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- The Chronicles of Narnia: "Once a king or queen in Narnia, always a king or queen in Narnia." Important because it is not unknown for children from Earth to be taken to Narnia, installed as king or queen, returned to Earth, and then be returned to Narnia years, decades, or centuries later at which time a new ruler may be in place.
- The Reynard Cycle: When you become a Calvarian blood-guard, you are considered one until you are dead. Of course, you may die before you get that far.
- In A Song of Ice and Fire, service as a maester, in the Night's Watch, Kingsguard, and several religious orders is lifelong. The Night's Watch' traditional funeral rites end, "Now his watch is ended."
- In The Wheel of Time, service as an Aes Sedai (female magic-user) is intended to be lifelong. When the new Amyrlin Seat (a cross between The Archmage and a female Pope) breaks tradition by demoting an Aes Sedai to Accepted (apprentice), it causes a major scandal. Even when it's discovered that the Restraining Bolt that is a major part of their identity as Aes Sedai shortens their lifespan by several hundred years, there is a significant faction that would rather die as Aes Sedai than "retire" and have their lifespan restored.
- The D-class of the SCP Foundation are used as grunt labor and guinea pigs, taken from death row or third-world prisoners (and in times of shortage, from the general populace) for a promise of a shorter sentence, and are executed at the end of the month. A life sentence doesn't necessarily imply a long sentence.
- In the Pacesetter Games version of Chill, all PCs are required to be members of S.A.V.E.. This is enforced by stating that any member of S.A.V.E who is kicked out for breaking the rules will be killed by supernatural monsters within the week, with no way to avoid death.
- Warhammer 40K: Space Marines serve until they die or they are too grievously wounded, at which point they may be put inside a Dreadnought to continue serving pretty much eternally.
- Penal legions are pretty much this, since the idea is to redeem yourself of a particularly hideous crime by going on the most dangerous or suicidal missions.
- Fire Caste warriors either serve until death or face trials every four years of service to go up a rank, at which point they can become advisors.
- Warhammer: Dwarf Slayers are individual dwarfs who have dedicated themselves to dying in battle against a particular enemy (Troll Slayers, Dragon Slayers, Demon Slayers etc.) to atone for some past dishonor. The most successful ones are technically the biggest failures, since they're bad at the "dying in battle" part.
- The "In For Life" flaw in Mechwarrior (the tabletop roleplaying game, not the video game of the same name). You're part of an organization for good or for ill. Normally, this most often applies to organized criminal groups like The Mafia, Yakuza, or The Triads and the Tongs. It can also apply to things such as elite government organizations, especially all forms of Secret Police.
- In West Side Story, "when you're a Jet you're a Jet all the way, from your first cigarette 'til your last dying day."
- In Mass Effect, there's "no such thing as a former Spectre".
- Likewise, in Dragon Age, there is no such thing as a former Grey Warden, as the Taint they voluntarily expose themselves to during their Joining ritual is incurable. There is a single known example of a Grey Warden being completely freed from the Taint—Grand Enchanter Fiona—but she was the only success of a centuries-long research by an inhuman intelligence that is yet to be replicated.
- Common for many gangs and other criminal organizations. For examples, see Resignations Not Accepted.
- Marriage is traditionally this in most cultures. As it is currently practiced in modern Western society, it is averted roughly as often as played straight. Most people still keep the "until death do you part" bit in their vows, although Fridge Logic sets in if one or both spouses have one or more living ex-husbands or -wives. If a couple persists in marriage due to the lifelong commitment involved despite being miserable, it's an Awful Wedded Life.
- "Once a Marine, always a Marine." Largely symbolic as they are not (usually) literally expected to serve for life. Military commitments in general are typically relatively short, with service terms between two and six years being common. While many folks proceed to get out of the military and get another job or go to school, some folks will "re-up", possibly with the intent of serving until they reach retirement age, such folks being known as "Careerists" or "Lifers".
- Most royalty and nobility are this way, with "Dowager" added to the honorific of a widow whose title derives from a deceased husband and whose effective authority has passed to an heir (e.g. "Dowager Countess").
- Many religious orders, such as the Catholic priesthood, are for life. While there is provision in Canon law for popes to resign, it is very rare, making the papacy functionally this. It was most recently averted by Pope Benedict XVI, the first living pope to step down in centuries. Similarly, once baptized Catholic, always Catholic, at least in the eyes of the Church — no matter what the "fallen sheep" in question might have to say about it. Said "fallen sheep" could convert to Buddhism, abandon organized religion altogether, or turn outright atheist, but as far as the Church as concerned, they're still Catholic.
- Life imprisonment is a common punishment for severe crimes such as murder, especially in jurisdictions that lack the death penalty. See also: Longer-Than-Life Sentence.