Self-Guarding Phlebotinum

For some reason or another, you can't get to the McGuffin because it produces a forcefield or has a forcefield surrounding it. Possibly due to it being a Loyal Phlebotinum or Empathic Weapon. Maybe there is an enchantment upon it that causes it to repel a certain type of being, such as demons, or maybe it's a curse that will let you touch the object but causes adverse side effects, such as death. Having proper Phlebotinum-Handling Equipment may help.

Examples

Anime and Manga
  • In InuYasha, the sword Tessaiga has a barrier around it that prevents demons from touching it. Humans and half-demons can touch it without pain, however.

Literature
  • Harry Potter and the Half Blood Prince: The cursed opal necklace that kills anyone who touches it. Bonus points for being a Chekhov's Gun from its brief mention in Chamber of Secrets.
  • The eponymous Silmarils from The Silmarillion burned any evil creature touching them, such as Morgoth and Carcharoth, while sparing the good-aligned heroes such as Beren and Eärendil. Becomes a plot point late in the book, when two remaining sons of Fëanor (Simarils' creator) finally get their hands on their "heirloom"—only to find that the Simarils reject and burn them, after all they have done to get them back.
  • In Lensman, the titular Lens will kill anyone but its owner if it's not being worn, to prevent anyone from impersonating the Lensmen. Boskone found this out scientifically in the prequel, by forcing enough workers to hold onto the thing and die until they were satisfied it wasn't coincidental.
  • In The Quest of the Unaligned, any aligned mage who touches the Prince's Crown will be burnt to ash unless they are "buffered" by the intervention of one of the rare unaligned mages.

Film
  • The Wizard of Oz. When the Wicked Witch of the West tries to take the Ruby Slippers from Dorothy's feet, they generate an electric shock field that prevents their removal.
    • Averted in the original book The Wonderful Wizard of Oz. The Silver Shoes can come off like any other shoe, and at one point the Witch uses an invisible iron bar to trip up Dorothy, causing one Silver Shoe to fall off and allow the Witch to grab the shoe for herself.
  • Colossus The Forbin Project: The titular Master Computer's main defense is that it was built inside its own radioactivity spewing nuclear reactor.
  • Aladdin: The Cave of Wonders, where Aladdin first found both the flying carpet and Genie, would only allow one who was worthy, "The Diamond in the Rough", to enter. Even then it would not permit Aladdin to touch any of the treasure except for the lamp.

Live-Action Television
  • The Charmed Ones' Book of Shadows won't let you touch it if you happen to be evil.
    • There were also various amulets and charms which protected against evils including crystals that when placed in a circle formed a cage of energy that one couldn't cross, whether to get in or out.
    • Also once when Piper pulled Excalibur from the stone, the sword would let no one else [but her touch it, though a demon used a spell to amass a bunch of power and take it from her.
    • In season 7 Pandora's Box protects itself by teleporting to its next guardian when its current protector dies.
    • And yet again from Charmed, the Grimoire, the Evil Counterpart to the Halliwell's Book of Shadows would not let any good being come in contact with it.

Tabletop RPG
  • Dungeons & Dragons
    • adventure C2 The Ghost Tower of Inverness. The Soul Gem is surrounded by an invisible force sphere which must be broken by the PCs if they want to retrieve it.

Video Games
  • In NetHack, artifacts may blast you for some damage if you try to touch them if you fail certain conditions: wrong alignment, negative alignment record, or polymorphed into (or naturally) something it specifically attacks.Exception  Intelligent artifacts are more forceful in this regard: they'll always blast users they don't like, have more powerful blasts, and those tied to a certain role can also blast characters of the wrong role, or even evade their grasp note .

Web Original
  • Rosaphir stone in Noob. If you want to pick it up, you'd better be ready for a Mirror Match.

Western Animation
  • In the Star Trek: The Animated Series episode "The Jihad", the Soul of the Skorr is protected by a force field.
  • Adventure Time: In "City of Thieves," the King of Thieves' tower has a barrier around it that repels all thieves.
  • The Omnitrix from Ben 10 generates a small field around itself when someone who is not the person who it is currently attached to tries to touch it. You can get around this by just killing the current user, of course...
  • Puppy's locket in The Smurfs, which is said to contain "the key to all magic", shocks everyone who tries to open it with a lightning bolt except for Baby Smurf.