- During an arc where the family travels to Washington DC, this exchange at the Vietnam memorial:
(Roger is looking at the wall with a sad expression)Andy: He was your father's best friend's older brother.Peter: I'm an older brother...
- One strip has Jason standing in front of a snow dinosaur and imaging what he could do if it were real. The last panel has Jason walking away disappointed, and the snow dinosaur sheds a tear.
- Roger's favorite cartoon strip since he was a kid, Captain Goofball, gets replaced by a new comic strip and Jason comments on how Captain Goofball was dumb. Roger's reply is almost heartbreaking. "Captain Goofball was NOT dumb! At least, not twenty years ago when it really mattered!...to me..."
- The beginning of the "His Codename Was The Fox" arc, where Roger realizes that, out of his graduating class, he is the only one that never really went on to be some kind of professional success. His facial expressions alone are very telling in terms of how he's taking the news. It was as though, for 2 or 3 days, Amend decided to deconstruct Roger's Butt Monkey status rather than simply play it for laughs.
- One storyline early on had Jason wake up at midnight on Christmas to open all his presents. While the first two strips were funny, the following three showed Jason deeply saddened by not being able to share the joy of opening presents with his family. The final one ends on a Heartwarming Moment, though, as Andy gives Jason a present meant for Roger for him to share. Granted, Roger didn't volunteer that present, but the way he held Andy in the last panel made it clear he understood.
- Roger: I thought I wanted that sweater.Andy: Someone else wanted it more.
- When Jason is hospitalized for falling off the roof, Peter, who feels responsible, stays up all night with him and gives a very tearful, heartfelt apology. Anyone who has accidentally hurt a sibling knows exactly how he feels.
- Amend's tribute to Steve Jobs.
- Even more depressing when you realize that they scrapped the old iFruit for a new one resembling an iMac G5 starting in 2007.
- Andy's mother issues, which come with her being a "Well Done, Son!" Guy and The Resenter for the fact that apparently everyone prefers Andy's mother to her, even her friends from the seventh grade. Most people in the story arc blame Andy for her mother issues, even though they've been building up over time and they don't go away overnight.
Andy: How do you think it makes ME feel?!Grandma: Not as half as bad as it makes me feel.Andy: Gee . . . a perfect answer. How surprising.
- Andy even mentions that she takes a lot of antacids, and not for the calcium.
- Even worse is when she tells her mother that Roger called the latter "perfect" and has never said that about Andy. In addition he joins in on the kids celebrating that "Grandma" is coming for Christmas on the grounds that she gives really good presents, and keeps chiding Andy for being resentful even as he spends more time with "Grandma". There's a Double Standard in place given that when Roger was feeling inadequate about not being a success, Andy was comforting him, but when she was feeling inadequate, he didn't return the favor. What the hell, Roger?
- And for "Grandma" herself, seeing that just by being The Ace and a Cool Old Lady that she's enabled Andy to develop these issues. She's rightfully upset when she hears Andy grumbling about how she's waiting for her mother to leave, but is willing to listen to her about why Andy is feeling this way. The next day, after switching their presents to the kids, she tells Andy You Are Better Than You Think You Are and allows Andy to have the limelight on Christmas.
- The followup Thanksgiving arc is Played for Laughs, mainly, with Andy stressing over making the perfect dinner and not allowing her mother to help. She tries to impress her mother by making an elaborate dinner, which ends up going in smoke. Literally. What makes it a Crowning Moment of Heartwarming AND a Tear Jerker? After Andy gets Heroic BSOD following the disaster of a dinner, "Grandma" tells Andy that she was the same way with her mother, showing that she's not all that perfect and was once a Lethal Chef as well.
- The arc right after Hurricane Katrina starts with Andy asking Roger if he remembers the weekend in New Orleans right after they were married, and "how alive and wonderful it was". After he says, "How could I forget?" Andy replies, "Let's hope no one does."
- And it ends with Jason, of all people, deciding to give his allowance to hurricane victims, saying "it's the right thing for me to do." Roger then gives him a hug, saying it's the right thing for him to do.
- The strip that came out after 9/11. Andy and Roger are seen watching TV with sad looks on their faces. The last panel shows Andy crying and Roger asking "Wasn't there a time where we enjoyed watching television?"