- Pop Team Epic: Popuko and Pipimi are in planes shooting a big, anthropomorphic bear. He slashes the girls out of spite, but they fortunately have 9998 lives left. The bear becomes completely annoyed because of that.
- Super Smash Bros. Ultimate: World of Light: A spirit appears in chapter 24 that strongly resembles Goopy le Grande.
- Toon Zone Wrestling: Some of the minority sponsors include the Delicious Last Course.
Music
- SiIvaGunner: "The Moon (OST version)"
is a seventeen minute long cover of Cuphead's tutorial theme, riffing on GamesBeat editor Dean Takahashi's infamous failure to get through said game's tutorial.
- Cognitive Crisis: Cuphead appears as an enemy.
- Fall Guys: A large subset of Legendary costumes in Fall Guys, along with some live events, are crossovers based on characters from other franchises. The "Cuphead" emote was also introduced; when used, your bean finger guns to the side like the titular character does, in a staggered motion like in an old film reel.
- Guacamelee! 2: Like in the first game, towns display a plethora of background posters for upcoming lucha matches and product advertisements. One of them is "La Gran Cabeza de Copa".
- Indiecalypse: One of the later levels is called Bloodhead: Don't Deal with the Devil. It involves a cartoonish version of Violet dealing with enemies and her menstruation by shooting at it from a plane. She can parry blue objects and use the collected cards for a special attack.
- Super Smash Bros. Ultimate:
- In January 2020, a Cuphead costume for Mii Gunner was made available as paid DLC, with the music track "Floral Fury" being included with it.
- Spirits of Cuphead, Mugman, The Devil and King Dice were introduced in February 2020, initially being exclusive to a special Spirit Board event called "Ready? Wallop!".
- All Saints Street: Ira owns a Cuphead pastiche called "Mughead", who himself is just a mug with arms and legs, Cuphead's face, and Mugman's nose.
- The Brothers Quack: The cups in "Homemade Havoc" resemble Cuphead and Mugman.
- Dark Secrets of Garry's Mod: Medievil finds a device in Medievil: Nincs hazaút (Medievil: No way home) that he uses to travel between dimensions. He travels to a dimension where he drinks Mugman to death, Cuphead of course does not take that kindly and tries to kill Medievil as revenge.
- Hellsing Ultimate Abridged: When Satan shows up, an instrumental version of the opening theme of Cuphead plays.
- Honest Trailers: There is an episode that covers Cuphead.
- LuigiFan00001: Calla Marie appears as a boss in the 15th Peashooter And Paco's Adventure episode.
- Meta Runner: Episode 7 sees Theo shooting beams of light out of his fingers in a manner very similar to Cuphead.
- Ollie & Scoops: Old Crumplecranks, from the episode of the same name, physically resembles the Devil from Cuphead.
- Zero Punctuation: Ben Croshaw does a review on Cuphead once.
- Villainous (Cartoon Network): In Dreadful Dawn, when Sunblast is throwing the villains around like a lasso, one of them drops a cup that looks like Ms. Chalice's head.
