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• Probability, especially for relatives of cancer victims and moreso after Randall himself later announced that his fiancee has breast cancer.
• Lanes, especially the massive final panel. The Alt Text just drives the point home further...
  • As a lymphoma survivor, this comic made me cry like no other
• Spirit
  • For extra anthropomorphism point, consider Spirit's mission patch◊. You did well, lad. We're so proud of you.
• Helping
• Well
• Science Valentine
• Temper For anyone that grew up with this man.
• Dark Flow, especially for anyone who lost a parent. Even more especially a mother.
• Diode The Alt Text makes it even worse.
• Secrets
• "Will it ever stop hurting?"
• "but secretly we're just afraid to tell it to love"
  • Although it does have a relieving Mood Whiplash via the Alt Text.
• Forgetting
• Eternal Flame Especially the alt text. *
  This comic was made as a tribute to Steve Jobs
  after his recent death.
• Laser Scope. It may be strange or funny at first but then you read the alt text...
• Friends... Dear mother of God!
• Dream Girl, although this may help.
• In a similar spirit: Etch-a-Sketch.
• Nightmares. Part Tear Jerker.
• The Barrel Boy story, especially these three.
• Never. Most of these at least have a sense of humor, but this... doesn't.