Barrymore: Did you want the camera? Well we'll get one for you, stuff her!
From the very first episode, the question taker for the yellow couple complains about the questions being given, saying they're not 'intelligent' enough.
Moments later when they do move, on the first screen they get £150, and Barbara (the question taker) says if they go on, they bet they'll hit a Hot Spot. Sure enough, Robert (the one going across) hits the second screen and gets a Hot Spot.
Barrymore: *after collapsing in despair* I'm NOT going back over there!
On their next round, Barbara is given a question on sport, and demands that it's changed.
Barrymore: We'll change it to sorapt, which is sport backwards!
When it comes to them again, they hit a screen and win a lawnmower and gardening tools (Barbara: We haven't got a lawn, no!), and decide to move onto the next screen.
The blue couple gets asked a question, to which Barbara blurts out the answer (At the same time the blue contestant does, but it's hilarious nonetheless).
Barrymore: Ain't it lovely, if you win a couple of thousand, just give it away!
Robert and Barbara manage to get into the end game, they opt to go for the £1000 (no more than four Hot Spots) option due to their luck with them.
Barbara: *When selecting the second screen* Bottom, and don't you dare!*BWEEOOP-BWEEOOP-BWEEOOP!!!*
One episode of the 87/88 season had a brilliant moment at the start of the game. As the players are makign their way to their respective start screens, the red contestant goes BEHIND the topmost set of monitors instead of the front of it. She quickly realizes her mistake and goes back around the right way, embarassed, but still catches it from Barrymore.
Barrymore: Where the hell where you going?! She went round the back! I tell you what, you can't see the prizes around the back, it's a television! *turns and goes back to the question takers* What a good start(!) We've a couple here who've come all the way from Malaysia, they know the right way to go!
YMMV a little, but any time one of the screens are pressed and it takes at least 2-3 seconds for the prize to be revealed (Usually met with a confused 'Hello?' or something to that effect from Barrymore) should raise a chuckle.
A contestant from the Strike It Rich run was a bit too literal minded - they actually struck the screen instead of the button below. Barrymore's reaction to that is priceless.
The 1991 Christmas Special (with members of the Royal Air Force, Royal Navy, and British Army that served in The Gulf War competing with their wives) had a few, including...
Barrrymore going through an Army drill with the son of the Army contestant (and the Army contestant ordering Barrymore around).