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Tear Jerker: Cake Boss
Yeah, there were cakes in the Season 5 finale. Don't ask me what they were; the main focus of the episode was the news that Buddy's mother has been diagnosed with ALS.
Early in season three of Next Great Baker, contestant James Brown announced that he had been diagnosed with a benign brain tumor and would leave in place of whoever lost the competition. Cue tears from almost everyone, including guest judge Lou Ferrigno.