A novel by Jeffrey Eugenides
published in 2002 which went on to win the Pulitzer Prize for Fiction.
Calliope (later Cal) Stephanides was born with a rare genetic condition that caused her to look externally female, but in adolescence begin developing male characteristics.
That's not really the point, though. Most of the book recounts the story of Cal's parents and grandparents who happened to make such a trait possible.
A very well-written book, although it comes with a few warnings: much of the plot focuses on Brother-Sister Incest
, and one character turns out to be a historical figure, Wallace Fard Muhammad
Middlesex contains examples of: