A novel by Jeffrey Eugenides published in 2002 which went on to win the Pulitzer Prize for Fiction.Calliope (later Cal) Stephanides was born with a rare genetic condition that caused her to look externally female, but in adolescence begin developing male characteristics.That's not really the point, though. Most of the book recounts the story of Cal's parents and grandparents who happened to make such a trait possible.A very well-written book, although it comes with a few warnings: much of the plot focuses on Brother-Sister Incest, and one character turns out to be a historical figure, Wallace Fard Muhammad.
Middlesex contains examples of:
A-Cup Angst: One of Calliope's big concerns while she still thought she was a girl.
The Beard: Jimmy Zizmo is this for Lina, who is a lesbian and had to leave Bithynios after her affair with another woman was discovered.
Blind Mistake: The fact that the doctor who delivered Callie was nearsighted and didn't notice her unusual genitalia had huge effects on the lives of everyone involved, especially Callie.
Body Horror: The realization that Calliope's body is not normal has aspects of this.
Detroit: The book is set in Detroit and its tonier suburbs, and events in that city repeatedly interplay into the lives of the Stephanides family. Notable examples include Lefty's ill-fated job on the assembly line at Ford, bootlegging across the Detroit River to Windsor during Prohibition, the founding of the Nation of Islam, and the 1967 riots and the fallout thereof.
Elegant Classical Musician: Milton's clarinet skills are initially what make him attractive to Tessie. They even use it in foreplay.
Pass Fail: It's somewhat complicated, but Jimmy Zizmo, Cal's maternal grandfather, made himself the persona of Wallace Fard Muhammad (a real person who founded the Nation of Islam) after faking his death. Additionally, the way his origins are discussed by the characters and the narration, Zizmo could genuinely be of mixed ancestry and passed as Greek, Turkish, and Polish before faking his death and assuming his new identity; or he could genuinely be Greek, Turkish, and Polish, and be passing as a mulatto. The novel is delightfully ambiguous on this.
Pronoun Trouble: Cal runs into a bit of this, and even trying to talk about them in this article is a bit awkward.
Raised as the Opposite Gender: A non-standard case. Cal's parents did specifically want their second child to be a daughter, but bringing their baby up as a girl was clearly because of mistaking it as one, with no intention of forcing fake gender identity.
Romantic Two-Girl Friendship: At Calliope's all girls school this is stated to be common, since according to Cal, energy that is normally reserved for crushes on boys gets redirected into friendships with other girls instead.
The Runaway: Calliope becomes one after realizing that they intend to surgically alter her body, so he cuts his hair, remakes himself as Cal and ends up in San Francisco as part of a strip joint show as "Hermaphroditus" and meets another intersex woman.
Secret Keeper: Lina is this for Desdemona and Lefty, due to having secrets of her own.
Shown Their Work: The amount of research the author did on Cal's condition really shows.
Transsexual: Cal goes through a similar process when he decides to start living as male.
What Happened to the Mouse?: In story, Cal comments that people are probably wondering what happened to Desdemona since she seemingly drops out of the story. Turns out that she's still alive and has just retreated to her room, and lives long enough to see Cal's new male persona and confess the reason he's the way he is.
Wrong Genetic Sex: As the result of 5-alpha-reductase deficiency. Genetically, Callie is 46,XY, but lacks the enzyme that converts testosterone to its active form. Thus, he has cryptorchid (undescended) testes, no ovarian or uterine structures, a nonfunctional vaginal pouch, and a microphallus (such that it's repeatedly mistaken for a larger-than-normal clitoris, both by Callie and by several doctors).