Miracle: Cathcphrase: "Babies are gifts from God! Drummers are creeps."
Stuart: Catchphrase: "I need a catchphrase" (especially funny because Stuart keeps dropping this line throughout the episode like an actual catchphrase)
Melody is a creationist christian with New Age beliefs, despite being the SCIENCE teacher. She got the job by stripping naked in front of the school board and claiming she "didnt come from no monkey".
Stuart Proszackian singing "Someone Sent You a Prison Clown" for Larry on "Miracles Are Real"
Stuart: Ohhhhhh, someone sent you a prison clown, someone traded or bartered you a prison clown!
The meth cooking show manatee gag on "Math Lab."
The drug dealer known as "Sweetie Pie" because of his incredibly girly and high pitched voice. He's still incredibly dangerous, but he sounds like a little girl.
At the end, Larry complains that despite all the talk about drugs, the episode didnt actually show any of the bad consequences of drugs, all the injuries and sickness were unrelated.
The Long List of the various medications Willard has to take just to stay alive. One of them "keeps his kidneys on the inside".
In another episode, Andrew says that Willard only has one working kidney. Willard specifies that it's "working AGAINST him".
One episode revolves around Larry desperately trying to get the kids fit enough to pass the state's physical fitness standard, not helped by the fact that Willard accidentally made heart disease cool, leading to massive weight gain all around. However, it turns out that the state standard he's supposed to pass is Floridas, and by their standards all the kids are well above average. One of them even manages to do a single push-up, which the enormously obese controller says is a 100% improvement from the previous year.
Andrew talking about having a crush on both Larry and Melody, and wishes that he could somehow combine them into an ideal partner.
Helen: It's tough being bisexual, isnt it?
Andrew: I'm not gonna test well...
When Melody is forced to go back to school to get the required P.E credit for a diploma, she and Larry end up in a relationship, which causes a huge "Teacher-Student Romance Scandal" (despite both of them being adults). While the plot is funny on it's own, what makes it REALLY funny is that the episode reveals that Willard was once known as the "Whoop-Di-Doo Kid", and had a relationship with his teacher back when he was in high school. While the scandal of the Whoop-Di-Doo Kid swept the nation and is still part of school history, no one knew it had actually been Willard.