Warning: All spoilers will be unmarked!
- Being a member of the Tokiha family appears to be a prerequisite for heartwarming moments in My-HiME. Mai gets one in the last episode, when she finally says "I love you" to someone, after spending most of the anime actively avoiding it. The recipient is the person you'd least expect (or most, depending on your character preferences): Mikoto, right in the middle of a risky and potentially life-ending Cooldown Hug. Mikoto, who'd been struggling with figuring out "that thing called love" for the last few episodes, returns the favor shortly after the Grand Finale.
- Her sickly younger brother Takumi is also involved in one earlier in the series. When confronted by Akira, who attempts to kill him for discovering that she's really a girl, Takumi tells her to go ahead with it, because he feels guilty about being a burden on Mai under his condition. Hearing this, Akira softens up and tearfully tells Takumi not to die on her, and even saves his life when he has a seizure right there.
- There's also another instance in the manga, where a sick and exhausted Mai (who up until that point had been the Mai-HiME poster girl for Don't You Dare Pity Me!) finally admits — both to herself and to Yuuichi — that she's happy he showed such care and concern for her when she fell ill.
- There's also the special to Episode 25, where Natsuki talks about how being friends with Shizuru, Mai and Mikoto helped her open up, notes that Shizuru's feelings for her and Mai and Yuuichi's feelings for each other convinced her that people could not live alone, and ultimately thanks everyone who has been there for her. Considering how common Love Makes You Evil is in this series, it's nice to see a case of it changing someone for the better.
- The ending, and especially seeing Break the Cutie victim Akane finding happiness.
- Natsuki shielding Nao from Shizuru's wrath. Listening to Nao talk about what happened to her family, Natsuki realizes that they're not so different. She also realizes that it was her friends, particularly Shizuru who made the first ovation when they were younger, who kept her from becoming as dark as Nao had. She realizes at that moment that Shizuru is her MIP, and is able again to access her powers.
- Natsuki bears witness to Mai's grief when Yuuichi dies, and though it is strongly hinted that Natsuki Hates Being Touched, she puts a hand on Mai's shoulder to comfort her, and when Mai shakes her loose, Natsuki fights back her own tears, then hugs Mai from behind until Mai falls to the ground to grieve, while Natsuki comforts her.
- Natsuki's forgiving Shizuru for for whatever happened that night. As another Troper pointed out in Fridge, it isn't important what actually happened so much as Natsuki actually choosing to forgive. And she decided to snap Shizuru out of her Psycho Lesbian phase with a Big Damn Kiss, restoring her to sanity. Even Natsuki's Taking You with Me was done out of love rather than vengence or malice.
- The final battle between Natsuki and Shizuru, in its own unique way. Natsuki knows at this point that she's Shizuru's most important person. And she's come to realize that Shizuru is hers. Only one HiME can be left standing to face the Obsidian Prince. Natsuki could have simply taken herself out, and it would have met the qualifications. But it was a matter of importance to her to face Shizuru and do exactly what she did, cut through Shizuru's insanity and bring her back to herself before they went out together. Saving her friend's soul was what was most important to her.
