WARNING: Spoilers Off applies to Funny Moments pages per wiki policy. All spoilers will be unmarked.
- The Running Gag of John mistakenly thinking "Jell-O" means "goodbye."
- The Running Gag of Stone mistaking siblings for lovers.Loud/Carl: She's my sister. We have the same parents.Stone: I know what a sister is!
- During a vehicular shoot-out in a shopping mall, John takes a moment to look at the mall's directory to figure out the exit. "Oh, there's a Foot Locker!" And on the way out, drives by said Foot Locker and snatches a pair of shoes off a display.
- John's payment for one delivery is a pair of Bosch brand windshield wipers. He later talks about them to himself while cleaning a thief's blood off his windshield.John: Tension springs keep the blade flexible for premium wiping performance.
- John enters New San Francisco for the first time. He might be a Badass Driver but he's never had to parallel park before.
- Stone tortures John and Quiet by making them fill out huge stacks of paperwork and playing "Barbie Girl" at maximum volume.
- Quiet finds and kills Shepard while he's in the middle of masturbating to a lolicon comic. The sheer indignity of Shepard's demise helps shift what happened from horrific to hilarious.
- She later offhandedly reveals this to John in her farewell letter. John reacts appropriately.
- Sweet Tooth is a psychotic Monster Clown whose best friend is a paper bag but he thinks John is weird for talking to his car.
- Sweet Tooth's crappy first show is based on promotional videos from the hotel he stays in. He also serves John and Quiet steaks made from Siegfried and Roy's white tigers, which have since gone feral and taken over the fourth floor. What makes it better is that John remarks that the steaks are actually delicious.
- Granny Dread worked on the "Granny Sutra", a book full of sexual positions one can do in a car. She later gifts it to Quiet.
- Miranda and Amber's breakup is a Noodle Incident. All we know is that Miranda pushed Amber out of a truck after Amber poisoned her.
- Sweet Tooth was institutionalized when, as a child actor, he was outshone by his dog costar Billy and killed him in front of a live studio audience. A newspaper clipping in his cell shows that Billy's funeral got better ratings than his trial.
- Sweet Tooth reveals he once killed his roommate for saying Chris Kirkpatrick was the best member of *NSYNC.
- Sweet Tooth comes out of the asylum and finds his followers shot by Stone. At first he thinks Harold did it.
- And he doesn't even seem all that angry about it. He sounds more annoyed, as if Harold just ate the leftovers he was saving for later.
- Mr. Slam's nickname comes from his ability to smash watermelons with his giant penis. When John is ambushed in his bar, he's mostly outraged that one of these performances was interrupted.
- John and Quiet walk into Calypso's lair, which is a dark, ominous hallway full of mist. Rather than being scared, Quiet geeks out over how well-done it is.
- Preacher orders his men to crucify John only to realize the cross is already occupied by a dead body. He then berates his gang for not removing the victim when he died because now the "vibe" is ruined.
- The Affably Evil One-Scene Wonder vulture that robs Quiet while letting her vent about John and sharing his own story of his late ex-girlfriend.
- John's attempts at adjusting to life in New San Francisco.
- He might be a Badass Driver but he fails at learning to ride a bike.
- He tries to pay a pizza delivery guy in bullets.
- The valuable package that Raven sent John all the way to New Chicago to deliver is a pint of ice cream. And Calypso gave her the wrong flavor.
