This moment from "The Curse". Roderick, after stopping Claire from killing Emma, makes a great facial expression of Nothing To See Here to the other Carollism followers.
Whenever Claire openly mocks Joe's career as a novelist. What's even funnier is how angry it makes Joe, who usually displays Nerves of Steel.
Claire: You're a brilliant teacher, Joe, it's just a shame it never translated to your writing.
In the middle of a home invasion, Claire assures Joe he can trust her with her hands untied. Joe is skeptical, considering the last time he trusted her she stabbed him in the gut several times, but relents. As soon as he turns his back on her, she breaks a wine bottle over his head, stabs him in his first knife wound with a fork, kicks him in the face, and helps the couple he captured to escape.
Joe: I have been stabbed with a knife and a fork...
Joe: It's a motif, Claire!
The fact that Joe is disguised as a bearded Good Ol' Boy for the first few episodes of season 2. If the Uncanny Valley effect of mixing his naturalpersonality with an appearance straight out of Duck Dynasty isn't hilarious, his attempts at a thick country accent sure as hell is.
Mandy laying with her head on Joe's lap, watching a documentary special on his murders:
Mandy: Did you play too many video games as a kid?
Mandy: Did you watch too many horror movies as a kid?
Giselle's repeatedly begging the Twins to let her kill Carlos, and then pouting when they refuse her.
Luke: Sorry, baby, I forgot. He's still breathing; you can finish him off if you want.
In "Resurrection," after killing Heather Clarke, Luke helps himself to her iPod and is delighted to find that it's loaded with disco songs.
Ryan knows he's being tailed by the FBI, and feels safe enough to openly mock the poor bastards. "Sneakers, today, huh? Cool!"
Ryan is holding Giselle at gunpoint. She reveals she is The Fatalist and turns to run, not caring if he shoots her. Right as she turns around, Max is there to knock her out with a fist to the face.
Max: (Shaking off her bruised hand) Ahh! That hurt, but it felt so good!
Emma, a serial killer, complains to Joe, a cult leader, that Lily and her family are all crazy.
After spending a few episodes fawning over Emma and endearing himself to her, she and Mark are finally about to have an intimate moment. True to her nature, Emma tries to kiss him. Mark instantly recoils in shock and disgust. Though it quickly turns into a bit of a Tear Jerker, it's hilarious when Mark excitedly explains to her that "I have a mild case of haphephobia, and you need to read up on it if you want this to work" topping it off with a Cheshire Cat Grin. Understandably Emma responds by shoving his face back and calling him a nutjob, making him wig out a second time.
This exchange between Lily Grey and Joe:
Lily: Have you been writing?
Joe: ... I was in Arkansas.
Mike whacks Luke in the back of the head with a bat, then hits him in the side, then delivers a Flat "What." at Ryan's shocked expression.
"I am done with you and your international house of psychos."
Meanwhile, Emma is laughing her ass off.
Seeking shelter after the "International House of Psychos" failed to pan out, Joe, Emma, and Mandy end up with the Korban, a supposedly peaceful, "easily influenced" group that turns out to be a full-on, batshit-insane cult that engages in blood rituals.
In "The Messenger," Micah tells Joe about the cult's version of Heaven: "It's the ninth planet, just behind Neptune." Joe quietly reacts with a "This guy's cuckoo" face.
Just before heading out on a mission, Ryan hugs Max. She accuses him of getting soft. He tells her to shut up.
During a flashback in Season 1, Charlie visits Joe in prison to update him on what Claire's been doing.
Charlie: She went to a CÚline Dion concert on Friday, with her friend Lisa.
In the episode "Guilt," captured cultist Amanda Porter gives the good guys information about herself. Completely useless information, that is.
Debra: Uh, she's a Pisces. Favorite movie is The Notebook. She's an advocate for the death penalty. She believes in creationism over evolution, enjoys '70s soft rock, and hates peanut butter, whole milk, and Anne Hathaway.
A subtle and perhaps unintentional example: in "Fly Away," both Ryan and Joe (in separate scenes) make similar remarks about Lily.
Ryan: Don't be so melodramatic.
Joe: Y'know, she's a bit of a drama queen.
During their Enemy Mine situation, Joe asks Ryan if he should be wearing a disguise. Ryan responds by punching him in the face hard enough to bloody his nose, then hands him a towel big enough to cover his face.