Please don't list this on a work's page as a trope. Examples can go on the work's YMMV tab.
Tear Jerker: The Blacklist
Luli's death in "Anslo Garrick", and the way Red desperately begs for their lives from both their killer and Harold (who can give Garrick what he wants by telling him the access code to the box Red has locked himself and Ressler in).
Red talking to Ressler when they were locked up in the former's cell, talking about how he just wanted to have a normal life with a family instead of being an underworld figure.
Red: Have you sailed across an ocean, Donald? On a sail boat surrounded by sea with no land in sight. Without the possibility of sighting land for days to come. To stand at the helm of your destiny. I want that one more time. I wanna be at the Piazza de Campo in Siena and feel the surge as 10 racehorses go thundering by. I want another meal in Paris at L'Ambroise on the Place de la Loge. I want another bottle of wine... and then another. I want the warmth of a woman in a cool set of sheets. One more night of jazz at the vanguard. I want to stand on summit and smoke cubans and feel the sun on my face for as long as I can. Walk on the wall again, climb the tower, ride the river, stare at the frescoes. I wanna sit in the garden and read one more good book. Most of all, I wanna sleep. I wanna sleep like I slept when I was a boy. Give me that... Just one more time.
Liz asking Red if he's her real father after Anslo Garrick was killed, despite the latter telling her that she can't believe everything he says because he's a known criminal.
The deterioration of Liz and Tom's relationship over the course of the series. With the revelation that he is really an assassin/spy, which confirms Red's accusations to Liz.