Megalomania may refer to:
- The delusions of grandeur and godhood prompting a villain to proclaim A God Am I.
- Megalomania: A shonen manga by Daisuke Hiyama.
- Megalomania: A Science Fiction novel by Ian Wallace.
- Megalomania: A 2000 comedy film.
- MegaLoMania: A Strategy RPG by Sensible Software.
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