- Mira's death in the Action Prologue at the hands of the Mimetic Beasts is not only sad, but also disturbing.
- Anna falling to her demise when she is about to be evacuated.
- Goh's Unstoppable Rage following his wife's assumed demise in Gakazono High's attack caught some off-guard.
- Goh gets brutally injured by 16's spikes in "Shizuru's Comeback".
- In "A Girl from the Sky", the Mimetic Beast destroys the shuttle and attacks Cosmo Base, both leading to the deaths of Lou's uncle and father. Later on, Cosmo Base undergoes a collision course for Earth.
- Shizuru's death at the hands of the Mimetic Beasts at the end of "Those Who Have Departed".
- Anyone who is infected by the Insania Virus can cause them to go insane with rage, become mutated and eventually die:
- Max's influence cause him to go insane to the point that he grabs Mira, destroys Dannar Base and eventually getting mutated.
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