somewhat dark and troubled nature being toned down.
- Season 4 was made for the USA Network, which as a cable channel in 1987 and even after taking the series to Canada, could not afford to keep any of the original cast. Dominic Santini was killed off-screen since they couldn't afford even a few moments of Ernest Borgnine, and since they had the money for a few minutes of Jan-Michael Vincent they had String appear, but be critically wounded so he couldn't fly anymore.
- The Other Darrin: In the first series, St. John Hawke (when he appeared in flashbacks) was played by Christopher Connelly. When he became a main character following USA's re-launch of the series, he was played by Barry Van Dyke.
- Science Marches On: Archangel's comment to String that they'll never know if a Vietnamese-American boy in one episode is really St. John's son (and Stringfellow's nephew). DNA fingerprinting had just been invented in 1984 and was still new and not entirely well known or trusted, and DNA paternity testing wasn't really done much until the 1990's. Now that DNA testing has become a widespread thing that comment seems really ridiculous.