Zig Zagged: Bob prepares to Ascend to solve some problem, but at the last minute it seems he doesn't need to. He goes through with it anyway, but he fails and remains a normal human or dies. But it seems that it did work after all. But he wishes it didn't because now he's stuck at a cosmic desk. Or Is He?
Enforced: Bob's actor wants off the show. The writers want to leave open the possibility of reusing the character, or just want to give him a dignified, awesome sendoff that completely inverts Dropped a Bridge on Him, so he gets Soap Opera Disease and the main characters manage an Epic Hail so that Sufficiently Advanced Aliens take him back to their planet to convalesce for an unstated amount of time.
Lampshaded: When Bob Ascends, a Genre Savvy character waves and shouts, trying to get the attention of the aliens taking him so they'll take him too.
Invoked: Bob knows or even researches a magic ritual to Ascend, and uses it.
Exploited: Bob owes Alice a favor. Bob Ascends. Alice can now ask for practically anything.
Discussed: "Bob died? Really? How?" "It was complicated. I'll ask him next time I see him."
Deconstructed: Bob Ascends. His friends still grieve for him, because they may know he's Ascended but it's hard to believe, and they miss him because they don't get to see him anymore or know what he's doing. If he does come back, he now believes wholeheartedly in Blue and Orange Morality and/or is now dangerous. If it's too easy to Ascend, the wrong people may do it.
Reconstructed: Bob's friends miss him, but he leaves mementoes for them now and then and pops up to offer solace in times of need. A need to Beware the Superman is hinted at, but Bob ultimately does the right thing despite the lure of power, or his actions actually were serving the greater good even though it didn't look that way.
Plotted A Good Waste: Bob Ascends; it's set up as a big deal, it comes with powers that might or might not give him Story Breaker Status, the audience is left wondering what it will mean for the character and the show... but it's just because this was just the easiest way to put him on a bus, and he's never discussed again.
Played For Laughs:
The Butt Monkey Ascends... and is still Butt Monkey in the new dimension he's now stuck in.