"See, this is another sign of your tragic space dementia, all paranoid and crotchety. Breaks the heart."
— Malcolm Reynolds, Firefly
"They think I'm crazy. But I know better. It is not I who am crazy. It is I who am mad!"
— Commander Hoek, The Ren & Stimpy Show
Even unknown, and monster-peopled by superstition, Earth had not been as cruel an environment as space; nor had a caravel been as unnatural as a spaceship. Minds could never have disintegrated as quickly in mid-ocean as between the stars.
— The Burning Bridge by Poul Anderson.
"I fear that when our master reached for the stars, he came down with a touch of...space madness."
"It is so dark around, no life, no hope, no sound, no chance of seeing home again ... Somebody help me I'm missing, somebody help me I'm missing now touch with my mind, I have no frame ... no people around, no-one to touch. I am now quite alone, part of a vacant time-zone, here floating in the void..."
— Van Der Graaf Generator, "Pioneers Over C"
"Additional: Our biggest enemy is going space-crazy through loneliness. The only thing that helps me maintain my slender grip on reality is the friendship I share with my collection of singing potatoes."
— Holly, Red Dwarf, "Queeq"
"How will Man's subconscious mind react to his first experiences with space travel? Will he not suddenly be aware of his precarious situation, trapped in a tiny metal box, floating through the incomprehensible nothingness of space?"
Tumii: He has already certified free of transmissible celestial dementia.
John: We're callin' it space madness.
— Farscape, "Coup by Clam"
"You have given me the incident counts for the colony, and I say that colony has been in operation for two and a half years. That much time in deep space is inherently dangerous, and the people attracted to this line of work are too."
— Captain Mathius, Dead Space: Downfall
"There's no relative direction in the vastness of space. There's only yourself, your ship, your crew. It's easier than you think to get lost."
— Commodore Paris, Star Trek Beyond