- Richard the raccoon might be a nod to a kids' magazine entitled Ranger Rick, whose mascot was also a raccoon.
- There's one early strip◊ where Amy has a nightmare that Timmy is an evil genius. She wakes up Tom and informs him that they are never watching Family Guy again. (The show isn't mentioned by name, and Tom wonders if Amy means The Venture Bros..)
Sabrina: "What comes to mind when you hear 'Sabrina?'"
Amy: "Other than 'Teenage Witch?'"
- Zig's cross-country take-down of all of her cyber-bullies was a weeks-look remake of the ending to Jay and Silent Bob Strike Back. She even leaves◊ the duo themselves to beat up one of them.
Zig Zag: "All yours, fellas."
- Zig also◊ pulls a Zii on one of her detractors. It's even titled "Menage a what?". However, unlike the base breaking actions of Zii, this one is with an already divorced single mother, and not the cause of said divorce.
- And let's not forget their Shout-Out to The Simpsons.
Ned Flanders lookalike: "Good Lord! That's the loudest profanity I've ever heard!◊"
- Carli and Spike... now where have we heard those names before?
- "Her name is Lena! I have no idea where they keep getting "Mary Sue" from!" The strip's title replies, "Maybe TV Tropes?"
- The appropriately-anthromorphied Grim Reaper winds up looking more like Death of Rats from Discworld.
- The hospital where Sabrina stays after getting assaulted was apparently founded by Grumpy Cat◊.
- At the end of the Flash Forward, Sabrina explains it to R.C. He asks if she saw a space probe with a flute at the end.
- On a similar subject, Zig's therapist has another client who goes by the name "Barclay".