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Tear Jerker: House of Cards (US)
Fair warning. Spoilers any current seasons may be unmarked. As Netflix releases the episodes for an entire season at one time, material from all episodes beginning to end is fair game.
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Russo's attempt at sobriety and faithfulness, inspired by Francis, being undone slowly during a conversation with Rachel, culminating in him giving in on both booze and lust after finally getting his life together and getting things right.
Russo's daughter telling him she and her brother don't want to talk to him when he calls her while drunk.
Russo's children asking whether Christina is coming back because they liked her.
Underwood's words to a screaming, deranged homeless man trying to get into the congressional office building: "Nobody can hear you. Nobody cares about you. Nothing will come of this." It's the look of utter shock and despair the homeless man gives when Underwood's words sink in.
Claire's panic attack after meeting her college rapist for the first time in several decades.
And Frank's reaction to this, and their conversation later that night...basically everything regarding that situation.
Everything that happens to Freddy, through absolutely no fault of his own, after getting caught up in the war between Frank and Raymond Tusk. After business picks up enormously after a flattering human interest article is written about him running the Vice President's favorite restaurant over the past twenty years, he blips onto Tusk's radar as a connection to Frank and therefore a target. He releases information to the media about Freddy's criminal past when he was a young man and causes a potential restaurant franchise investor to back out of giving Freddy a huge payday. At the same time, Freddy's estranged son, with whom Freddy had just begun to reconcile, violates his own parole after pulling a gun on a paparazzi photographer. In the end, not only does he lose out on owning several franchise restaurants, but he has to sell his own to pay for his son's bail.
His last conversation with Frank is the biggest example of the sacrifices Frank has to pay for his ambition. After hearing about Freddy's troubles in the paper caused by Tusk and in the middle of a huge marital scandal involving Frank's wife, international tensions, and everything else on his plate, Frank drops everything and heads to Freddy's apartment to help any way he can, telling the audience that he "does not leave a man bleeding on the field". But Freddy has had enough of the whole mess and wants no part of Frank's offer to help, especially after Frank tells him that he has to distance himself for political reasons. When Frank leaves, Freddy doesn't even call him a friend, just "a good customer".
First Lady Walker phones Claire and calls her a good person as the Walkers are finalizing their departure from the White House, an exit engineered by Frank and Claire. Claire doesn't take it well.
Rachel being forced to break up with Lisa, the one person she'd managed to forge an intimate connection with since the series' premiere, all because Doug felt disconcerted by the relationship. Worse because when she breaks up with Lisa, she's not allowed to tell her the real reason for it, with Rachel instead saying that she never loved her, sending her over the Despair Event Horizon.
Lucas' conversation with Janine before he's about to serve his term in prison.
Lucas: He's going to get away with it, isn't he?
Janine: (beat, tears in her eyes) Yeah.
Basically Adam's entire ordeal in Chapter 22 ends up as this. His relationship with Claire is wrecked due (once more) to the war with Tusk, his professional career will probably be damaged beyond repair, and it's hinted that his fiancée holds resentment at him for complying with the Underwoods' final solution.
Everything that happens to Megan Hennessey, the marine private who was sexually assaulted. Despite her courage to come forward and help Claire with her sexual assault bill, her manic depression and the stress of events undoes any effort she makes towards recovery.