Baby. Basically a more family-friendly version of the Thing, Baby is a supremely vindictive mutant parasite that infects all but a tiny handful of people on Earth, taking complete control over them, and when he picks a main host body his power warps it to completely unrecognizable levels while enhancing its abilities. Even worse was that in his earliest stages instead of controlling people he infected he ate them, wiping out entire spaceships full of passengers.
Baby's victims. When they're infected, they seem to retain their memories, powers, and personalities from before the infection. For example, Bulma is still able to invent, and all the saiyans are still able to go super, meaning their talents can now be used for evil. It gets especially bad when we see things like a possessed Trunks fighting his closest friends, a possessed Gohan making quick work of his former mentor Piccolo, and Gohan and Videl talking down Pan, their own daughter, seemingly for no real reason other than simply pure malice.
Shenlong's Evil Counterpart. Just when it seems like all the character's problems can be fixed once again by the dragonballs, they see a dark, menacing version of Shenlong who promises that things will get worse before they get better.
The arc where Pan is turned into a doll. She can't make a sound, Goku and Trunks have no idea where she is, the bastard is trying to undress her, the doll room is filled with other people who seemingly were turned into dolls a long time ago and died (they are at least completely silent as one can't hear their thoughts like one can with Pan's), Goku and Trunks walk by the room many times and she just sees them leave... It doesn't help that the Spanish episodes were shown Out of Order so if one were unlucky one would never know how it ended....