- In Post-High School Reality Quest, Tristan's favorite shirt is an xkcd T-shirt.
- ANNO: Mutationem: One achievement is called "Science, it works!" that's obtained by enhancing an item with machinery.
- Borderlands 2: The Hyperion Contract #873 mission: The Morningstar has the "FPS Mod" which was made by project "Ex-Kay Seedy".
- This strip of The Whiteboard has Black Hat Guy as one of the players in a paintball game getting some ammo.
- Black Hat Guy also appears in this strip of Arthur, King of Time and Space snarking about AKOTAS's "gritty realism".
- #249: Chess Photo is referenced in the bonus panel of this Mr. Lovenstein.
- Questionable Content:
- Marigold has an xkcd T-Shirt.
- There's a large crate marked "CAUTION" in the background of this strip. The Alt Text explains that the crate contains a large bobcat.
- Saturday Morning Breakfast Cereal often references xkcd, including an alt-image reference to an alt-text reference xkcd made to SMBC.
- Irregular Webcomic! has done a couple of xkcd pastiches. This one refers to the various "My Hobby" strips, geohashing, having a ball pit in your apartment, and someone announcing they're "from the internet".